(Q39679544)

English

Anti-inflammatory action of exendin-4 in human islets is enhanced by phosphodiesterase inhibitors: potential therapeutic benefits in diabetic patients

scientific article published on 16 July 2010

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

Anti-inflammatory action of exendin-4 in human islets is enhanced by phosphodiesterase inhibitors: potential therapeutic benefits in diabetic patients (English)

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

0 references

author name string

U Pugazhenthi

1

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

K Velmurugan

2

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

A Tran

3

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

G Mahaffey

4

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

S Pugazhenthi

5

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

publication date

16 July 2010

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

53

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

11

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

2357-2368

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

https://scigraph.springernature.com/pub.10.1007/s00125-010-1849-y

0 references

Cutting edge: macrophage inhibition by cyclic AMP (cAMP): differential roles of protein kinase A and exchange protein directly activated by cAMP-1.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-010-1849-Y

21 January 2018

IL-1beta and IFN-gamma induce the expression of diverse chemokines and IL-15 in human and rat pancreatic islet cells, and in islets from pre-diabetic NOD mice.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-010-1849-Y

21 January 2018

Among CXCR3 chemokines, IFN-gamma-inducible protein of 10 kDa (CXC chemokine ligand (CXCL) 10) but not monokine induced by IFN-gamma (CXCL9) imprints a pattern for the subsequent development of autoimmune disease.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-010-1849-Y

21 January 2018

IP-10 and type 1 diabetes: a question of time and location.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20635178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antidiabetogenic effect of pentoxifylline is associated with systemic and target tissue modulation of cytokines and nitric oxide production.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20635178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exendin-4 improves reversal of diabetes in NOD mice treated with anti-CD3 monoclonal antibody by enhancing recovery of beta-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20635178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Theophylline protects against diabetes in BB rats and potentiates cyclosporine protection

1 reference

https://pubmed.ncbi.nlm.nih.gov/20635178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The immunobiology of interferon-gamma inducible protein 10 kD (IP-10): a novel, pleiotropic member of the C-X-C chemokine superfamily

1 reference

https://pubmed.ncbi.nlm.nih.gov/20635178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of pro-inflammatory cytokine receptor signalling by cAMP in vascular endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20635178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New therapeutic horizons: mapping the future of glycemic control with incretin-based therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/20635178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathological changes in the islet milieu precede infiltration of islets and destruction of beta-cells by autoreactive lymphocytes in a transgenic model of virus-induced IDDM.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20635178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exenatide blocks JAK1-STAT1 in pancreatic beta cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20635178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NF-kappaB-dependent synergistic regulation of CXCL10 gene expression by IL-1beta and IFN-gamma in human intestinal epithelial cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/20635178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dipeptidyl peptidase IV inhibition with MK0431 improves islet graft survival in diabetic NOD mice partially via T-cell modulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20635178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification

1 reference

https://pubmed.ncbi.nlm.nih.gov/20635178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Islet inflammation and CXCL10 in recent-onset type 1 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20635178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exendin-4 modulates diabetes onset in nonobese diabetic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20635178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation by cAMP of STAT1 activation in hepatic stellate cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20635178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pentoxifylline in the treatment of children with new-onset type I diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/20635178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Continuous stimulation of human glucagon-like peptide-1 (7-36) amide in a mouse model (NOD) delays onset of autoimmune type 1 diabetes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20635178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of cytokines and JAK-STAT activation by distinct signaling pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/20635178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemokines in pathology and medicine

1 reference

https://pubmed.ncbi.nlm.nih.gov/20635178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemokines--chemotactic cytokines that mediate inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20635178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overview of PDEs and their regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20635178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p48/STAT-1alpha-containing complexes play a predominant role in induction of IFN-gamma-inducible protein, 10 kDa (IP-10) by IFN-gamma alone or in synergy with TNF-alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/20635178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exendin-4 protects dopaminergic neurons by inhibition of microglial activation and matrix metalloproteinase-3 expression in an animal model of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20635178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of inflammation in insulitis and beta-cell loss in type 1 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20635178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dominant negative mutant forms of the cAMP response element binding protein induce apoptosis and decrease the anti-apoptotic action of growth factors in human islets.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20635178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytokine-mediated induction of anti-apoptotic genes that are linked to nuclear factor kappa-B (NF-kappaB) signalling in human islets and in a mouse beta cell line

1 reference

https://pubmed.ncbi.nlm.nih.gov/20635178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum concentrations of the interferon-gamma-inducible chemokine IP-10/CXCL10 are augmented in both newly diagnosed Type I diabetes mellitus patients and subjects at risk of developing the disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20635178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CXC chemokine ligand 10 neutralization suppresses the occurrence of diabetes in nonobese diabetic mice through enhanced beta cell proliferation without affecting insulitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20635178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combined treatment with lisofylline and exendin-4 reverses autoimmune diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20635178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemokines in islet allograft rejection

1 reference

https://pubmed.ncbi.nlm.nih.gov/20635178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased number of islet-associated macrophages in type 2 diabetes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20635178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Double-stranded RNA cooperates with interferon-gamma and IL-1 beta to induce both chemokine expression and nuclear factor-kappa B-dependent apoptosis in pancreatic beta-cells: potential mechanisms for viral-induced insulitis and beta-cell death in ty

1 reference

https://pubmed.ncbi.nlm.nih.gov/20635178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of the chemokine interferon-gamma-inducible protein-10 in human pancreatic islets during enterovirus infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/20635178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemical characterization of a gamma interferon-inducible cytokine (IP-10).

1 reference

https://pubmed.ncbi.nlm.nih.gov/20635178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The biology of incretin hormones

1 reference

https://pubmed.ncbi.nlm.nih.gov/20635178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20635178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The phosphodiesterase inhibitors pentoxifylline and rolipram prevent diabetes in NOD mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20635178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of viruses in type I diabetes: two distinct cellular and molecular pathogenic mechanisms of virus-induced diabetes in animals

1 reference

https://pubmed.ncbi.nlm.nih.gov/20635178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CXCL10 impairs beta cell function and viability in diabetes through TLR4 signaling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20635178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cure of overt diabetes in NOD mice by transient treatment with anti-lymphocyte serum and exendin-4.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20635178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucagon-like peptide-1 inhibits LPS-induced IL-1beta production in cultured rat astrocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20635178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms

1 reference

https://pubmed.ncbi.nlm.nih.gov/20635178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enterovirus infection, CXC chemokine ligand 10 (CXCL10), and CXCR3 circuit: a mechanism of accelerated beta-cell failure in fulminant type 1 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20635178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta cells are responsible for CXCR3-mediated T-cell infiltration in insulitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20635178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Islet inflammation in type 2 diabetes: from metabolic stress to therapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20635178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of coxsackievirus-induced damage to human pancreatic beta-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20635178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclic AMP phosphodiesterases of human and rat islets of Langerhans: contributions of types III and IV to the modulation of insulin secretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/20635178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00125-010-1849-Y

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

ResearchGate publication ID

0 references

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