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English
Control of pre-T cell proliferation and differentiation by the GTPase Rac-1
scientific article published on 01 October 2000
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
11017108
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11017108%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 October 2019
title
Control of pre-T cell proliferation and differentiation by the GTPase Rac-I
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
11017108
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11017108%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 October 2019
main subject
immunology
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author
Victor Tybulewicz
object named as
Victor Tybulewicz
series ordinal
2
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author name string
Gomez M
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
11017108
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11017108%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 October 2019
Tybulewicz V
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed ID
11017108
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11017108%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 October 2019
Cantrell DA
series ordinal
3
1 reference
stated in
Europe PubMed Central
PubMed ID
11017108
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11017108%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 October 2019
publication date
1 October 2000
1 reference
stated in
Europe PubMed Central
PubMed ID
11017108
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11017108%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 October 2019
published in
Nature Immunology
1 reference
stated in
Europe PubMed Central
PubMed ID
11017108
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11017108%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 October 2019
volume
1
1 reference
stated in
Europe PubMed Central
PubMed ID
11017108
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11017108%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 October 2019
issue
4
1 reference
stated in
Europe PubMed Central
PubMed ID
11017108
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11017108%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 October 2019
page(s)
348-352
1 reference
stated in
Europe PubMed Central
PubMed ID
11017108
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11017108%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 October 2019
cites work
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Pleiotropic changes controlled by the pre-T-cell receptor
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7 January 2021
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T-cell selection
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7 January 2021
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Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product
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A Requirement for the Rho-Family GTP Exchange Factor Vav in Positive and Negative Selection of Thymocytes
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T cell activation and the cytoskeleton
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Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor
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Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction
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The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-kappaB pathways
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A guanine nucleotide exchange factor-independent function of Vav1 in transcriptional activation
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Vav modulation of the Ras/MEK/ERK signaling pathway plays a role in NFAT activation and CD69 up-regulation
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Multiple p21ras effector pathways regulate nuclear factor of activated T cells.
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p21ras initiates Rac-1 but not phosphatidyl inositol 3 kinase/PKB, mediated signaling pathways in T lymphocytes
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The T-cell receptor regulates Akt (protein kinase B) via a pathway involving Rac1 and phosphatidylinositide 3-kinase
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A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases
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Pak to the future
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Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
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Rho GTPases and the actin cytoskeleton
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Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade
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Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways
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Activated Ras signals differentiation and expansion of CD4+8+ thymocytes
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Evidence for a differential avidity model of T cell selection in the thymus
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Positive and negative thymocyte selection induced by different concentrations of a single peptide
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Identifiers
DOI
10.1038/79808
1 reference
stated in
Europe PubMed Central
PubMed ID
11017108
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11017108%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 October 2019
PubMed ID
11017108
1 reference
stated in
Europe PubMed Central
PubMed ID
11017108
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11017108%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 October 2019
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