(Q36148399)

12 August 2017

1 reference

title

Cellular and genetic mechanisms of self tolerance and autoimmunity (English)

1 reference

Barbara Fazekas De St Groth

12 August 2017

author

object named as

Barbara Fazekas de St Groth

3

0 references

Carola Garcia de Vinuesa

object named as

Carola G Vinuesa

4

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author name string

Christopher C Goodnow

1

1 reference

12 August 2017

Jonathon Sprent

2

1 reference

12 August 2017

language of work or name

English

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publication date

1 June 2005

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12 August 2017

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12 August 2017

volume

435

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12 August 2017

issue

7042

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12 August 2017

page(s)

590-597

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The repertoire of T cells shaped by a single MHC/peptide ligand.

12 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

The MHC reactivity of the T cell repertoire prior to positive and negative selection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Predominant autoantibody production by early human B cell precursors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Epidemiology and estimated population burden of selected autoimmune diseases in the United States

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Antigen receptor selection by editing or downregulation of V(D)J recombination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Positive versus negative signaling by lymphocyte antigen receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Self-tolerance: context dependent tuning of T cell antigen recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Elimination of self-reactive B lymphocytes proceeds in two stages: arrested development and cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

The regulation of lupus-associated autoantibodies: immunoglobulin transgenic models

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

BAFF AND APRIL: a tutorial on B cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

RAGs and regulation of autoantibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

The control of apoptosis in lymphocyte selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Self-reactive B cells are not eliminated or inactivated by autoantigen expressed on thyroid epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Negative selection--clearing out the bad apples from the T-cell repertoire

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Perinatal blockade of b7-1 and b7-2 inhibits clonal deletion of highly pathogenic autoreactive T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Autoreactivity of T cells from nonobese diabetic mice: an I-Ag7-dependent reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Genetic control of autoimmune diabetes in the NOD mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Development of spontaneous autoimmune peripheral polyneuropathy in B7-2-deficient NOD mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Positional cloning of the APECED gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Aire deficient mice develop multiple features of APECED phenotype and show altered immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Projection of an immunological self shadow within the thymus by the aire protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Aire regulates negative selection of organ-specific T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Gene dosage--limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Peripheral-antigen-expressing cells in thymic medulla: factors in self-tolerance and autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Scenarios for autoimmunization of T and B cells in myasthenia gravis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Disruption of T cell signaling networks and development by Grb2 haploid insufficiency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Signaling by the kinase MINK is essential in the negative selection of autoreactive thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Failure to censor forbidden clones of CD4 T cells in autoimmune diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Enhanced pathogenicity of diabetogenic T cells escaping a non-MHC gene-controlled near death experience.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

It's all Rel-ative: NF-kappaB and CD28 costimulation of T-cell activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Negative selection of semimature CD4(+)8(-)HSA+ thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Human autoimmune lymphoproliferative syndrome, a defect in the apoptosis-inducing Fas receptor: a lesson from the mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Activation and anergy in bone marrow B cells of a novel immunoglobulin transgenic mouse that is both hapten specific and autoreactive.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Immune inhibitory receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

CD5 maintains tolerance in anergic B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Dynamic tuning of T cell reactivity by self-peptide-major histocompatibility complex ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Sensory adaptation in naive peripheral CD4 T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

21 January 2018

The B7-CD28 superfamily

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

The enemy within: keeping self-reactive T cells at bay in the periphery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

GRAIL: an E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Ubiquitin ligases and the immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Excess BAFF rescues self-reactive B cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone niches.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

BAFF-induced NEMO-independent processing of NF-kappa B2 in maturing B cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Control of T cell viability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

T cell regulation as a side effect of homeostasis and competition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Artemis sheds new light on V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Autoimmunity in Wiskott-Aldrich syndrome: risk factors, clinical features, and outcome in a single-center cohort of 55 patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Lymphopenia in the BB rat model of type 1 diabetes is due to a mutation in a novel immune-associated nucleotide (Ian)-related gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Homeostatic expansion of T cells during immune insufficiency generates autoimmunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Immune regulation by CD40 and its ligand GP39.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Cytokines and immunodeficiency diseases: critical roles of the gamma(c)-dependent cytokines interleukins 2, 4, 7, 9, 15, and 21, and their signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

The Guillain-Barré syndrome: a true case of molecular mimicry

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Inferences, questions and possibilities in Toll-like receptor signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

DNA methylation and autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Genetic and structural evidence for antigen selection of anti-DNA antibodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Pathogenic autoantibodies are routinely generated during the response to foreign antigen: a paradigm for autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Humoral immunity due to long-lived plasma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Ectopic lymphoid organogenesis: a fast track for autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Despite ubiquitous autoantigen expression, arthritogenic autoantibody response initiates in the local lymph node

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Antigen-induced B-cell death and elimination during germinal-centre immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Soluble antigen can cause enhanced apoptosis of germinal-centre B cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Emerging paradigms of T-cell co-stimulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Co-stimulation and selection for T-cell help for germinal centres: the role of CD28 and OX40.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

SAP is required for generating long-term humoral immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Autoantibodies as predictors of disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Staging the initiation of autoantibody-induced arthritis: a critical role for immune complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

The role of antibodies in mouse models of rheumatoid arthritis, and relevance to human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

A defect in central tolerance in NOD mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

7 January 2021

The thymus and negative selection

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

7 January 2021

A selective defect in IgM antigen receptor synthesis and transport causes loss of cell surface IgM expression on tolerant B lymphocytes.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

7 January 2021

Resistance to CpG DNA-induced autoimmunity through tolerogenic B cell antigen receptor ERK signaling

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

7 January 2021

CTLA-4 engagement acts as a brake on CD4+ T cell proliferation and cytokine production but is not required for tuning T cell reactivity in adaptive tolerance

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

7 January 2021

Cblb is a major susceptibility gene for rat type 1 diabetes mellitus

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

7 January 2021

Pulsed monoclonal antibody treatment and autoimmune thyroid disease in multiple sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

7 January 2021

The diabetes-prone BB rat carries a frameshift mutation in Ian4, a positional candidate of Iddm1

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

7 January 2021

Clearing the way to mechanisms of autoimmunity

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03724

7 January 2021

Identifiers

DOI

10.1038/NATURE03724

1 reference

12 August 2017

1 reference