(Q34572115)

3 August 2017

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title

Knockout mice: a paradigm shift in modern immunology (English)

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3 August 2017

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2

Penninger JM

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3 August 2017

Mak TW

1

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3 August 2017

Ohashi PS

series ordinal

3

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3 August 2017

publication date

1 October 2001

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Nature Reviews Immunology

3 August 2017

published in

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3 August 2017

volume

1

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3 August 2017

issue

1

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3 August 2017

page(s)

11-19

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Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells.

3 August 2017

cites work

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Beta 2-microglobulin deficient mice lack CD4-8+ cytolytic T cells.

21 January 2018

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CD8 is needed for development of cytotoxic T cells but not helper T cells

21 January 2018

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A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene

21 January 2018

1 reference

RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development

21 January 2018

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Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting

21 January 2018

1 reference

Brca1 required for T cell lineage development but not TCR loci rearrangement.

21 January 2018

1 reference

Inducible gene targeting in mice

21 January 2018

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Memory B-cell persistence is independent of persisting immunizing antigen.

21 January 2018

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Bias in the expression of IL-4 alleles: the use of T cells from a GFP knock-in mouse.

21 January 2018

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B lymphocytes producing demyelinating autoantibodies: development and function in gene-targeted transgenic mice

21 January 2018

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An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity

21 January 2018

1 reference

T cell receptor antagonist peptides induce positive selection

21 January 2018

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Evidence for a differential avidity model of T cell selection in the thymus

21 January 2018

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Differential requirements for survival and proliferation of CD8 naïve or memory T cells

21 January 2018

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Caspase knockouts: matters of life and death.

21 January 2018

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Transcriptional regulation of Th1/Th2 polarization

21 January 2018

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Chemokines as regulators of T cell differentiation.

21 January 2018

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The molecular basis of T helper 1 and T helper 2 cell differentiation

21 January 2018

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Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens

21 January 2018

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Cell death control in lymphocytes.

21 January 2018

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Environmental control of immunological synapse formation and duration

21 January 2018

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Role of Jak kinases and STATs in cytokine signal transduction

21 January 2018

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21 January 2018

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Regulation of T cell fate by Notch

21 January 2018

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Profound block in thymocyte development in mice lacking p56lck

21 January 2018

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Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages

21 January 2018

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RAG-1-deficient mice have no mature B and T lymphocytes

21 January 2018

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RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

21 January 2018

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Early alpha beta T cell development in the thymus of normal and genetically altered mice

21 January 2018

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Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn

21 January 2018

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alpha beta T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases

21 January 2018

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Csk controls antigen receptor-mediated development and selection of T-lineage cells.

21 January 2018

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Autonomous maturation of alpha/beta T lineage cells in the absence of COOH-terminal Src kinase (Csk).

21 January 2018

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The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling

21 January 2018

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Essential role for ZAP-70 in both positive and negative selection of thymocytes

21 January 2018

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Disruption of epithelial gamma delta T cell repertoires by mutation of the Syk tyrosine kinase

21 January 2018

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Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development

21 January 2018

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Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76.

21 January 2018

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Essential role of LAT in T cell development

21 January 2018

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T cell development in mice lacking all T cell receptor zeta family members (Zeta, eta, and FcepsilonRIgamma).

21 January 2018

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Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene

21 January 2018

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Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+ CD8+ thymocytes

21 January 2018

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Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav.

21 January 2018

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CD3 delta deficiency arrests development of the alpha beta but not the gamma delta T cell lineage

21 January 2018

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Normal B lymphocyte development but impaired T cell maturation in CD45-exon6 protein tyrosine phosphatase-deficient mice

21 January 2018

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CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation

21 January 2018

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Vav regulates peptide-specific apoptosis in thymocytes

21 January 2018

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Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk.

21 January 2018

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Tec family kinases modulate thresholds for thymocyte development and selection

21 January 2018

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Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice

21 January 2018

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RasGRP is essential for mouse thymocyte differentiation and TCR signaling

21 January 2018

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Thymocyte selection is regulated by the helix-loop-helix inhibitor protein, Id3.

21 January 2018

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Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade

21 January 2018

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Selection of the T cell repertoire.

