(Q39652655)

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14 February 2020

title

Low nociceptor GRK2 prolongs prostaglandin E2 hyperalgesia via biased cAMP signaling to Epac/Rap1, protein kinase Cepsilon, and MEK/ERK (English)

1 reference

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14 February 2020

1 reference

1 reference

1

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14 February 2020

Robert Dantzer

7

1 reference

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14 February 2020

Keith W. Kelley

8

1 reference

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14 February 2020

author name string

Huijing Wang

2

1 reference

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14 February 2020

Anibal Garza-Carbajal

3

1 reference

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14 February 2020

Hanneke L D M Willemen

4

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14 February 2020

Fried J Zwartkruis

5

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14 February 2020

John N Wood

6

1 reference

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14 February 2020

Cobi J Heijnen

9

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14 February 2020

Annemieke Kavelaars

10

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14 February 2020

language of work or name

English

0 references

publication date

1 September 2010

1 reference

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14 February 2020

published in

Journal of Neuroscience

1 reference

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14 February 2020

volume

30

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14 February 2020

issue

38

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14 February 2020

page(s)

12806-12815

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describes a project that uses

14 February 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6633564/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Role of protein kinase A in the maintenance of inflammatory pain

1 reference

12 December 2020

Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus

1 reference

12 December 2020

Decreased expression and activity of G-protein-coupled receptor kinases in peripheral blood mononuclear cells of patients with rheumatoid arthritis

1 reference

12 December 2020

Pharmacological modulation of secondary mediator systems--cyclic AMP and cyclic GMP--on inflammatory hyperalgesia

1 reference

12 December 2020

Agonist-induced phosphorylation by G protein-coupled receptor kinases of the EP4 receptor carboxyl-terminal domain in an EP3/EP4 prostaglandin E(2) receptor hybrid.

1 reference

12 December 2020

Specific Involvement of PKC-ε in Sensitization of the Neuronal Response to Painful Heat

1 reference

12 December 2020

Chronic hypersensitivity for inflammatory nociceptor sensitization mediated by the epsilon isozyme of protein kinase C.

1 reference

12 December 2020

Synucleins are a novel class of substrates for G protein-coupled receptor kinases

1 reference

12 December 2020

Prostaglandin receptor subtypes, EP3C and EP4, mediate the prostaglandin E2-induced cAMP production and sensitization of sensory neurons

1 reference

12 December 2020

Characterization of EP receptor subtypes responsible for prostaglandin E2-induced pain responses by use of EP1 and EP3 receptor knockout mice

1 reference

12 December 2020

Temporally regulated and tissue-specific gene manipulations in the adult and embryonic heart using a tamoxifen-inducible Cre protein

1 reference

12 December 2020

Sex hormones regulate the contribution of PKCepsilon and PKA signalling in inflammatory pain in the rat.

1 reference

12 December 2020

A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK.

1 reference

12 December 2020

NGF signaling in sensory neurons: evidence that early endosomes carry NGF retrograde signals

1 reference

12 December 2020

Direct modulation of synaptic vesicle priming by GABA(B) receptor activation at a glutamatergic synapse

1 reference

12 December 2020

Role of the sensory neuron cytoskeleton in second messenger signaling for inflammatory pain

1 reference

12 December 2020

Coupling of neuronal 5‐HT7 receptors to activation of extracellular‐regulated kinase through a protein kinase A‐independent pathway that can utilize Epac

1 reference

12 December 2020

Reduced GRK2 level in T cells potentiates chemotaxis and signaling in response to CCL4

1 reference

12 December 2020

Integrin signaling in inflammatory and neuropathic pain in the rat.

1 reference

12 December 2020

Rap1 regulates E-cadherin-mediated cell-cell adhesion

1 reference

12 December 2020

Nociceptor-specific gene deletion using heterozygous NaV1.8-Cre recombinase mice.

1 reference

12 December 2020

cAMP acts on exchange protein activated by cAMP/cAMP-regulated guanine nucleotide exchange protein to regulate transmitter release at the crayfish neuromuscular junction.

1 reference

12 December 2020

G protein-coupled receptor kinase 2 in multiple sclerosis and experimental autoimmune encephalomyelitis

1 reference

12 December 2020

Sensitization of TRPV1 by EP1 and IP reveals peripheral nociceptive mechanism of prostaglandins

1 reference

12 December 2020

G protein-coupled receptor kinase 2-mediated phosphorylation of ezrin is required for G protein-coupled receptor-dependent reorganization of the actin cytoskeleton

1 reference

12 December 2020

Epac mediates a cAMP-to-PKC signaling in inflammatory pain: an isolectin B4(+) neuron-specific mechanism.

