(Q39654314)

English

Intranasal immunization with pneumococcal conjugate vaccines with LT-K63, a nontoxic mutant of heat-Labile enterotoxin, as adjuvant rapidly induces protective immunity against lethal pneumococcal infections in neonatal mice

scientific article published on March 2002

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Intranasal immunization with pneumococcal conjugate vaccines with LT-K63, a nontoxic mutant of heat-Labile enterotoxin, as adjuvant rapidly induces protective immunity against lethal pneumococcal infections in neonatal mice (English)

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

0 references

Ingileif Jonsdottir

6

object named as

Ingileif Jonsdottir

0 references

Claire-Anne Siegrist

5

object named as

Claire-Anne Siegrist

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

author name string

Håvard Jakobsen

1

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Stefania Bjarnarson

2

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Giuseppe Del Giudice

3

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Monique Moreau

4

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Ingileif Jonsdottir

6

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

language of work or name

0 references

publication date

1 March 2002

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Infection and Immunity

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

70

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

3

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

1443-1452

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Neonatal and early life vaccinology

1 reference

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Mucosal delivery of inactivated influenza vaccine induces B-cell-dependent heterosubtypic cross-protection against lethal influenza A H5N1 virus infection

1 reference

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14 September 2017

Mucosal vaccines: non toxic derivatives of LT and CT as mucosal adjuvants.

1 reference

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14 September 2017

Prevalence of nasopharyngeal antibiotic-resistant pneumococcal carriage in children attending private paediatric practices in Johannesburg

1 reference

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14 September 2017

Intranasal immunization with SAG1 and nontoxic mutant heat-labile enterotoxins protects mice against Toxoplasma gondii

1 reference

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14 September 2017

Efficacy of a pneumococcal conjugate vaccine against acute otitis media

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127807

14 September 2017

LTK63 and LTR72, two mucosal adjuvants ready for clinical trials

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127807

14 September 2017

Absence of marginal zone B cells in Pyk-2-deficient mice defines their role in the humoral response

1 reference

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14 September 2017

Efficacy of pneumococcal conjugate vaccines in large scale field trials

1 reference

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14 September 2017

Immunogenicity of pneumococcal conjugate vaccines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127807

14 September 2017

Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children. Northern California Kaiser Permanente Vaccine Study Center Group

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127807

14 September 2017

Mutants of Escherichia coli heat-labile toxin act as effective mucosal adjuvants for nasal delivery of an acellular pertussis vaccine: differential effects of the nontoxic AB complex and enzyme activity on Th1 and Th2 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127807

14 September 2017

A new rat model of otitis media caused by Streptococcus pneumoniae: conditions and application in immunization protocols

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127807

14 September 2017

Intranasal immunization with pneumococcal polysaccharide conjugate vaccines with nontoxic mutants of Escherichia coli heat-labile enterotoxins as adjuvants protects mice against invasive pneumococcal infections.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127807

14 September 2017

Genetically derived toxoids for use as vaccines and adjuvants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127807

14 September 2017

Safety and immunogenicity of heptavalent pneumococcal CRM197 conjugate vaccine in infants and toddlers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127807

14 September 2017

Intranasal immunization with pneumococcal polysaccharide conjugate vaccines protects mice against invasive pneumococcal infections

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127807

14 September 2017

Protective immunity of microsphere-based mucosal vaccines against lethal intranasal challenge with Streptococcus pneumoniae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127807

14 September 2017

Immune modulation by the cholera-like enterotoxins: from adjuvant to therapeutic

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127807

14 September 2017

Isotypes and opsonophagocytosis of pneumococcus type 6B antibodies elicited in infants and adults by an experimental pneumococcus type 6B-tetanus toxoid vaccine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127807

14 September 2017

DNA immunization circumvents deficient induction of T helper type 1 and cytotoxic T lymphocyte responses in neonates and during early life

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127807

14 September 2017

Induction of antigen-specific antibodies in vaginal secretions by using a nontoxic mutant of heat-labile enterotoxin as a mucosal adjuvant

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127807

14 September 2017

Pneumococcal polysaccharide vaccine efficacy. An evaluation of current recommendations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127807

14 September 2017

Pneumococcal disease: prospects for a new generation of vaccines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127807

14 September 2017

Laboratory and preliminary clinical characterization of Vi capsular polysaccharide-protein conjugate vaccines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127807

14 September 2017

Mutants of Escherichia coli heat-labile toxin lacking ADP-ribosyltransferase activity act as nontoxic, mucosal adjuvants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127807

14 September 2017

T cell-independent antigens type 2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127807

14 September 2017

Polysaccharide-protein conjugates: a new generation of vaccines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127807

14 September 2017

Antimicrobial Resistance in Streptococcus pneumoniae: An Overview

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127807

14 September 2017

Thymus-independent and thymus-dependent responses to polysaccharide antigens

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127807

14 September 2017

https://pubmed.ncbi.nlm.nih.gov/11854231

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Subclass restriction of murine anti-carbohydrate antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127807

14 September 2017

Genetic detoxification of bacterial toxins: a new approach to vaccine development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127807

14 September 2017

The epidemiology of pneumococcal disease in infants and children.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127807

14 September 2017

Preventing pneumococcal disease in children: recommendations for using pneumococcal vaccine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127807

14 September 2017

Immunogenicity of Streptococcus pneumoniae type 6B and 14 polysaccharide-tetanus toxoid conjugates and the effect of uncoupled polysaccharide on the antigen-specific immune response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127807

25 September 2017

Mucosal adjuvanticity and immunogenicity of LTR72, a novel mutant of Escherichia coli heat-labile enterotoxin with partial knockout of ADP-ribosyltransferase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127807

