(Q36811126)

16 August 2017

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title

TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity (English)

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16 August 2017

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2

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16 August 2017

4

Bruce Beutler

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Argyrios N Theofilopoulos

16 August 2017

series ordinal

5

object named as

Argyrios N Theofilopoulos

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16 August 2017

Roberto Baccala

1

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16 August 2017

Dwight H Kono

series ordinal

3

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16 August 2017

language of work or name

English

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publication date

1 May 2007

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16 August 2017

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13

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16 August 2017

543-551

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16 August 2017

5

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https://scigraph.springernature.com/pub.10.1038/nm1590

16 August 2017

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cites work

Cutting edge: enhancement of antibody responses through direct stimulation of B and T cells by type I IFN.

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Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity

21 January 2018

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The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I.

21 January 2018

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Accelerated macrophage apoptosis induces autoantibody formation and organ damage in systemic lupus erythematosus.

21 January 2018

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IFN-α Skews Monocyte Differentiation into Toll-Like Receptor 7-Expressing Dendritic Cells with Potent Functional Activities

21 January 2018

1 reference

Plasmacytoid dendritic cells control TLR7 sensitivity of naive B cells via type I IFN.

21 January 2018

1 reference

Cellular and genetic mechanisms of self tolerance and autoimmunity

21 January 2018

1 reference

7 January 2021

IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors

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7 January 2021

Mechanisms of type-I- and type-II-interferon-mediated signalling

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7 January 2021

IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors

1 reference

7 January 2021

Type I interferons (alpha/beta) in immunity and autoimmunity

1 reference

7 January 2021

Type I interferon in systemic lupus erythematosus and other autoimmune diseases

1 reference

7 January 2021

Lupus-like disease and high interferon levels corresponding to trisomy of the type I interferon cluster on chromosome 9p

1 reference

7 January 2021

Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus

1 reference

7 January 2021

A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus

1 reference

7 January 2021

Type-I interferon receptor deficiency reduces lupus-like disease in NZB mice

1 reference

7 January 2021

Type I Interferon controls the onset and severity of autoimmune manifestations in lpr mice

1 reference

7 January 2021

Type I IFN protects against murine lupus

1 reference

7 January 2021

Interferon-beta: a therapeutic for autoimmune lupus in MRL-Faslpr mice

1 reference

7 January 2021

Interferons as pathogenic effectors in autoimmunity

1 reference

7 January 2021

T cell hyperactivity in lupus as a consequence of hyperstimulatory antigen-presenting cells

1 reference

7 January 2021

Dendritic cell apoptosis in the maintenance of immune tolerance

1 reference

7 January 2021

Impairment of T and B cell development by treatment with a type I interferon

1 reference

7 January 2021

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7 January 2021

Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large

1 reference

7 January 2021

Toll-like receptor control of the adaptive immune responses

1 reference

7 January 2021

Sorting out Toll signals.

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7 January 2021

Negative regulation of toll-like receptor-mediated immune responses

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7 January 2021

DisSARMing Toll-like receptor signaling

1 reference

7 January 2021

Toll-like receptors and RNA helicases: two parallel ways to trigger antiviral responses

1 reference

7 January 2021

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

1 reference

7 January 2021

5'-Triphosphate RNA is the ligand for RIG-I

1 reference

7 January 2021

RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates

1 reference

7 January 2021

Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus

1 reference

7 January 2021

Recognition of cytosolic DNA activates an IRF3-dependent innate immune response

1 reference

7 January 2021

Toll-like receptors in systemic autoimmune disease

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7 January 2021

The type I interferon system in systemic lupus erythematosus

1 reference

7 January 2021

Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8.

1 reference

7 January 2021

Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus

1 reference

7 January 2021

U1 small nuclear ribonucleoprotein immune complexes induce type I interferon in plasmacytoid dendritic cells through TLR7.

1 reference

7 January 2021

Autoantibodies make a U-turn: the toll hypothesis for autoantibody specificity

1 reference

7 January 2021

Endogenous TLR ligands and autoimmunity

1 reference

7 January 2021

Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes.

1 reference

7 January 2021

Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9.

1 reference

7 January 2021

A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA.

