(Q39659765)

English

A single mutation at Tyr143 of human S-adenosylhomocysteine hydrolase renders the enzyme thermosensitive and affects the oxidation state of bound cofactor nicotinamide-adenine dinucleotide.

scientific article published on December 2006

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16872278%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

A single mutation at Tyr143 of human S-adenosylhomocysteine hydrolase renders the enzyme thermosensitive and affects the oxidation state of bound cofactor nicotinamide-adenine dinucleotide (English)

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27 December 2019

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27 December 2019

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S Harvey Mudd

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27 December 2019

author name string

Robert Beluzić

1

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27 December 2019

Mario Cuk

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27 December 2019

Tea Pavkov

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27 December 2019

Ksenija Fumić

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27 December 2019

Ivo Barić

5

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27 December 2019

Oliver Vugrek

8

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27 December 2019

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publication date

1 December 2006

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27 December 2019

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9

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Biochemical Journal

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27 December 2019

400

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27 December 2019

2

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27 December 2019

245-253

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27 December 2019

S-adenosylhomocysteine hydrolase deficiency in a 26-year-old man.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1652816

14 September 2017

S-Adenosylhomocysteine hydrolase deficiency: a second patient, the younger brother of the index patient, and outcomes during therapy

1 reference

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14 September 2017

DICHROWEB, an online server for protein secondary structure analyses from circular dichroism spectroscopic data

1 reference

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14 September 2017

S-adenosylmethionine: nothing goes to waste

1 reference

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14 September 2017

S-adenosylhomocysteine hydrolase deficiency in a human: a genetic disorder of methionine metabolism

1 reference

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14 September 2017

The enzymatic synthesis of S-adenosyl-L-homocysteine from adenosine and homocysteine

1 reference

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14 September 2017

SWISS-MODEL: An automated protein homology-modeling server

1 reference

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14 September 2017

Catalytic strategy of S-adenosyl-L-homocysteine hydrolase: transition-state stabilization and the avoidance of abortive reactions

1 reference

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14 September 2017

Catalytic mechanism of S-adenosylhomocysteine hydrolase. Site-directed mutagenesis of Asp-130, Lys-185, Asp-189, and Asn-190

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1652816

14 September 2017

Plasma homocysteine as a risk factor for dementia and Alzheimer's disease

1 reference

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14 September 2017

Inhibition of S-adenosylhomocysteine hydrolase by acyclic sugar adenosine analogue D-eritadenine. Crystal structure of S-adenosylhomocysteine hydrolase complexed with D-eritadenine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1652816

14 September 2017

Effects of site-directed mutagenesis on structure and function of recombinant rat liver S-adenosylhomocysteine hydrolase. Crystal structure of D244E mutant enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1652816

14 September 2017

Crystal structure of S-adenosylhomocysteine hydrolase from rat liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1652816

14 September 2017

Structure determination of selenomethionyl S-adenosylhomocysteine hydrolase using data at a single wavelength

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1652816

14 September 2017

SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1652816

14 September 2017

The mouse lethal nonagouti (a(x)) mutation deletes the S-adenosylhomocysteine hydrolase (Ahcy) gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1652816

14 September 2017

A single mutation at lysine 426 of human placental S-adenosylhomocysteine hydrolase inactivates the enzyme.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1652816

14 September 2017

The occurrence of C-H...O hydrogen bonds in proteins

1 reference

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14 September 2017

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1652816

14 September 2017

Inactivation of S-adenosyl-L-homocysteine hydrolase by cAMP results from dissociation of enzyme-bound NAD+.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1652816

14 September 2017

Expression of rat liver S-adenosylhomocysteinase cDNA in Escherichia coli and mutagenesis at the putative NAD binding site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1652816

14 September 2017

Sequence of full length cDNA for human S-adenosylhomocysteine hydrolase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1652816

14 September 2017

Site-directed mutagenesis of rat liver S-adenosylhomocysteinase. Effect of conversion of aspartic acid 244 to glutamic acid on coenzyme binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1652816

14 September 2017

Biological Methylation: Selected Aspects

1 reference

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14 September 2017

Mechanism for enzymatic thioether formation. Mechanism of action of S-adenosylhomocysteinase

1 reference

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14 September 2017

The mechanism of action of S-adenosylhomocysteinase

1 reference

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14 September 2017

Homocysteine trials--clear outcomes for complex reasons

1 reference

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21 August 2018

Catalytic mechanism of S-adenosylhomocysteine hydrolase: roles of His 54, Asp130, Glu155, Lys185, and Aspl89.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1652816

21 August 2018

Site-directed mutagenesis using a single mutagenic oligonucleotide and DpnI digestion of template DNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1652816

21 August 2018

DICHROWEB: an interactive website for the analysis of protein secondary structure from circular dichroism spectra.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1652816

21 August 2018

The role of cysteine 78 in fluorosulfonylbenzoyladenosine inactivation of rat liver S-adenosylhomocysteine hydrolase.

1 reference

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21 August 2018

Substrate binding stabilizes S-adenosylhomocysteine hydrolase in a closed conformation

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

S-Adenosylhomocysteinase: mechanism of inactivation by 2'-deoxyadenosine and interaction with other nucleosides

1 reference

https://pubmed.ncbi.nlm.nih.gov/16872278

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of nicotinamide adenine dinucleotide in the inhibition of bovine liver S-adenosylhomocysteine hydrolase by neplanocin A

1 reference

https://pubmed.ncbi.nlm.nih.gov/16872278

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma homocysteine levels and mortality in patients with coronary artery disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16872278

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1042/BJ20060749

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16872278%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16872278%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16872278%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

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