21 January 2018

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Regulation of LMP2 and TAP1 genes by IRF-1 explains the paucity of CD8+ T cells in IRF-1-/- mice.

21 January 2018

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The interferon regulatory transcription factor IRF-1 controls positive and negative selection of CD8+ thymocytes.

21 January 2018

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Bclx regulates the survival of double-positive thymocytes

21 January 2018

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Requirement for RORgamma in thymocyte survival and lymphoid organ development

21 January 2018

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The transcription factor NFAT4 is involved in the generation and survival of T cells

21 January 2018

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Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure

21 January 2018

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The immunological synapse.

21 January 2018

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Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction

21 January 2018

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Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation

21 January 2018

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Antigen receptor-induced activation and cytoskeletal rearrangement are impaired in Wiskott-Aldrich syndrome protein-deficient lymphocytes

21 January 2018

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The vav exchange factor is an essential regulator in actin-dependent receptor translocation to the lymphocyte-antigen-presenting cell interface

21 January 2018

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Three-dimensional segregation of supramolecular activation clusters in T cells

21 January 2018

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Cbl: many adaptations to regulate protein tyrosine kinases

21 January 2018

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Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice

21 January 2018

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Altered thymic positive selection and intracellular signals in Cbl-deficient mice

21 January 2018

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Cbl-b regulates the CD28 dependence of T-cell activation.

21 January 2018

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Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells

21 January 2018

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Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

21 January 2018

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Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

21 January 2018

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Differential T cell costimulatory requirements in CD28-deficient mice

21 January 2018

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Induction of unresponsiveness and impaired T cell expansion by staphylococcal enterotoxin B in CD28-deficient mice

21 January 2018

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T cell activation determined by T cell receptor number and tunable thresholds.

21 January 2018

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Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4

21 January 2018

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Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

21 January 2018

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Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation

21 January 2018

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Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.

21 January 2018

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B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes

21 January 2018

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ICOS is essential for effective T-helper-cell responses

21 January 2018

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ICOS co-stimulatory receptor is essential for T-cell activation and function

21 January 2018

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Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor

21 January 2018

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Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice

21 January 2018

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The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation

21 January 2018

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Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand

21 January 2018

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Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis

21 January 2018

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CD40 ligand-dependent T cell activation: requirement of B7-CD28 signaling through CD40.

21 January 2018

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Ox40-ligand has a critical costimulatory role in dendritic cell:T cell interactions

21 January 2018

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OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL Responses after virus infection

21 January 2018

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Impairment of antigen-presenting cell function in mice lacking expression of OX40 ligand

21 January 2018

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T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

21 January 2018

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Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor

21 January 2018

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Immune responses in interleukin-2-deficient mice

21 January 2018

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PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

21 January 2018

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Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

21 January 2018

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It takes more than two to tango

21 January 2018

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Impaired Fas response and autoimmunity in Pten+/- mice

21 January 2018

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7 January 2021

Regulation of expression of IL-4 alleles: analysis using a chimeric GFP/IL-4 gene

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7 January 2021

Positive and negative thymocyte selection induced by different concentrations of a single peptide

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7 January 2021

MHC Class II Molecules Are Not Required for Survival of Newly Generated CD4+ T Cells, but Affect Their Long-Term Life Span

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7 January 2021

pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells

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7 January 2021

Fyn can partially substitute for Lck in T lymphocyte development

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7 January 2021

Requirement for the SLP-76 adaptor GADS in T cell development

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7 January 2021

T cell development in mice that lack the zeta chain of the T cell antigen receptor complex

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7 January 2021

A Requirement for the Rho-Family GTP Exchange Factor Vav in Positive and Negative Selection of Thymocytes

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7 January 2021

CD3delta couples T-cell receptor signalling to ERK activation and thymocyte positive selection

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7 January 2021

Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice

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7 January 2021

Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta

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7 January 2021

B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation

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7 January 2021

Duration of TCR stimulation determines costimulatory requirement of T cells

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7 January 2021

Distinct roles for LFA-1 and CD28 during activation of naive T cells: adhesion versus costimulation

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7 January 2021

Mice deficient for the CD40 ligand

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7 January 2021

Identifiers

DOI

10.1038/35095551

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3 August 2017

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