(Q35951801)

English

Cytokines and immunodeficiency diseases: critical roles of the gamma(c)-dependent cytokines interleukins 2, 4, 7, 9, 15, and 21, and their signaling pathways

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scholarly article

1 reference

Europe PubMed Central

11 August 2017

1 reference

Europe PubMed Central

Cytokines and immunodeficiency diseases: critical roles of the gamma(c)-dependent cytokines interleukins 2, 4, 7, 9, 15, and 21, and their signaling pathways (English)

1 reference

Europe PubMed Central

11 August 2017

author name string

Panu E Kovanen

1

1 reference

Europe PubMed Central

11 August 2017

Warren J Leonard

2

1 reference

Europe PubMed Central

11 August 2017

publication date

1 December 2004

1 reference

Europe PubMed Central

11 August 2017

Immunological Reviews

1 reference

Europe PubMed Central

11 August 2017

202

1 reference

Europe PubMed Central

11 August 2017

67-83

1 reference

Europe PubMed Central

11 August 2017

Naturally occurring primary deficiencies of the immune system

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

A critical role for IL-21 in regulating immunoglobulin production

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain.

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Interferon-gamma-receptor deficiency in an infant with fatal bacille Calmette-Guérin infection

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

A mutation in the interferon-gamma-receptor gene and susceptibility to mycobacterial infection

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Partial Interferon‐γ Receptor Signaling Chain Deficiency in a Patient with Bacille Calmette‐Guérin andMycobacterium abscessusInfection

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Impairment of mycobacterial but not viral immunity by a germline human STAT1 mutation

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Jaks and STATs: biological implications

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

The lineage decisions of helper T cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

The interleukin-2 receptor gamma chain: its role in the multiple cytokine receptor complexes and T cell development in XSCID

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

The molecular basis of X-linked severe combined immunodeficiency: defective cytokine receptor signaling

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Human immune disorder arising from mutation of the alpha chain of the interleukin-2 receptor

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Homeostasis and self-tolerance in the immune system: turning lymphocytes off.

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Mature T lymphocyte apoptosis--immune regulation in a dynamic and unpredictable antigenic environment

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

An inherited disorder of lymphocyte apoptosis: the autoimmune lymphoproliferative syndrome

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Regulatory T cells: key controllers of immunologic self-tolerance

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Regulatory T cells in autoimmmunity*.

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

The role of suppressor T cells in regulation of immune responses

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency.

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Interleukin 2 signaling is required for CD4(+) regulatory T cell function

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Loss of Tolerance and Autoimmunity Affecting Multiple Organs inSTAT5A/5B-Deficient Mice

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Interleukin 2 plays a central role in Th2 differentiation.

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

The role of cytokine receptor signaling in lymphocyte development

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Interleukin-7: physiological roles and mechanisms of action

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Interleukin-7: from bench to clinic

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Stimulation of B-cell progenitors by cloned murine interleukin-7

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Interleukin-7: master regulator of peripheral T-cell homeostasis?

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Cytokine control of memory T-cell development and survival

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

IL-7 is critical for homeostatic proliferation and survival of naive T cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Overexpression of interleukin (IL)-7 leads to IL-15-independent generation of memory phenotype CD8+ T cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Interleukin (IL)-15 and IL-7 jointly regulate homeostatic proliferation of memory phenotype CD8+ cells but are not required for memory phenotype CD4+ cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Regulating the immune response to transplants. a role for CD4+ regulatory cells?

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Abnormal development of intestinal intraepithelial lymphocytes and peripheral natural killer cells in mice lacking the IL-2 receptor beta chain

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Cutting edge: requirement for IL-15 in the generation of primary and memory antigen-specific CD8 T cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

IL-2-induced activation-induced cell death is inhibited in IL-15 transgenic mice

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

A role for Stat5 in CD8+ T cell homeostasis.

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

The molecular basis of T helper 1 and T helper 2 cell differentiation

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice.

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Stat6 is required for mediating responses to IL-4 and for development of Th2 cells.

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Essential role of Stat6 in IL-4 signalling

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

IL-13 effector functions

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

The IL-4 receptor: signaling mechanisms and biologic functions

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Cytokine signaling in 2002: new surprises in the Jak/Stat pathway

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Of genes and phenotypes: the immunological and molecular spectrum of combined immune deficiency. Defects of the gamma(c)-JAK3 signaling pathway as a model

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Interferon-alpha-dependent activation of Tyk2 requires phosphorylation of positive regulatory tyrosines by another kinase

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Complex effects of naturally occurring mutations in the JAK3 pseudokinase domain: evidence for interactions between the kinase and pseudokinase domains

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Mutation in the Jak kinase JH2 domain hyperactivates Drosophila and mammalian Jak-Stat pathways

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

The amino-terminal portion of the JAK2 protein kinase is necessary for binding and phosphorylation of the granulocyte-macrophage colony-stimulating factor receptor beta c chain

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Autosomal SCID caused by a point mutation in the N-terminus of Jak3: mapping of the Jak3-receptor interaction domain

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Signaling by type I and II cytokine receptors: ten years after

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Stat5b is essential for natural killer cell-mediated proliferation and cytolytic activity

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Growth signal transduction by the human interleukin-2 receptor requires cytoplasmic tyrosines of the beta chain and non-tyrosine residues of the gamma c chain.

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15.

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Different interleukin 2 receptor beta-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferation

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Identification and characterization of a constitutively active STAT5 mutant that promotes cell proliferation

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Transcriptional regulation of the cyclin D1 promoter by STAT5: its involvement in cytokine-dependent growth of hematopoietic cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Stat5 and Sp1 regulate transcription of the cyclin D2 gene in response to IL-2.

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Targeted inactivation of the IL-4 receptor alpha chain I4R motif promotes allergic airway inflammation

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

IL-21 in synergy with IL-15 or IL-18 enhances IFN-gamma production in human NK and T cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Roles of STAT3 defined by tissue-specific gene targeting

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Protein kinase B (Akt) regulation and function in T lymphocytes

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

IL-2 and related cytokines can promote T cell survival by activating AKT.

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Cellular survival: a play in three Akts

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

MAP kinases in the immune response

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

GTPases and T cell activation

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Transgenic analysis of thymocyte signal transduction

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

DNA array analysis of interleukin-2-regulated immediate/early genes

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

IL-15 mimics T cell receptor crosslinking in the induction of cellular proliferation, gene expression, and cytotoxicity in CD8+ memory T cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Transcript imaging of the development of human T helper cells using oligonucleotide arrays

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Identification of novel IL-4/Stat6-regulated genes in T lymphocytes.

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine.

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Suppressor of cytokine signaling 1 regulates IL-15 receptor signaling in CD8+CD44high memory T lymphocytes.

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Protein phosphatases and the regulation of mitogen-activated protein kinase signalling.

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Hematopoietic stem-cell transplantation for the treatment of severe combined immunodeficiency.

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

A second human interleukin-2 binding protein that may be a component of high-affinity interleukin-2 receptors

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00203.X

21 January 2018

Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death

1 reference

12 January 2024

https://opencitations.net/index/api/v1/citations/10.1016/S1074-7613(00)80103-X

Autoimmunity as the consequence of a spontaneous mutation in Rasgrp1.

1 reference

9 February 2024

https://opencitations.net/index/api/v1/citations/10.1016/S1074-7613(03)00209-7

Identifiers

10.1111/J.0105-2896.2004.00203.X

1 reference

Europe PubMed Central

11 August 2017

1 reference

Europe PubMed Central

11 August 2017

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