(Q39634639)

English

PI3K p110 alpha and p110 beta have differential effects on Akt activation and protection against oxidative stress-induced apoptosis in myoblasts

scientific article published on 16 October 2009

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

PI3K p110 alpha and p110 beta have differential effects on Akt activation and protection against oxidative stress-induced apoptosis in myoblasts (English)

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

0 references

author name string

R W Matheny

1

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

M L Adamo

2

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

publication date

16 October 2009

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Cell Death & Differentiation

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

17

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

4

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

677-688

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Specific function of phosphoinositide 3-kinase beta in the control of DNA replication

1 reference

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14 September 2017

Should individual PI3 kinase isoforms be targeted in cancer?

1 reference

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14 September 2017

PI 3-kinase and cancer: changing accents

1 reference

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14 September 2017

Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development

1 reference

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14 September 2017

Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis

1 reference

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14 September 2017

The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma.

1 reference

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14 September 2017

Phosphoinositide 3-kinases as a common platform for multi-hormone signaling.

1 reference

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14 September 2017

Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers

1 reference

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14 September 2017

PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms

1 reference

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14 September 2017

IGF-1 protects intestinal epithelial cells from oxidative stress-induced apoptosis

1 reference

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14 September 2017

A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2839024

14 September 2017

Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation

1 reference

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14 September 2017

Regulation of apoptosis by insulin-like growth factor (IGF)-I.

1 reference

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14 September 2017

Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2839024

14 September 2017

PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2839024

14 September 2017

Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2839024

14 September 2017

High frequency of mutations of the PIK3CA gene in human cancers

1 reference

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14 September 2017

Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase

1 reference

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14 September 2017

Insulin-like growth factor-1 protects H9c2 cardiac myoblasts from oxidative stress-induced apoptosis via phosphatidylinositol 3-kinase and extracellular signal-regulated kinase pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2839024

14 September 2017

Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2839024

14 September 2017

Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2839024

14 September 2017

Coordinate control of muscle cell survival by distinct insulin-like growth factor activated signaling pathways

1 reference

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14 September 2017

Signaling by distinct classes of phosphoinositide 3-kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2839024

14 September 2017

Multiple signaling pathways of the insulin-like growth factor 1 receptor in protection from apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2839024

14 September 2017

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2839024

14 September 2017

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2839024

14 September 2017

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

1 reference

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14 September 2017

Insulin-like growth factors and their binding proteins: biological actions

1 reference

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

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14 September 2017

Distinct roles of class IA PI3K isoforms in primary and immortalised macrophages

1 reference

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14 September 2017

Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling.

1 reference

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14 September 2017

Synthesis and biological evaluation of 4-morpholino-2-phenylquinazolines and related derivatives as novel PI3 kinase p110alpha inhibitors

1 reference

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Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors

1 reference

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14 September 2017

Importance of poly(ADP-ribose) polymerase and its cleavage in apoptosis. Lesson from an uncleavable mutant

1 reference

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25 September 2017

Phosphorylation of insulin receptor substrate-1 on multiple serine residues, 612, 632, 662, and 731, modulates insulin action

1 reference

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25 September 2017

Insulin-like growth factor-I receptor internalization regulates signaling via the Shc/mitogen-activated protein kinase pathway, but not the insulin receptor substrate-1 pathway

1 reference

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17 June 2018

Oncogenic signaling of class I PI3K isoforms

1 reference

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21 August 2018

Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes

1 reference

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21 August 2018

Identifiers

10.1038/CDD.2009.150

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Dimensions Publication ID

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

ResearchGate publication ID

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