(Q28291637)

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TLR signaling

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Europe PubMed Central

TLR signaling (English)

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toll-like receptor

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transforming growth factor beta activated kinase 1 complex

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Gene Ontology release 2020-05-02

Gene Ontology ID

author name string

T Kawai

1

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S Akira

2

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language of work or name

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publication date

May 2006

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Cell Death & Differentiation

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13

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816-25

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5

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The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401850

20 April 2017

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401850

20 April 2017

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401850

20 April 2017

Toll-like receptors in innate immunity

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401850

20 April 2017

Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401850

20 April 2017

Discrimination of bacterial lipoproteins by Toll-like receptor 6

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401850

20 April 2017

The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401850

20 April 2017

Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401850

20 April 2017

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401850

20 April 2017

A toll-like receptor that prevents infection by uropathogenic bacteria

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401850

20 April 2017

Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401850

20 April 2017

Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401850

20 April 2017

Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401850

20 April 2017

Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401850

20 April 2017

Recognition of single-stranded RNA viruses by Toll-like receptor 7

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401850

20 April 2017

Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401850

20 April 2017

A Toll-like receptor recognizes bacterial DNA

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401850

20 April 2017

Toll-like receptor signalling

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401850

20 April 2017

IRAK-M is a negative regulator of Toll-like receptor signaling

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401850

20 April 2017

Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401850

20 April 2017

Pyogenic bacterial infections in humans with IRAK-4 deficiency

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401850

20 April 2017

Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401850

20 April 2017

The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401850

20 April 2017

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401850

20 April 2017

Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401850

20 April 2017

TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401850

20 April 2017

Triggering the interferon antiviral response through an IKK-related pathway

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401850

20 April 2017

IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401850

20 April 2017

IRF-7 is the master regulator of type-I interferon-dependent immune responses

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401850

20 April 2017

Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401850

20 April 2017

Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401850

20 April 2017

The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401850

20 April 2017

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401850

20 April 2017

mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401850

20 April 2017

The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401850

20 April 2017

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401850

20 April 2017

Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401850

20 April 2017

VISA is an adapter protein required for virus-triggered IFN-beta signaling

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401850

20 April 2017

Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401850

20 April 2017

Toll-like receptor control of the adaptive immune responses

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401850

20 April 2017

Toll-like receptors: critical proteins linking innate and acquired immunity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401850

20 April 2017

NF-kappaB: linking inflammation and immunity to cancer development and progression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401850

20 April 2017

AP-1 as a regulator of cell life and death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401850

20 April 2017

Ubiquitin signalling in the NF-kappaB pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401850

20 April 2017

IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401850

20 April 2017

Cell type-specific involvement of RIG-I in antiviral response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401850

20 April 2017

The immune response of Drosophila

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401850

21 January 2018

Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401850

21 January 2018

TLR11 activation of dendritic cells by a protozoan profilin-like protein.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401850

21 January 2018

The Toll‐like receptor 7 (TLR7)‐specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401850

21 January 2018

TLR9-Dependent Recognition of MCMV by IPC and DC Generates Coordinated Cytokine Responses that Activate Antiviral NK Cell Function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401850

21 January 2018

Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401850

21 January 2018

Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401850

21 January 2018

The novel functions of ubiquitination in signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401850

21 January 2018

Essential function for the kinase TAK1 in innate and adaptive immune responses.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401850

21 January 2018

TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401850

21 January 2018

Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401850

21 January 2018

Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401850

21 January 2018

Type I interferons (alpha/beta) in immunity and autoimmunity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401850

21 January 2018

Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401850

21 January 2018

TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401850

21 January 2018

RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401850

21 January 2018

Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401850

21 January 2018

Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3...

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401850

21 January 2018

Cutting edge: TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not toll/IL-1 receptor domain-containing adaptor-inducing IFN-beta (TRIF)-dependent pathway in TLR signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401850

21 January 2018

IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401850

21 January 2018

The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401850

21 January 2018

Differential requirement for TANK-binding kinase-1 in type I interferon responses to toll-like receptor activation and viral infection

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401850

21 January 2018

Plasmacytoid dendritic cells in immunity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401850

21 January 2018

Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401850

21 January 2018

The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401850

21 January 2018

Viral infection and Toll-like receptor agonists induce a differential expression of type I and lambda interferons in human plasmacytoid and monocyte-derived dendritic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401850

21 January 2018

Regulation of IFN regulatory factor-7 and IFN-alpha production by enveloped virus and lipopolysaccharide in human plasmacytoid dendritic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401850

21 January 2018

Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401850

21 January 2018

Toll-like receptor 9 signaling activates NF-kappaB through IFN regulatory factor-8/IFN consensus sequence binding protein in dendritic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401850

21 January 2018

Replication-dependent potent IFN-alpha induction in human plasmacytoid dendritic cells by a single-stranded RNA virus

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401850

21 January 2018

Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401850

21 January 2018

Does Toll-like receptor 3 play a biological role in virus infections?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401850

21 January 2018

TLR-independent induction of dendritic cell maturation and adaptive immunity by negative-strand RNA viruses.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401850

21 January 2018

Overexpression of Helicard, a CARD-containing helicase cleaved during apoptosis, accelerates DNA degradation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401850

21 January 2018

Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401850

21 January 2018

A FADD-dependent innate immune mechanism in mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401850

21 January 2018

Cutting edge: preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401850

7 January 2021

based on heuristic

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A serine/threonine kinase, Cot/Tpl2, modulates bacterial DNA-induced IL-12 production and Th cell differentiation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401850

7 January 2021

based on heuristic

inferred from DOI database lookup

Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401850

7 January 2021

based on heuristic

inferred from DOI database lookup

Recognition of CpG DNA is mediated by signaling pathways dependent on the adaptor protein MyD88

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401850

7 January 2021

based on heuristic

inferred from DOI database lookup

Unresponsiveness of MyD88-deficient mice to endotoxin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401850

7 January 2021

based on heuristic

inferred from DOI database lookup

A CRM1-dependent nuclear export pathway is involved in the regulation of IRF-5 subcellular localization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401850

7 January 2021

based on heuristic

inferred from DOI database lookup

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