1 reference

7 January 2021

Intracellular mammalian DNA stimulates myeloid dendritic cells to produce type I interferons predominantly through a toll-like receptor 9-independent pathway

1 reference

7 January 2021

Nucleosome, the Main Autoantigen in Systemic Lupus Erythematosus, Induces Direct Dendritic Cell Activation via a MyD88-Independent Pathway: Consequences on Inflammation

1 reference

7 January 2021

TLR9-independent activation of B lymphocytes by bacterial DNA.

1 reference

7 January 2021

The specific and essential role of MAVS in antiviral innate immune responses

1 reference

7 January 2021

Features of systemic lupus erythematosus in Dnase1-deficient mice

1 reference

7 January 2021

DNaseI in pathogenesis of systemic lupus erythematosus

1 reference

7 January 2021

Novel DNASE I mutations related to systemic lupus erythematosus

1 reference

7 January 2021

Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA

1 reference

7 January 2021

Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation

1 reference

7 January 2021

Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages

1 reference

7 January 2021

Efficient T cell activation via a Toll-Interleukin 1 Receptor-independent pathway

1 reference

7 January 2021

Nod-like proteins in immunity, inflammation and disease

1 reference

7 January 2021

Apoptosis in systemic lupus erythematosus. Clinical implications

1 reference

7 January 2021

Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies

1 reference

7 January 2021

Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family

1 reference

7 January 2021

Systemic exposure to irradiated apoptotic cells induces autoantibody production

1 reference

7 January 2021

Adiponectin modulates inflammatory reactions via calreticulin receptor-dependent clearance of early apoptotic bodies.

1 reference

7 January 2021

Natural adjuvants: endogenous activators of dendritic cells

1 reference

7 January 2021

Apoptotic vesicles crossprime CD8 T cells and protect against tuberculosis.

1 reference

7 January 2021

Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs

1 reference

7 January 2021

Calreticulin exposure dictates the immunogenicity of cancer cell death

1 reference

7 January 2021

Activation of antigen-presenting cells by microbial products breaks self tolerance and induces autoimmune disease

1 reference

7 January 2021

Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease

1 reference

7 January 2021

Immunoprivileged status of the liver is controlled by Toll-like receptor 3 signaling

1 reference

7 January 2021

Dendritic cell-induced autoimmune heart failure requires cooperation between adaptive and innate immunity

1 reference

7 January 2021

CpG motifs in bacterial DNA and their immune effects

1 reference

7 January 2021

Epstein-Barr virus and molecular mimicry in systemic lupus erythematosus

1 reference

7 January 2021

Microbial nucleic acids pay a Toll in kidney disease.

1 reference

7 January 2021

IFN-alpha induces early lethal lupus in preautoimmune (New Zealand Black x New Zealand White) F1 but not in BALB/c mice

1 reference

7 January 2021

Induction of murine autoimmune disease by chronic polyclonal B cell activation

1 reference

7 January 2021

Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus

1 reference

7 January 2021

TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE.

1 reference

7 January 2021

Toll-like receptor 9 signaling protects against murine lupus

1 reference

7 January 2021

Role of TLR9 in anti-nucleosome and anti-DNA antibody production in lpr mutation-induced murine lupus

1 reference

7 January 2021

Toll-like receptor 9-independent aggravation of glomerulonephritis in a novel model of SLE

1 reference

7 January 2021

Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus.

1 reference

7 January 2021

Lupus glomerulonephritis revisited 2004: autoimmunity and end-organ damage.

1 reference

7 January 2021

RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement.

1 reference

7 January 2021

Toll-like receptor 7-dependent loss of B cell tolerance in pathogenic autoantibody knockin mice

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7 January 2021

Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication

1 reference

7 January 2021

A Tlr7 translocation accelerates systemic autoimmunity in murine lupus

1 reference

7 January 2021

The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9

1 reference

7 January 2021

Suppressive oligodeoxynucleotides delay the onset of glomerulonephritis and prolong survival in lupus-prone NZB × NZW mice

1 reference

7 January 2021

Therapeutic targeting of pattern-recognition receptors

1 reference

7 January 2021

Mechanisms of Disease: primary Sjögren's syndrome and the type I interferon system

1 reference

7 January 2021

Neutralizing interferon alpha as a therapeutic approach to autoimmune diseases

1 reference

7 January 2021

Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production.

1 reference

7 January 2021

Type I interferon-associated skin recruitment of CXCR3+ lymphocytes in dermatomyositis

1 reference

7 January 2021

'Toll' gates for future immunotherapy

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7 January 2021

Identifiers

DOI

10.1038/NM1590

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16 August 2017

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