(Q39664260)

13 September 2017

UBQLN2/P62 cellular recycling pathways in amyotrophic lateral sclerosis and frontotemporal dementia (English)

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amyotrophic lateral sclerosis and frontotemporal dementia

13 September 2017

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amyotrophic lateral sclerosis

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dementia

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frontotemporal dementia

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Faisal Fecto

1

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PubMed ID

22246868

13 September 2017

Teepu Siddique

series ordinal

2

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13 September 2017

1 February 2012

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13 September 2017

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13 September 2017

45

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13 September 2017

2

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13 September 2017

157-162

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Making connections: pathology and genetics link amyotrophic lateral sclerosis with frontotemporal lobe dementia.

13 September 2017

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Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

21 January 2018

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TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis

21 January 2018

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TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis

21 January 2018

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Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6

21 January 2018

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Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis

21 January 2018

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Mutations of optineurin in amyotrophic lateral sclerosis

21 January 2018

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Exome sequencing reveals VCP mutations as a cause of familial ALS

21 January 2018

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SQSTM1 mutations in familial and sporadic amyotrophic lateral sclerosis

21 January 2018

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Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia

21 January 2018

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Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS

21 January 2018

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A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD

21 January 2018

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Ubiquitin-binding protein p62 is present in neuronal and glial inclusions in human tauopathies and synucleinopathies

21 January 2018

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p62 Is a common component of cytoplasmic inclusions in protein aggregation diseases

21 January 2018

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Differential involvement of optineurin in amyotrophic lateral sclerosis with or without SOD1 mutations

21 January 2018

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Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease

21 January 2018

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Inclusion body myopathy, Paget's disease of the bone and fronto-temporal dementia: a disorder of autophagy

21 January 2018

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VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD

21 January 2018

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Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth

21 January 2018

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Genetics of Paget's disease of bone

21 January 2018

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Genome-wide association study identifies variants at CSF1, OPTN and TNFRSF11A as genetic risk factors for Paget's disease of bone

21 January 2018

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Valosin-containing protein disease: inclusion body myopathy with Paget's disease of the bone and fronto-temporal dementia

21 January 2018

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Ubiquilin interacts with ubiquitylated proteins and proteasome through its ubiquitin-associated and ubiquitin-like domains

21 January 2018

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Emerging role of Alzheimer's disease-associated ubiquilin-1 in protein aggregation

21 January 2018

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Potentiation of amyotrophic lateral sclerosis (ALS)-associated TDP-43 aggregation by the proteasome-targeting factor, ubiquilin 1.

21 January 2018

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Ubiquilin modifies TDP-43 toxicity in a Drosophila model of amyotrophic lateral sclerosis (ALS).

21 January 2018

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Degradation of TDP-43 and its pathogenic form by autophagy and the ubiquitin-proteasome system.

21 January 2018

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Regulation of TDP-43 aggregation by phosphorylation and p62/SQSTM1.

21 January 2018

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The role of the ubiquitin proteasome system in synapse remodeling and neurodegenerative diseases

21 January 2018

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Depletion of 26S proteasomes in mouse brain neurons causes neurodegeneration and Lewy-like inclusions resembling human pale bodies.

21 January 2018

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Functional alterations of the ubiquitin-proteasome system in motor neurons of a mouse model of familial amyotrophic lateral sclerosis

21 January 2018

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Formation of high molecular weight complexes of mutant Cu, Zn-superoxide dismutase in a mouse model for familial amyotrophic lateral sclerosis.

21 January 2018

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Proteasomal inhibition causes the formation of protein aggregates containing a wide range of proteins, including nitrated proteins

21 January 2018

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Aggregate formation in the spinal cord of mutant SOD1 transgenic mice is reversible and mediated by proteasomes

21 January 2018

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Proteasomal degradation of mutant superoxide dismutases linked to amyotrophic lateral sclerosis

21 January 2018

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Disease-associated prion protein oligomers inhibit the 26S proteasome

21 January 2018

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Neuronal dysfunction in a polyglutamine disease model occurs in the absence of ubiquitin-proteasome system impairment and inversely correlates with the degree of nuclear inclusion formation

21 January 2018

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Accumulation of ubiquitin conjugates in a polyglutamine disease model occurs without global ubiquitin/proteasome system impairment

21 January 2018

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Autophagosomes in GFP-LC3 Transgenic Mice.

21 January 2018

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Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

21 January 2018

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Loss of autophagy in the central nervous system causes neurodegeneration in mice

21 January 2018

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Autophagy and the ubiquitin-proteasome system: collaborators in neuroprotection

21 January 2018

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Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates.

21 January 2018

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Lithium delays progression of amyotrophic lateral sclerosis

21 January 2018

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Autophagy in neurodegeneration: two sides of the same coin

21 January 2018

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Sequestosome 1/p62 links familial ALS mutant SOD1 to LC3 via an ubiquitin-independent mechanism.

21 January 2018

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Motor deficit in a Drosophila model of mucolipidosis type IV due to defective clearance of apoptotic cells.

21 January 2018

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Motor neuron disease occurring in a mutant dynactin mouse model is characterized by defects in vesicular trafficking

21 January 2018

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Autophagy: from phenomenology to molecular understanding in less than a decade

21 January 2018

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PLIC proteins or ubiquilins regulate autophagy-dependent cell survival during nutrient starvation

21 January 2018

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Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy

21 January 2018

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Ubiquilin at a crossroads in protein degradation pathways

21 January 2018

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Physiological significance of selective degradation of p62 by autophagy

21 January 2018

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p62 positive, TDP-43 negative, neuronal cytoplasmic and intranuclear inclusions in the cerebellum and hippocampus define the pathology of C9orf72-linked FTLD and MND/ALS

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/MUS.23278

1 reference

13 September 2017

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PubMed ID

22246868