(Q39671498)

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DNA methyltransferase inhibitor, zebularine, delays tumor growth and induces apoptosis in a genetically engineered mouse model of breast cancer

scientific article published on 27 December 2011

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scholarly article

1 reference

Europe PubMed Central

13 September 2017

DNA methyltransferase inhibitor, zebularine, delays tumor growth and induces apoptosis in a genetically engineered mouse model of breast cancer (English)

1 reference

Europe PubMed Central

13 September 2017

12

object named as

Patricia Steeg

1 reference

Europe PubMed Central

13 September 2017

author name string

Min Chen

1

1 reference

Europe PubMed Central

13 September 2017

Daniel Shabashvili

2

1 reference

Europe PubMed Central

13 September 2017

Akbar Nawab

3

1 reference

Europe PubMed Central

13 September 2017

Sherry X Yang

4

1 reference

Europe PubMed Central

13 September 2017

Lisa M Dyer

5

1 reference

Europe PubMed Central

13 September 2017

Kevin D Brown

6

1 reference

Europe PubMed Central

13 September 2017

Melinda Hollingshead

7

1 reference

Europe PubMed Central

13 September 2017

Kent W Hunter

8

1 reference

Europe PubMed Central

13 September 2017

Frederic J Kaye

9

1 reference

Europe PubMed Central

13 September 2017

Steven N Hochwald

10

1 reference

Europe PubMed Central

13 September 2017

Victor E Marquez

11

1 reference

Europe PubMed Central

13 September 2017

Maria Zajac-Kaye

13

1 reference

Europe PubMed Central

13 September 2017

publication date

27 December 2011

1 reference

Europe PubMed Central

13 September 2017

Molecular Cancer Therapeutics

1 reference

Europe PubMed Central

13 September 2017

11

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Europe PubMed Central

13 September 2017

370-382

1 reference

Europe PubMed Central

13 September 2017

2

1 reference

Europe PubMed Central

13 September 2017

Long-term epigenetic therapy with oral zebularine has minimal side effects and prevents intestinal tumors in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assessing therapeutic responses in Kras mutant cancers using genetically engineered mouse models

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p21 is necessary for the p53-mediated G1 arrest in human cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Wnt antagonist secreted frizzled-related protein-1 controls osteoblast and osteocyte apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methylation-associated silencing of SFRP1 with an 8p11-12 amplification inhibits canonical and non-canonical WNT pathways in breast cancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apigenin causes G(2)/M arrest associated with the modulation of p21(Cip1) and Cdc2 and activates p53-dependent apoptosis pathway in human breast cancer SK-BR-3 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The use of targeted mouse models for preclinical testing of novel cancer therapeutics.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polyomavirus middle-sized tumor antigen modulates c-Jun phosphorylation and transcriptional activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of a novel DNA methyltransferase inhibitor zebularine on human breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced growth inhibition by combined DNA methylation/HDAC inhibitors in lung tumor cells with silenced CDKN2A.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis, proliferation and differentiation patterns are influenced by Zebularine and SAHA in pancreatic cancer models

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methylation of the BRCA1 gene in sporadic breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Global expression profiling identifies signatures of tumor virulence in MMTV-PyMT-transgenic mice: correlation to human disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extracellular protease mRNAs are predominantly expressed in the stromal areas of microdissected mouse breast carcinomas.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inactivation of Wnt inhibitory factor-1 (WIF1) expression by epigenetic silencing is a common event in breast cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclin D2 expression in familial and sporadic breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhancement of in vitro and in vivo tumor cell radiosensitivity by the DNA methylation inhibitor zebularine

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Repression of transforming growth factor-beta receptor type I promoter expression by Sp1 deficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative two-dimensional gel analysis and microsequencing identifies gelsolin as one of the most prominent downregulated markers of transformed human fibroblast and epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of cyclin D2 expression in the majority of breast cancers is associated with promoter hypermethylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene expression profile and angiogenic marker correlates with response to neoadjuvant bevacizumab followed by bevacizumab plus chemotherapy in breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic role of apoptotic, Bcl-2, c-erbB-2 and p53 tumor markers in salivary gland malignancies

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preferential response of cancer cells to zebularine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The phosphatidyl inositol 3-kinase/AKT signaling pathway in breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Requirement for both Shc and phosphatidylinositol 3' kinase signaling pathways in polyomavirus middle T-mediated mammary tumorigenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synergistic induction of apoptosis in breast cancer cells by cotreatment with butyrate and TNF-alpha, TRAIL, or anti-Fas agonist antibody involves enhancement of death receptors' signaling and requires P21(waf1).

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The epigenomics of cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epigenetic suppression of secreted frizzled related protein 1 (SFRP1) expression in human breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression analysis of DNA methyltransferases 1, 3A, and 3B in sporadic breast carcinomas.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SARPs: a family of secreted apoptosis-related proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The use of GEM models for experimental cancer therapeutics

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative multiplex methylation-specific PCR assay for the detection of promoter hypermethylation in multiple genes in breast cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of 5-aza-2'-deoxycytidine against leukemic and hemopoietic tissues in AKR mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular differentiation, cytidine analogs and DNA methylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Widespread loss of gelsolin in breast cancers of humans, mice, and rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclin D2 activates Cdk2 in preference to Cdk4 in human breast epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of autophagy and inhibition of tumorigenesis by beclin 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aberrant methylation of secreted frizzled-related protein genes in esophageal adenocarcinoma and Barrett's esophagus

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of DNA methylation and reactivation of silenced genes by zebularine

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An essential role for DNA methyltransferase DNMT3B in cancer cell survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Zebularine: a new drug for epigenetic therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gelsolin as a negative prognostic factor and effector of motility in erbB-2-positive epidermal growth factor receptor-positive breast cancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation, characterization, and properties of a labile hydrolysis product of the antitumor nucleoside, 5-azacytidine

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Zebularine inhibits human acute myeloid leukemia cell growth in vitro in association with p15INK4B demethylation and reexpression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of mammary epithelial hyperplasias and mammary tumors in transgenic mice expressing a murine mammary tumor virus/activated c-src fusion gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Continuous zebularine treatment effectively sustains demethylation in human bladder cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression profiles of apoptotic genes induced by curcumin in human breast cancer and mammary epithelial cell lines.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/1535-7163.MCT-11-0458

1 reference

Europe PubMed Central

13 September 2017

1 reference

Europe PubMed Central

13 September 2017

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