1 reference

12 December 2020

G protein-coupled receptor kinase 2 negatively regulates chemokine signaling at a level downstream from G protein subunits

1 reference

12 December 2020

Interleukin-1alphabeta gene-deficient mice show reduced nociceptive sensitivity in models of inflammatory and neuropathic pain but not post-operative pain.

1 reference

12 December 2020

GRKs and beta-arrestins: roles in receptor silencing, trafficking and signaling

1 reference

12 December 2020

GRKs and arrestins: regulators of migration and inflammation

1 reference

12 December 2020

Prostaglandin E2 receptor EP4 contributes to inflammatory pain hypersensitivity.

1 reference

12 December 2020

Cardiac-specific ablation of G-protein receptor kinase 2 redefines its roles in heart development and beta-adrenergic signaling.

1 reference

12 December 2020

Epac proteins: multi-purpose cAMP targets

1 reference

12 December 2020

The G protein-coupled receptor kinase (GRK) interactome: role of GRKs in GPCR regulation and signaling

1 reference

12 December 2020

G protein-coupled receptor kinase 6 controls chronicity and severity of dextran sodium sulphate-induced colitis in mice.

1 reference

12 December 2020

Exchange protein activated by cAMP (Epac) mediates cAMP activation of p38 MAPK and modulation of Ca2+-dependent K+ channels in cerebellar neurons

1 reference

12 December 2020

A role for G protein-coupled receptor kinase 2 in mechanical allodynia

1 reference

12 December 2020

A critical role of the cAMP sensor Epac in switching protein kinase signalling in prostaglandin E2-induced potentiation of P2X3 receptor currents in inflamed rats

1 reference

12 December 2020

IL-1 beta signaling is required for mechanical allodynia induced by nerve injury and for the ensuing reduction in spinal cord neuronal GRK2

1 reference

12 December 2020

Rap1 is involved in the signal transduction of myelin-associated glycoprotein

1 reference

12 December 2020

Activation of exchange protein activated by cyclic-AMP enhances long-lasting synaptic potentiation in the hippocampus

1 reference

12 December 2020

The Cell and Molecular Basis of Mechanical, Cold, and Inflammatory Pain

1 reference

12 December 2020

Application of an Epac activator enhances neurotransmitter release at excitatory central synapses.

1 reference

12 December 2020

Endogenous Gs-coupled receptors in smooth muscle exhibit differential susceptibility to GRK2/3-mediated desensitization

1 reference

12 December 2020

Epac and phospholipase Cepsilon regulate Ca2+ release in the heart by activation of protein kinase Cepsilon and calcium-calmodulin kinase II.

1 reference

12 December 2020

Protein kinase C epsilon contributes to basal and sensitizing responses of TRPV1 to capsaicin in rat dorsal root ganglion neurons

1 reference

12 December 2020

Activation of Gi induces mechanical hyperalgesia poststress or inflammation

1 reference

12 December 2020

PKCepsilon-dependent potentiation of TTX-resistant Nav1.8 current by neurokinin-1 receptor activation in rat dorsal root ganglion neurons

1 reference

12 December 2020

Critical role of nociceptor plasticity in chronic pain

1 reference

12 December 2020

GRK2: a novel cell-specific regulator of severity and duration of inflammatory pain

1 reference

12 December 2020

Microglial/macrophage GRK2 determines duration of peripheral IL-1beta-induced hyperalgesia: contribution of spinal cord CX3CR1, p38 and IL-1 signaling.

1 reference

12 December 2020

A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia

1 reference

12 December 2020

International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes

1 reference

12 December 2020

In situ hybridization studies of prostacyclin receptor mRNA expression in various mouse organs

1 reference

12 December 2020

Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function

1 reference

12 December 2020

Rapid Ca2+-mediated activation of Rap1 in human platelets

1 reference

12 December 2020

The G protein-coupled receptor kinase 2 is a microtubule-associated protein kinase that phosphorylates tubulin

1 reference

12 December 2020

Molecular mechanisms of G protein-coupled receptor signaling: role of G protein-coupled receptor kinases and arrestins in receptor desensitization and resensitization

1 reference

12 December 2020

GTP-binding-protein-coupled receptor kinase 2 (GRK2) binds and phosphorylates tubulin.

1 reference

12 December 2020

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

1 reference

12 December 2020

10.1523/JNEUROSCI.3142-10.2010

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20861385%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

1 reference

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14 February 2020

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