15 June 2018

Safety and immunogenicity of tetravalent pneumococcal vaccines containing 6B, 14, 19F and 23F polysaccharides conjugated to either tetanus toxoid or diphtheria toxoid in young infants and their boosterability by native polysaccharide antigens.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127807

15 June 2018

Comparative in vivo analysis of IgA- and IgG-mediated mucosal defense against bacterial pathogens.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127807

15 June 2018

Modulation of B-cell activation by the B subunit of Escherichia coli enterotoxin: receptor interaction up-regulates MHC class II, B7, CD40, CD25 and ICAM-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127807

15 June 2018

Prevalence of serotypes and molecular epidemiology of Streptococcus pneumoniae strains isolated from children in Beijing, China: identification of two novel multiply-resistant clones

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127807

21 August 2018

Deficient IL-12(p35) gene expression by dendritic cells derived from neonatal monocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127807

21 August 2018

Protective efficacy against respiratory syncytial virus following murine neonatal immunization with BBG2Na vaccine: influence of adjuvants and maternal antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127807

21 August 2018

Protection against Helicobacter pylori infection in mice by intragastric vaccination with H. pylori antigens is achieved using a non-toxic mutant of E. coli heat-labile enterotoxin (LT) as adjuvant.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127807

21 August 2018

Drug-resistant Streptococcus pneumoniae.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127807

21 August 2018

Streptococcus pneumoniae capsular polysaccharide-diphtheria toxoid conjugate vaccine is immunogenic in early infancy and able to induce immunologic memory.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127807

21 August 2018

A glycoprotein pneumococcal conjugate vaccine primes for antibody responses to a pneumococcal polysaccharide vaccine in Gambian children

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127807

21 August 2018

Neonatal and early life immune responses to various forms of vaccine antigens qualitatively differ from adult responses: predominance of a Th2-biased pattern which persists after adult boosting.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127807

21 August 2018

Immunogenicity and efficacy of Streptococcus pneumoniae polysaccharide-protein conjugate vaccines against homologous and heterologous serotypes in the chinchilla otitis media model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127807

21 August 2018

The protective efficacy of polyvalent pneumococcal polysaccharide vaccine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127807

21 August 2018

Opsonization and antibodies to capsular and cell wall polysaccharides of Streptococcus pneumoniae

1 reference

https://pubmed.ncbi.nlm.nih.gov/11854231

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathogenesis of Pneumococcal Infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/11854231

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of neonatal TH1 and CTL responses by live viral vaccines: a role for replication patterns within antigen presenting cells?

1 reference

https://pubmed.ncbi.nlm.nih.gov/11854231

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human marginal-zone B cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11854231

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enterotoxin adjuvants have direct effects on T cells and antigen-presenting cells that result in either interleukin-4-dependent or -independent immune responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/11854231

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pneumococcal pneumonia and bacteremia model in mice for the analysis of protective antibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/11854231

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The ability of B cells and dendritic cells to present antigen increases during ontogeny

1 reference

https://pubmed.ncbi.nlm.nih.gov/11854231

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Delayed and deficient establishment of the long-term bone marrow plasma cell pool during early life

1 reference

https://pubmed.ncbi.nlm.nih.gov/11854231

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the antibody response to pneumococcal glycoconjugates and the effect of heat-labile enterotoxin on IGg subclasses after intranasal immunization

1 reference

https://pubmed.ncbi.nlm.nih.gov/11854231

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

What are the limits of adjuvanticity?

1 reference

https://pubmed.ncbi.nlm.nih.gov/11854231

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Avidity and subclasses of IgG after immunization of infants with an 11-valent pneumococcal conjugate vaccine with or without aluminum adjuvant

1 reference

https://pubmed.ncbi.nlm.nih.gov/11854231

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antibody response to pneumococcal vaccination in children younger than five years of age

1 reference

https://pubmed.ncbi.nlm.nih.gov/11854231

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IgG2 subclass restriction of antibody to pneumococcal polysaccharides

1 reference

https://pubmed.ncbi.nlm.nih.gov/11854231

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Natural and vaccine-related immunity to Streptococcus pneumoniae

1 reference

https://pubmed.ncbi.nlm.nih.gov/11854231

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IgG subclasses in bacterial infections

1 reference

https://pubmed.ncbi.nlm.nih.gov/11854231

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pneumococcal capsular polysaccharide-meningococcal outer membrane protein complex conjugate vaccines: immunogenicity and efficacy in experimental pneumococcal otitis media

1 reference

https://pubmed.ncbi.nlm.nih.gov/11854231

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression and functional characteristics of the complement receptor type 2 on adult and neonatal B lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/11854231

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carriage of pneumococci after pneumococcal vaccination

1 reference

https://pubmed.ncbi.nlm.nih.gov/11854231

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pentavalent pneumococcal oligosaccharide conjugate vaccine PncCRM is well-tolerated and able to induce an antibody response in infants

1 reference

https://pubmed.ncbi.nlm.nih.gov/11854231

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduction of nasopharyngeal carriage of pneumococci during the second year of life by a heptavalent conjugate pneumococcal vaccine

1 reference

https://pubmed.ncbi.nlm.nih.gov/11854231

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PNEUMOCOCCAL BACTEREMIA WITH ESPECIAL REFERENCE TO BACTEREMIC PNEUMOCOCCAL PNEUMONIA

1 reference

https://pubmed.ncbi.nlm.nih.gov/11854231

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immune responses of infants vaccinated with serotype 6B pneumococcal polysaccharide conjugated with tetanus toxoid

1 reference

https://pubmed.ncbi.nlm.nih.gov/11854231

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/IAI.70.3.1443-1452.2002

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

ResearchGate publication ID

0 references

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