(Q39674136)

English

A small difference in the molecular structure of angiotensin II receptor blockers induces AT1 receptor-dependent and -independent beneficial effects

scientific article published on July 29, 2010

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scholarly article

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Europe PubMed Central

PMC publication ID

13 September 2017

A small difference in the molecular structure of angiotensin II receptor blockers induces AT₁ receptor-dependent and -independent beneficial effects (English)

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

A small difference in the molecular structure of angiotensin II receptor blockers induces AT1 receptor-dependent and -independent beneficial effects (English)

1 reference

10.1038/HR.2010.135

https://api.crossref.org/works/10.1038/HR.2010.135

12 June 2024

molecular geometry

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author name string

Masahiro Fujino

1

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Shin-ichiro Miura

2

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Yoshihiro Kiya

3

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Yukio Tominaga

4

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Yoshino Matsuo

5

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Keijiro Saku

7

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Sadashiva S. Karnik

6

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20668453

12 June 2024

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29 July 2010

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13 September 2017

full work available at URL

https://www.nature.com/articles/hr2010135.pdf

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20668453

12 June 2024

http://www.jstage.jst.go.jp/article/hypres/33/10/1044/_pdf

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20668453

12 June 2024

http://www.jstage.jst.go.jp/article/hypres/33/10/33_1044/_article

online access status

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1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20668453

12 June 2024

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20668453/pdf/?tool=EBI

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1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20668453

12 June 2024

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20668453/?tool=EBI

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1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20668453

12 June 2024

https://europepmc.org/articles/PMC3891520

online access status

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Europe PubMed Central

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20668453

12 June 2024

https://europepmc.org/articles/PMC3891520?pdf=render

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online access status

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Europe PubMed Central

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20668453

12 June 2024

https://doi.org/10.1038/hr.2010.135

online access status

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20668453

12 June 2024

http://www.nature.com/articles/hr2010135.pdf

Portable Document Format

1 reference

10.1038/HR.2010.135

https://api.crossref.org/works/10.1038/HR.2010.135

12 June 2024

http://www.nature.com/articles/hr2010135

1 reference

10.1038/HR.2010.135

https://api.crossref.org/works/10.1038/HR.2010.135

12 June 2024

Hypertension Research

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

33

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

10

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

1044-1052

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

https://scigraph.springernature.com/pub.10.1038/hr.2010.135

0 references

Conformational switch of angiotensin II type 1 receptor underlying mechanical stress-induced activation

1 reference

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Differential bonding interactions of inverse agonists of angiotensin II type 1 receptor in stabilizing the inactive state

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3891520

14 September 2017

Common angiotensin receptor blockers may directly modulate the immune system via VDR, PPAR and CCR2b

1 reference

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14 September 2017

Structure-activity relationships of inverse agonists for G-protein-coupled receptors

1 reference

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14 September 2017

Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3891520

14 September 2017

Drugs targeting the renin-angiotensin-aldosterone system

1 reference

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14 September 2017

Role of peroxisome proliferator-activated receptor-gamma in maintenance of the characteristics of mature 3T3-L1 adipocytes

1 reference

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14 September 2017

Modeling of loops in protein structures

1 reference

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14 September 2017

Inverse agonist activity of atypical antipsychotic drugs at human 5-hydroxytryptamine2C receptors

1 reference

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14 September 2017

Induction of monocyte chemoattractant protein-1 by albumin is mediated by nuclear factor kappaB in proximal tubule cells

1 reference

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14 September 2017

Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas

1 reference

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14 September 2017

Defects in G protein-coupled signal transduction in human disease

1 reference

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25 September 2017

Telmisartan but not candesartan affects adiponectin expression in vivo and in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3891520

15 June 2018

PPARgamma-activating angiotensin type-1 receptor blockers induce adiponectin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3891520

15 June 2018

Angiotensin II type 1 receptor antagonists inhibit basal as well as low-density lipoprotein and platelet-activating factor-stimulated human monocyte chemoattractant protein-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3891520

15 June 2018

Constitutive activity of the human beta(1)-adrenergic receptor in beta(1)-receptor transgenic mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3891520

15 June 2018

Mechanism of constitutive activation of the AT1 receptor: influence of the size of the agonist switch binding residue Asn(111).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3891520

15 June 2018

Multivalent ligand-receptor interactions elicit inverse agonist activity of AT(1) receptor blockers against stretch-induced AT(1) receptor activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3891520

21 August 2018

Anti-inflammatory and metabolic effects of candesartan in hypertensive patients.

1 reference

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21 August 2018

The retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure

1 reference

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21 August 2018

Effects of losartan and valsartan on left ventricular hypertrophy and function in essential hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3891520

21 August 2018

Comparison of effects of losartan, irbesartan, and candesartan on flow-mediated brachial artery dilation and on inflammatory and thrombolytic markers in patients with systemic hypertension.

1 reference

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21 August 2018

Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3891520

21 August 2018

Angiotensin type 1 receptor blockers induce peroxisome proliferator-activated receptor-gamma activity

1 reference

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"Network leaning" as a mechanism of insurmountable antagonism of the angiotensin II type 1 receptor by non-peptide antagonists

1 reference

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Differing anti-proteinuric action of candesartan and losartan in chronic renal disease

1 reference

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Angiotensin II receptor-independent antiinflammatory and antiaggregatory properties of losartan: role of the active metabolite EXP3179.

1 reference

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Proposal of a New Binding Orientation for Non-Peptide AT1 Antagonists: Homology Modeling, Docking and Three-Dimensional Quantitative Structure−Activity Relationship Analysis

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IFNgamma induces functional chemokine receptor expression in human mesangial cells

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inferred from PubMed ID database lookup

Tetrazole and carboxylate groups of angiotensin receptor antagonists bind to the same subsite by different mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/20668453

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based on heuristic

inferred from PubMed ID database lookup

The active state of the AT1 angiotensin receptor is generated by angiotensin II induction

1 reference

https://pubmed.ncbi.nlm.nih.gov/20668453

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based on heuristic

inferred from PubMed ID database lookup

Dose-related antihypertensive effects of irbesartan in patients with mild-to-moderate hypertension

1 reference

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inferred from PubMed ID database lookup

Role of aromaticity of agonist switches of angiotensin II in the activation of the AT1 receptor

1 reference

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Angiotensin IV Activates the Nuclear Transcription Factor-κB and Related Proinflammatory Genes in Vascular Smooth Muscle Cells

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Molecular mechanism underlying inverse agonist of angiotensin II type 1 receptor

1 reference

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Inverse agonism and neutral antagonism at alpha(1a)- and alpha(1b)-adrenergic receptor subtypes

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based on heuristic

inferred from PubMed ID database lookup

Molecular Pharmacology

25

60

712

author name string

S Engelhardt

publication date

2001

1 reference

10.1038/HR.2010.135

https://api.crossref.org/works/10.1038/HR.2010.135

12 June 2024

Identifiers

10.1038/HR.2010.135

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

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