(Q34572219)

3 August 2017

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title

Transgenic analysis of thymocyte signal transduction (English)

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3 August 2017

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3 August 2017

1 January 2002

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Nature Reviews Immunology

3 August 2017

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3 August 2017

2

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3 August 2017

20-27

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3 August 2017

1

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The MAP kinase pathway controls differentiation from double-negative to double-positive thymocyte.

3 August 2017

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The use of dominant-negative mutations to elucidate signal transduction pathways in lymphocytes.

21 January 2018

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MAP-kinase signaling pathways in T cells

21 January 2018

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Functional dissection of the lck proximal promoter

21 January 2018

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The regulation of CD4 and CD8 coreceptor gene expression during T cell development

21 January 2018

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Essential role for protein kinase B (PKB) in insulin-induced glycogen synthase kinase 3 inactivation. Characterization of dominant-negative mutant of PKB.

21 January 2018

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The broad specificity of dominant inhibitory protein kinase C mutants infers a common step in phosphorylation.

21 January 2018

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Transcriptional regulation of T lymphocyte development and function

21 January 2018

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c-Myb regulates the proliferation of immature thymocytes following beta-selection

21 January 2018

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A dominant interfering Myb mutant causes apoptosis in T cells

21 January 2018

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A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes

21 January 2018

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FADD/MORT1 regulates the pre-TCR checkpoint and can function as a tumour suppressor

21 January 2018

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Effects of a dominant interfering mutant of FADD on signal transduction in activated T cells.

21 January 2018

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Ras regulation and function in lymphocytes.

21 January 2018

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T cell activation and the cytoskeleton

21 January 2018

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Protein kinase B localization and activation differentially affect S6 kinase 1 activity and eukaryotic translation initiation factor 4E-binding protein 1 phosphorylation

21 January 2018

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Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo

21 January 2018

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The dynamics of protein kinase B regulation during B cell antigen receptor engagement

21 January 2018

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An activated lck transgene promotes thymocyte development in RAG-1 mutant mice.

21 January 2018

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Distinct signals mediate maturation and allelic exclusion in lymphocyte progenitors

21 January 2018

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Activated Ras signals differentiation and expansion of CD4+8+ thymocytes

21 January 2018

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p56lck signals for regulating thymocyte development can be distinguished by their dependency on Rho function

21 January 2018

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The GTPase rho controls a p53-dependent survival checkpoint during thymopoiesis

21 January 2018

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Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade

21 January 2018

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Rho GTPases and their effector proteins

21 January 2018

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Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+ CD8+ thymocytes

21 January 2018

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The earliest T lineage-committed cells depend on IL-7 for Bcl-2 expression and normal cell cycle progression

21 January 2018

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Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/- mice

21 January 2018

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Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice

21 January 2018

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Pleiotropic changes controlled by the pre-T-cell receptor

21 January 2018

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Thymocyte development in the absence of pre-T cell receptor extracellular immunoglobulin domains

21 January 2018

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Control of early thymocyte development by the pre-T cell receptor complex: A receptor without a ligand?

21 January 2018

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Restoration of thymopoiesis in pT alpha-/- mice by anti-CD3epsilon antibody treatment or with transgenes encoding activated Lck or tailless pT alpha.

21 January 2018

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Exit of the pre-TCR from the ER/cis-Golgi is necessary for signaling differentiation, proliferation, and allelic exclusion in immature thymocytes.

21 January 2018

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Different initiation of pre-TCR and gammadeltaTCR signalling

21 January 2018

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The biological activity of natural and mutant pTalpha alleles

21 January 2018

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Transcriptional activation by tetracyclines in mammalian cells

21 January 2018

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A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins

21 January 2018

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Construction and characterization of a conditionally active version of the serine/threonine kinase Akt.

