(Q39640407)

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The low frequency of clinical resistance to PDGFR inhibitors in myeloid neoplasms with abnormalities of PDGFRA might be related to the limited repertoire of possible PDGFRA kinase domain mutations in vitro

scientific article published on October 25, 2010

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Europe PubMed Central

PubMed publication ID

13 September 2017

The low frequency of clinical resistance to PDGFR inhibitors in myeloid neoplasms with abnormalities of PDGFRA might be related to the limited repertoire of possible PDGFRA kinase domain mutations in vitro (English)

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Europe PubMed Central

PubMed publication ID

13 September 2017

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R. A. Engh

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9 August 2024

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N. von Bubnoff

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9 August 2024

S. P. Gorantla

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9 August 2024

T. M. Oliveira

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9 August 2024

S. Thöne

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9 August 2024

E. Aberg

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9 August 2024

C. Peschel

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9 August 2024

J. Duyster

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9 August 2024

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25 October 2010

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13 September 2017

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https://www.nature.com/articles/onc2010476.pdf

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9 August 2024

https://www.nature.com/articles/onc2010476.pdf

Portable Document Format

1 reference

10.1038/ONC.2010.476

https://api.crossref.org/works/10.1038/ONC.2010.476

9 August 2024

https://www.nature.com/articles/onc2010476

1 reference

10.1038/ONC.2010.476

https://api.crossref.org/works/10.1038/ONC.2010.476

9 August 2024

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

30

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Europe PubMed Central

PubMed publication ID

13 September 2017

8

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Europe PubMed Central

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13 September 2017

933-943

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

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Selecting optimal second-line tyrosine kinase inhibitor therapy for chronic myeloid leukemia patients after imatinib failure: does the BCR-ABL mutation status really matter?

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PKC412 overcomes resistance to imatinib in a murine model of FIP1L1-PDGFRα-induced myeloproliferative disease.

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PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib

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Activity of dasatinib, a dual SRC/ABL kinase inhibitor, and IPI-504, a heat shock protein 90 inhibitor, against gastrointestinal stromal tumor-associated PDGFRAD842V mutation.

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Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

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Clinical resistance to the kinase inhibitor PKC412 in acute myeloid leukemia by mutation of Asn-676 in the FLT3 tyrosine kinase domain

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Molecular correlates of imatinib resistance in gastrointestinal stromal tumors.

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Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumors.

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Impact of baseline BCR-ABL mutations on response to nilotinib in patients with chronic myeloid leukemia in chronic phase

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Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL

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Identification of a novel activating mutation (Y842C) within the activation loop of FLT3 in patients with acute myeloid leukemia (AML).

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Response and resistance in 300 patients with BCR-ABL-positive leukemias treated with imatinib in a single center: a 4.5-year follow-up

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Sorafenib is a potent inhibitor of FIP1L1-PDGFRalpha and the imatinib-resistant FIP1L1-PDGFRalpha T674I mutant

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FIP1L1-PDGFRalpha D842V, a novel panresistant mutant, emerging after treatment of FIP1L1-PDGFRalpha T674I eosinophilic leukemia with single agent sorafenib

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The c-KIT mutation causing human mastocytosis is resistant to STI571 and other KIT kinase inhibitors; kinases with enzymatic site mutations show different inhibitor sensitivity profiles than wild-type kinases and those with regulatory-type mutations

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Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder

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Pharmacokinetics and pharmacodynamics of imatinib in a phase I trial with chronic myeloid leukemia patients

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Activity of bosutinib, dasatinib, and nilotinib against 18 imatinib-resistant BCR/ABL mutants

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Detection and molecular monitoring of FIP1L1-PDGFRA-positive disease by analysis of patient-specific genomic DNA fusion junctions

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Primary resistance to imatinib in Fip1-like 1-platelet-derived growth factor receptor alpha-positive eosinophilic leukemia

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The small molecule tyrosine kinase inhibitor AMN107 inhibits TEL-PDGFRbeta and FIP1L1-PDGFRalpha in vitro and in vivo

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Phase I clinical and pharmacokinetic study of the Novel Raf kinase and vascular endothelial growth factor receptor inhibitor BAY 43-9006 in patients with advanced refractory solid tumors.

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FMS-like tyrosine kinase 3-internal tandem duplication tyrosine kinase inhibitors display a nonoverlapping profile of resistance mutations in vitro

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10.1038/ONC.2010.476

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

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