(Q41997710)

15 October 2017

Potentiation of amyotrophic lateral sclerosis (ALS)-associated TDP-43 aggregation by the proteasome-targeting factor, ubiquilin 1. (English)

1 reference

amyotrophic lateral sclerosis

15 October 2017

0 references

author name string

Sang Hwa Kim

1

1 reference

15 October 2017

Yuling Shi

2

1 reference

15 October 2017

Keith A Hanson

3

1 reference

15 October 2017

Leah M Williams

4

1 reference

15 October 2017

Ryo Sakasai

5

1 reference

15 October 2017

Michael J Bowler

6

1 reference

15 October 2017

Randal S Tibbetts

7

1 reference

15 October 2017

language of work or name

English

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publication date

26 December 2008

1 reference

Journal of Biological Chemistry

15 October 2017

1 reference

15 October 2017

284

1 reference

15 October 2017

12

1 reference

15 October 2017

8083-8092

1 reference

describes a project that uses

15 October 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2658102/fullTextXML

inferred from PubMed Central ID database lookup

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Two German kindreds with familial amyotrophic lateral sclerosis due to TARDBP mutations

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Role of X11 and ubiquilin as in vivo regulators of the amyloid precursor protein in Drosophila

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Mitochondrial dysfunction in SOD1G93A-bearing astrocytes promotes motor neuron degeneration: prevention by mitochondrial-targeted antioxidants

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Herp enhances ER-associated protein degradation by recruiting ubiquilins

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TDP-43 regulates retinoblastoma protein phosphorylation through the repression of cyclin-dependent kinase 6 expression

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Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation

5 June 2018

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TDP-43: a novel neurodegenerative proteinopathy

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Studies of the role of ubiquitination in the interaction of ubiquilin with the loop and carboxyl terminal regions of presenilin-2

5 June 2018

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TDP-43 in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusions

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Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.

5 June 2018

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Potential therapeutic applications of autophagy

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Mechanisms of Disease: astrocytes in neurodegenerative disease

5 June 2018

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The UBL domain of PLIC-1 regulates aggresome formation

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Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

5 June 2018

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ALS: a disease of motor neurons and their nonneuronal neighbors

5 June 2018

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Dimerization of ubiquilin is dependent upon the central region of the protein: evidence that the monomer, but not the dimer, is involved in binding presenilins

5 June 2018

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Onset and progression in inherited ALS determined by motor neurons and microglia

5 June 2018

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Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway

5 June 2018

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Suppression of polyglutamine-induced toxicity in cell and animal models of Huntington's disease by ubiquilin

5 June 2018

1 reference

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Ubiquilin recruits Eps15 into ubiquitin-rich cytoplasmic aggregates via a UIM-UBL interaction

5 June 2018

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Ubiquilin regulates presenilin endoproteolysis and modulates gamma-secretase components, Pen-2 and nicastrin

5 June 2018

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Family-based association between Alzheimer's disease and variants in UBQLN1

5 June 2018

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Ubiquilin interacts with ubiquitylated proteins and proteasome through its ubiquitin-associated and ubiquitin-like domains

5 June 2018

1 reference

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Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

5 June 2018

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Motor neuron disease group accompanied by inclusions of unidentified protein signaled by ubiquitin

5 June 2018

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Kaposi's sarcoma-associated herpesvirus K7 protein targets a ubiquitin-like/ubiquitin-associated domain-containing protein to promote protein degradation

5 June 2018

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Overexpression of ubiquilin decreases ubiquitination and degradation of presenilin proteins

5 June 2018

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Structural studies of the interaction between ubiquitin family proteins and proteasome subunit S5a

5 June 2018

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Budding yeast Dsk2p is a polyubiquitin-binding protein that can interact with the proteasome

5 June 2018

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GABA(A) receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658102

Characterization and functional implications of the RNA binding properties of nuclear factor TDP-43, a novel splicing regulator of CFTR exon 9

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658102

Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658102

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658102

Identification and characterization of an ataxin-1-interacting protein: A1Up, a ubiquitin-like nuclear protein

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658102

The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658102

Slowing of axonal transport is a very early event in the toxicity of ALS-linked SOD1 mutants to motor neurons

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658102

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658102

Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658102

Systemic AAV6 delivery mediating RNA interference against SOD1: neuromuscular transduction does not alter disease progression in fALS mice.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658102

ubiquilin antagonizes presenilin and promotes neurodegeneration in Drosophila

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658102

The ubiquilin 1 gene and Alzheimer's disease.

18 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658102

Human, Drosophila, and C.elegans TDP43: nucleic acid binding properties and splicing regulatory function

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658102

Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658102

Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658102

The neuroprotective factor Wlds does not attenuate mutant SOD1-mediated motor neuron disease

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658102

Nuclear factor TDP-43 binds to the polymorphic TG repeats in CFTR intron 8 and causes skipping of exon 9: a functional link with disease penetrance

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658102

Wild-Type Nonneuronal Cells Extend Survival of SOD1 Mutant Motor Neurons in ALS Mice

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658102

Recognition of specific ubiquitin conjugates is important for the proteolytic functions of the ubiquitin-associated domain proteins Dsk2 and Rad23.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658102

Molecular cloning, chromosome mapping and characterization of UBQLN3 a testis-specific gene that contains an ubiquitin-like domain

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658102

Axonal transport of mutant superoxide dismutase 1 and focal axonal abnormalities in the proximal axons of transgenic mice.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658102

Inhibitory effect of modified bafilomycins and concanamycins on P- and V-type adenosinetriphosphatases.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658102

Consideration about negative controls for LC3 and expression vectors for four colored fluorescent protein-LC3 negative controls

18 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M808064200

Sixteen novel mutations in the Cu/Zn superoxide dismutase gene in amyotrophic lateral sclerosis: a decade of discoveries, defects and disputes

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M808064200

Acidification is essential for maintaining the structure and function of lytic granules of CTL. Effect of concanamycin A, an inhibitor of vacuolar type H(+)-ATPase, on CTL-mediated cytotoxicity

21 January 2018

1 reference

12 December 2020

Linkage of familial amyotrophic lateral sclerosis with frontotemporal dementia to chromosome 9q21-q22

1 reference

12 December 2020

Impairment of axonal transport in the axon hillock and the initial segment of anterior horn neurons in transgenic mice with a G93A mutant SOD1 gene

1 reference

12 December 2020

Autophagy induction rescues toxicity mediated by proteasome inhibition

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12 December 2020

Identifiers

DOI

10.1074/JBC.M808064200

1 reference

15 October 2017

1 reference

15 October 2017

PubMed publication ID

19112176

1 reference