(Q39653657)

English

Emodin triggers DNA double-strand breaks by stabilizing topoisomerase II-DNA cleavage complexes and by inhibiting ATP hydrolysis of topoisomerase II.

scientific article published on 20 September 2010

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14 February 2020

Emodin triggers DNA double-strand breaks by stabilizing topoisomerase II-DNA cleavage complexes and by inhibiting ATP hydrolysis of topoisomerase II (English)

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14 February 2020

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ChEBI release 2020-05-28

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14 February 2020

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Yan Li

1

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14 February 2020

Yang Luan

2

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14 February 2020

Xinming Qi

3

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14 February 2020

Ming Li

4

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14 February 2020

Likun Gong

5

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14 February 2020

Xiongfei Wu

7

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14 February 2020

Yuanfeng Wu

8

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14 February 2020

Min Chen

9

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14 February 2020

Guozhen Xing

10

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14 February 2020

Jun Yao

11

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14 February 2020

Jin Ren

12

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14 February 2020

publication date

20 September 2010

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14 February 2020

Toxicological Sciences

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14 February 2020

118

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14 February 2020

2

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14 February 2020

435-443

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14 February 2020

Novel indenoisoquinolines NSC 725776 and NSC 724998 produce persistent topoisomerase I cleavage complexes and overcome multidrug resistance

1 reference

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21 January 2018

A pathway for generation and processing of double-strand breaks during meiotic recombination in S. cerevisiae

1 reference

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1 reference

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1 reference

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21 January 2018

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21 January 2018

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21 January 2018

Mitoxantrone resistance in HL-60 leukemia cells: reduced nuclear topoisomerase II catalytic activity and drug-induced DNA cleavage in association with reduced expression of the topoisomerase II beta isoform

1 reference

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21 January 2018

Salvicine functions as novel topoisomerase II poison by binding to ATP pocket

1 reference

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21 January 2018

Topoisomerase II poisoning by ICRF-193.

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21 January 2018

Mutagenicity of substituted anthraquinones in the Ames/Salmonella microsome system

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21 January 2018

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21 January 2018

Characterization of the genotoxicity of anthraquinones in mammalian cells

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21 January 2018

Retrospective study on laxative use and melanosis coli as risk factors for colorectal neoplasma.

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21 January 2018

DNA damage and repair in individual cells: applications of the comet assay in radiobiology

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21 January 2018

Enhancement of chemotherapy by manipulation of tumour pH.

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21 January 2018

The repair of double-strand breaks in DNA; a model involving recombination

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21 January 2018

Antitumor bisdioxopiperazines inhibit yeast DNA topoisomerase II by trapping the enzyme in the form of a closed protein clamp

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21 January 2018

A simple technique for quantitation of low levels of DNA damage in individual cells

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21 January 2018

Assessment of DNA double-strand breaks and gammaH2AX induced by the topoisomerase II poisons etoposide and mitoxantrone

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21 January 2018

The foci of DNA double strand break-recognition proteins localize with gammaH2AX after heat treatment

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21 January 2018

Mutagenicity of anthraquinones in the Salmonella preincubation test

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21 January 2018

The Relationship between Cellular Radiosensitivity and Radiation-Induced DNA Damage Measured by the Comet Assay

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21 January 2018

Nucleotide-dependent domain movement in the ATPase domain of a human type IIA DNA topoisomerase.

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21 January 2018

Genotoxicity of naturally occurring hydroxyanthraquinones.

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21 January 2018

Stabilization of eukaryotic topoisomerase II-DNA cleavage complexes

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21 January 2018

Metabolic activation of herbal and dietary constituents and its clinical and toxicological implications: an update

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21 January 2018

Olaquindox-induced genotoxicity and oxidative DNA damage in human hepatoma G2 (HepG2) cells.

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21 January 2018

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