(Q39680793)

English

Mutants of Streptomyces clavuligerus with disruptions in different genes for clavulanic acid biosynthesis produce large amounts of holomycin: possible cross-regulation of two unrelated secondary metabolic pathways

scientific article published on December 2002

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Mutants of Streptomyces clavuligerus with disruptions in different genes for clavulanic acid biosynthesis produce large amounts of holomycin: possible cross-regulation of two unrelated secondary metabolic pathways (English)

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

2 references

ChEBI release 2020-05-28

Streptomyces clavuligerus

1 reference

Streptomyces coelicolor

1 reference

Streptomyces flavovirens

1 reference

Streptomyces katsurahamanus

1 reference

Streptomyces griseus

1 reference

Streptomyces flavogriseus

1 reference

Streptomyces albidoflavus

1 reference

Streptomyces jumonjinensis

1 reference

1 reference

1 reference

clavulanic acid

1 reference

N-{4-oxo-5H-[1,2]dithiolo[3,4-b]pyrrol-3-yl}ethanimidic acid

1 reference

(3Z)-7-oxo-3-(2-oxoethylidene)-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

1 reference

author name string

Alvaro de la Fuente

1

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Luis M Lorenzana

2

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Juan F Martín

3

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Paloma Liras

4

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

language of work or name

0 references

publication date

1 December 2002

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

full work available at URL

https://europepmc.org/articles/pmc135446?pdf=render

1 reference

19 March 2024

https://api.unpaywall.org/v2/10.1128/jb.184.23.6559-6565.2002?email=unpaywall_01@example.com

Journal of Bacteriology

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

184

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

23

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

6559-6565

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

online access status

1 reference

19 March 2024

https://api.unpaywall.org/v2/10.1128/jb.184.23.6559-6565.2002?email=unpaywall_01@example.com

access restriction status

1 reference

based on heuristic

inferred from online access status

CcaR is an autoregulatory protein that binds to the ccaR and cefD-cmcI promoters of the cephamycin C-clavulanic acid cluster in Streptomyces clavuligerus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=135446

14 September 2017

Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=135446

14 September 2017

The clavulanic acid biosynthetic cluster of Streptomyces clavuligerus: genetic organization of the region upstream of the car gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=135446

14 September 2017

Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=135446

14 September 2017

Clavulanic acid, a beta-lactamase inhibitor: biosynthesis and molecular genetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=135446

14 September 2017

Expansion of the clavulanic acid gene cluster: identification and in vivo functional analysis of three new genes required for biosynthesis of clavulanic acid by Streptomyces clavuligerus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=135446

14 September 2017

Early cephamycin biosynthetic genes are expressed from a polycistronic transcript in Streptomyces clavuligerus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=135446

14 September 2017

Deletion of the pyc gene blocks clavulanic acid biosynthesis except in glycerol-containing medium: evidence for two different genes in formation of the C3 unit.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=135446

14 September 2017

Genes specific for the biosynthesis of clavam metabolites antipodal to clavulanic acid are clustered with the gene for clavaminate synthase 1 in Streptomyces clavuligerus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=135446

14 September 2017

beta-Lactam synthetase: a new biosynthetic enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=135446

14 September 2017

Chemistry and biosynthesis of clavulanic acid and other clavams

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=135446

14 September 2017

Amy as a reporter gene for promoter activity in Nocardia lactamdurans: comparison of promoters of the cephamycin cluster

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=135446

14 September 2017

A regulatory gene (ccaR) required for cephamycin and clavulanic acid production in Streptomyces clavuligerus: amplification results in overproduction of both beta-lactam compounds

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=135446

14 September 2017

Functional analysis of the gene encoding the clavaminate synthase 2 isoenzyme involved in clavulanic acid biosynthesis in Streptomyces clavuligerus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=135446

14 September 2017

Utilization of ornithine and arginine as specific precursors of clavulanic acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=135446

14 September 2017

Characterization and expression of the arginine biosynthesis gene cluster of Streptomyces clavuligerus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=135446

15 June 2018

A pathway-specific transcriptional activator regulates late steps of clavulanic acid biosynthesis in Streptomyces clavuligerus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=135446

15 June 2018

Holomycin and N-propionylholothin, antibiotics produced by a cephamycin C producer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=135446

15 June 2018

Holomycin and an antibiotic(MM 19290) related to tunicamycin, metabolites of Streptomyces clavuligerus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=135446

15 June 2018

ORF6 from the clavulanic acid gene cluster of Streptomyces clavuligerus has ornithine acetyltransferase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=135446

21 August 2018

The claR gene of Streptomyces clavuligerus, encoding a LysR-type regulatory protein controlling clavulanic acid biosynthesis, is linked to the clavulanate-9-aldehyde reductase (car) gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=135446

21 August 2018

Synthesis of holomycin and derivatives

1 reference

https://pubmed.ncbi.nlm.nih.gov/12426344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dissociation of cephamycin and clavulanic acid biosynthesis in Streptomyces clavuligerus

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1128/JB.184.23.6559-6565.2002

Evidence that the immediate biosynthetic precursor of clavulanic acid is its N-aldehyde analogue

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1128/JB.184.23.6559-6565.2002

Origin of the β-Lactam Carbons in Clavulanic Acid from an Unusual Thiamine Pyrophosphate-Mediated Reaction

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1128/JB.184.23.6559-6565.2002

Identifiers

10.1128/JB.184.23.6559-6565.2002

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

ResearchGate publication ID

0 references

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