(Q39655474)

English

Genetic downregulation of AMPK-alpha isoforms uncovers the mechanism by which metformin decreases FA uptake and oxidation in skeletal muscle cells

scientific article published on 15 September 2010

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scholarly article

1 reference

Europe PubMed Central

13 September 2017

Genetic downregulation of AMPK-alpha isoforms uncovers the mechanism by which metformin decreases FA uptake and oxidation in skeletal muscle cells (English)

1 reference

Europe PubMed Central

13 September 2017

1 reference

based on heuristic

inferred from title

skeletal muscle cell

1 reference

based on heuristic

inferred from title

author name string

Lindsey D Bogachus

1

1 reference

Europe PubMed Central

13 September 2017

Lorraine P Turcotte

2

1 reference

Europe PubMed Central

13 September 2017

publication date

15 September 2010

1 reference

Europe PubMed Central

13 September 2017

American Journal of Physiology - Cell Physiology

1 reference

Europe PubMed Central

13 September 2017

299

1 reference

Europe PubMed Central

13 September 2017

6

1 reference

Europe PubMed Central

13 September 2017

C1549-61

1 reference

Europe PubMed Central

13 September 2017

CaMKK is an upstream signal of AMP-activated protein kinase in regulation of substrate metabolism in contracting skeletal muscle

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

Metformin restores responses to insulin but not to growth hormone in Sprague-Dawley rats

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

Thiazolidinediones, like metformin, inhibit respiratory complex I: a common mechanism contributing to their antidiabetic actions?

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

Fuel economy in food-deprived skeletal muscle: signaling pathways and regulatory mechanisms.

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

Regulation of AMP-activated protein kinase and acetyl-CoA carboxylase phosphorylation by palmitate in skeletal muscle cells

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways.

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex.

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

Membrane fatty acid transporters as regulators of lipid metabolism: implications for metabolic disease

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

Regulation of fatty acid uptake into tissues: lipoprotein lipase- and CD36-mediated pathways

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

The deacetylase enzyme SIRT1 is not associated with oxidative capacity in rat heart and skeletal muscle and its overexpression reduces mitochondrial biogenesis

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

Insulin-independent pathways mediating glucose uptake in hindlimb-suspended skeletal muscle

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

Compensatory increases in nuclear PGC1alpha protein are primarily associated with subsarcolemmal mitochondrial adaptations in ZDF rats

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

Insulin-stimulated phosphorylation of the Akt substrate AS160 is impaired in skeletal muscle of type 2 diabetic subjects

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

Short-term AMP-regulated protein kinase activation enhances insulin-sensitive fatty acid uptake and increases the effects of insulin on fatty acid oxidation in L6 muscle cells

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

Phosphatidylinositol 3-kinase-dependent insulin regulation of long-chain fatty acid (LCFA) metabolism in L6 muscle cells: involvement of atypical protein kinase C-zeta in LCFA uptake but not oxidation

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

The many ways to regulate glucose transporter 4.

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

Metformin enhances insulin signalling in insulin-dependent and-independent pathways in insulin resistant muscle cells

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

Restoration of impaired p38 activation by insulin in insulin resistant skeletal muscle cells treated with thiazolidinediones

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

Cellular fatty acid transport in heart and skeletal muscle as facilitated by proteins

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

Metformin improves atypical protein kinase C activation by insulin and phosphatidylinositol-3,4,5-(PO4)3 in muscle of diabetic subjects

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

AMP-activated protein kinase activity and glucose uptake in rat skeletal muscle

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

Metformin Increases AMP-Activated Protein Kinase Activity in Skeletal Muscle of Subjects With Type 2 Diabetes

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

Metformin suppresses glucose-6-phosphatase expression by a complex I inhibition and AMPK activation-independent mechanism

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

Prolonged exposure to palmitate impairs fatty acid oxidation despite activation of AMP-activated protein kinase in skeletal muscle cells.

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

AMPK activation is not critical in the regulation of muscle FA uptake and oxidation during low-intensity muscle contraction

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

Regulation of fatty acid oxidation in skeletal muscle

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

Sirt1 increases skeletal muscle precursor cell proliferation

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

Metabolic adaptations through the PGC-1 alpha and SIRT1 pathways

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

AMPK and SIRT1: a long-standing partnership?

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

Metabolic actions of metformin in the heart can occur by AMPK-independent mechanisms

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

AICAR and metformin, but not exercise, increase muscle glucose transport through AMPK-, ERK-, and PDK1-dependent activation of atypical PKC.

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha2 isoform.

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

Insulin signalling and the regulation of glucose and lipid metabolism

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

Conserved metabolic regulatory functions of sirtuins

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

AMP kinase activation with AICAR simultaneously increases fatty acid and glucose oxidation in resting rat soleus muscle

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

Metformin and exercise reduce muscle FAT/CD36 and lipid accumulation and blunt the progression of high-fat diet-induced hyperglycemia

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

ERK1/2 inhibition prevents contraction-induced increase in plasma membrane FAT/CD36 content and FA uptake in rodent muscle

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

Dissociation of AMPK activity and ACCbeta phosphorylation in human muscle during prolonged exercise

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells.

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

Role of AMP-activated protein kinase in mechanism of metformin action

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo. Role of mitochondrial reactive nitrogen species

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

Caffeine-induced Ca2+ release increases AMPK-dependent glucose uptake in rodent soleus muscle

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

Effects of non-esterified fatty acids on insulin-stimulated glucose transport in isolated skeletal muscle from patients with type 2 (non-insulin-dependent) diabetes mellitus

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00279.2010

21 January 2018

Identifiers

10.1152/AJPCELL.00279.2010

1 reference

Europe PubMed Central

13 September 2017

1 reference

Europe PubMed Central

13 September 2017

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