(Q37437153)

20 August 2017

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title

The role of inflammation in insulitis and beta-cell loss in type 1 diabetes (English)

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20 August 2017

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Fernanda Ortis

3

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author name string

Décio L Eizirik

series ordinal

1

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PubMed ID

19352320

20 August 2017

Maikel L Colli

series ordinal

2

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PubMed ID

19352320

20 August 2017

language of work or name

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1 April 2009

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Nature Reviews Endocrinology

20 August 2017

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20 August 2017

5

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20 August 2017

4

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20 August 2017

219-226

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https://scigraph.springernature.com/pub.10.1038/nrendo.2009.21

20 August 2017

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Double-stranded RNA cooperates with interferon-gamma and IL-1 beta to induce both chemokine expression and nuclear factor-kappa B-dependent apoptosis in pancreatic beta-cells: potential mechanisms for viral-induced insulitis and beta-cell death in ty

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IL-1beta and IFN-gamma induce the expression of diverse chemokines and IL-15 in human and rat pancreatic islet cells, and in islets from pre-diabetic NOD mice.

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Deletion of STAT-1 pancreatic islets protects against streptozotocin-induced diabetes and early graft failure but not against late rejection

31 March 2020

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Use of a systems biology approach to understand pancreatic beta-cell death in Type 1 diabetes

31 March 2020

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31 March 2020

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31 March 2020

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Islet beta-cell death - fuel to sustain autoimmunity?

31 March 2020

1 reference

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Caspase-3-dependent beta-cell apoptosis in the initiation of autoimmune diabetes mellitus.

31 March 2020

1 reference

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Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.21

The role for endoplasmic reticulum stress in diabetes mellitus

31 March 2020

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Death-defying immunity: do apoptotic cells influence antigen processing and presentation?

31 March 2020

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Apoptotic cells deliver processed antigen to dendritic cells for cross-presentation

31 March 2020

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The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes

31 March 2020

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Pathogenesis of ankylosing spondylitis: current concepts

31 March 2020

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Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.21

Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.21

Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.21

Extent of beta cell destruction is important but insufficient to predict the onset of type 1 diabetes mellitus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.21

Insulin secretion in type 1 diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.21

Reversal of beta-cell suppression in vitro in pancreatic islets isolated from nonobese diabetic mice during the phase preceding insulin-dependent diabetes mellitus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.21

Role of infiltrating T cells for impaired glucose metabolism in pancreatic islets isolated from non-obese diabetic mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.21

Function of pancreatic islets isolated from a type 1 diabetic patient

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.21

Modification of adverse inflammation is required to cure new-onset type 1 diabetic hosts

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.21

Regeneration of pancreatic endocrine cells in interferon-gamma transgenic mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.21

Increased beta-cell proliferation and reduced mass before diabetes onset in the nonobese diabetic mouse.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.21

Effects of autoimmunity and immune therapy on beta-cell turnover in type 1 diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.21

Autoimmunity and beta cell regeneration in mouse and human type 1 diabetes: the peace is not enough

31 March 2020

1 reference

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Notch signaling: a mediator of beta-cell de-differentiation in diabetes?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.21

Discovery of Gene Networks Regulating Cytokine-Induced Dysfunction and Apoptosis in Insulin-Producing INS-1 Cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.21

Critical roles for macrophages in islet angiogenesis and maintenance during pancreatic degeneration

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.21

Increased number of islet-associated macrophages in type 2 diabetes.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.21

Repair of pancreatic beta-cells. A relevant phenomenon in early IDDM?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.21

Screening for insulitis in adult autoantibody-positive organ donors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.21

Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.21

Recognition of microorganisms and activation of the immune response

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.21

Pathogen recognition and innate immunity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.21

MDA5/RIG-I and virus recognition.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.21

A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.21

Trex1 prevents cell-intrinsic initiation of autoimmunity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.21

Islet-specific Th1, but not Th2, cells secrete multiple chemokines and promote rapid induction of autoimmune diabetes

31 March 2020

1 reference

12 December 2020

Beyond double-stranded RNA-type I IFN induction by 3pRNA and other viral nucleic acids

1 reference

12 December 2020

The CVB and etiology of type 1 diabetes

1 reference

12 December 2020

Double-stranded ribonucleic acid (RNA) induces beta-cell Fas messenger RNA expression and increases cytokine-induced beta-cell apoptosis

1 reference

12 December 2020

CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope

1 reference

12 December 2020

Beta cells are responsible for CXCR3-mediated T-cell infiltration in insulitis

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRENDO.2009.21

1 reference

20 August 2017

1 reference

PubMed ID

19352320