21 January 2018

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Knockout mice: a paradigm shift in modern immunology

21 January 2018

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Conditional Gene Knockout Using Cre Recombinase

21 January 2018

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Site- and time-specific gene targeting in the mouse

21 January 2018

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A pertussis toxin-sensitive process controls thymocyte emigration

21 January 2018

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The GTPase Rho has a critical regulatory role in thymus development

21 January 2018

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Ras and Rap1: two highly related small GTPases with distinct function

21 January 2018

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Rac-1 regulates nuclear factor of activated T cells (NFAT) C1 nuclear translocation in response to Fcepsilon receptor type 1 stimulation of mast cells

21 January 2018

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Selective requirement for MAP kinase activation in thymocyte differentiation.

21 January 2018

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Positive and negative selection invoke distinct signaling pathways.

21 January 2018

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Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice

21 January 2018

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Expression of the p56(Lck) Y505F mutation in CD45-deficient mice rescues thymocyte development

21 January 2018

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Activated p56lck directs maturation of both CD4 and CD8 single-positive thymocytes

21 January 2018

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Multiple pathways control protein kinase C phosphorylation

21 January 2018

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Protein kinase D. A selective target for antigen receptors and a downstream target for protein kinase C in lymphocytes

21 January 2018

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Activation loop Ser744 and Ser748 in protein kinase D are transphosphorylated in vivo.

21 January 2018

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Expression of Active Protein Kinase B in T Cells Perturbs Both T and B Cell Homeostasis and Promotes Inflammation

21 January 2018

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Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor

21 January 2018

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bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

21 January 2018

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DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2

21 January 2018

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Long-Term Survival But Impaired Homeostatic Proliferation of Naive T Cells in the Absence of p56lck

21 January 2018

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Distinct roles of the phosphatidylinositol 3-kinase and STAT5 pathways in IL-7-mediated development of human thymocyte precursors

21 January 2018

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Improved version of a human CD2 minigene based vector for T cell-specific expression in transgenic mice

31 March 2020

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Inhibition of Rho at different stages of thymocyte development gives different perspectives on Rho function

31 March 2020

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Control of pre-T cell proliferation and differentiation by the GTPase Rac-1

31 March 2020

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NF-kappa B activation by the pre-T cell receptor serves as a selective survival signal in T lymphocyte development

31 March 2020

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NF-kappa B is required for the positive selection of CD8+ thymocytes

31 March 2020

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Multiple p21ras effector pathways regulate nuclear factor of activated T cells.

31 March 2020

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Protein kinase B (Akt) regulation and function in T lymphocytes

31 March 2020

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Protein tyrosine kinase p56 lck controls allelic exclusion of T-cell receptor β-chain genes

31 March 2020

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Rho GTPases and their effector proteins

31 March 2020

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A Requirement for the Rho-Family GTP Exchange Factor Vav in Positive and Negative Selection of Thymocytes

31 March 2020

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Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis

31 March 2020

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bcl-2 transgene expression promotes survival and reduces proliferation of CD3-CD4-CD8- T cell progenitors

31 March 2020

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Different functions of the GTPase Rho in prothymocytes and late pre-T cells

31 March 2020

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Tetracycline-controllable selection of CD4(+) T cells: half-life and survival signals in the absence of major histocompatibility complex class II molecules

31 March 2020

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Inducible Expression of a p56Lck Transgene Reveals a Central Role for Lck in the Differentiation of CD4 SP Thymocytes

31 March 2020

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Reversible activation of c-Myc in skin: induction of a complex neoplastic phenotype by a single oncogenic lesion

31 March 2020

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Dissection of thymocyte signaling pathways by in vivo expression of pertussis toxin ADP-ribosyltransferase.

31 March 2020

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RasGRP: the missing link for Ras activation in thymocytes

31 March 2020

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Raf regulates positive selection

31 March 2020

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Analysis of the role of protein kinase C-alpha, -epsilon, and -zeta in T cell activation

31 March 2020

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Characterization of serine 916 as an in vivo autophosphorylation site for protein kinase D/Protein kinase Cmu

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI703

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3 August 2017

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PubMed ID

11905834