(Q39684979)

14 September 2017

Human PRP19 interacts with prolyl-hydroxylase PHD3 and inhibits cell death in hypoxia (English)

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14 September 2017

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Masuhiro Sato

1

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14 September 2017

Miki Sakota

series ordinal

2

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14 September 2017

Koh Nakayama

series ordinal

3

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14 September 2017

language of work or name

English

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publication date

30 June 2010

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Experimental Cell Research

14 September 2017

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14 September 2017

316

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14 September 2017

2871-2882

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14 September 2017

17

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Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

14 September 2017

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.06.018

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.06.018

Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.06.018

Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.06.018

Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.06.018

Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.06.018

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.06.018

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.06.018

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.06.018

Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.06.018

Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.06.018

Mammalian EGLN genes have distinct patterns of mRNA expression and regulation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.06.018

A feedback loop involving the Phd3 prolyl hydroxylase tunes the mammalian hypoxic response in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.06.018

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.06.018

Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.06.018

Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.06.018

Prolyl hydroxylase PHD3 activates oxygen-dependent protein aggregation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.06.018

The novel WD-repeat protein Morg1 acts as a molecular scaffold for hypoxia-inducible factor prolyl hydroxylase 3 (PHD3)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.06.018

Oxygen-dependent ATF-4 stability is mediated by the PHD3 oxygen sensor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.06.018

The HIF prolyl hydroxylase PHD3 is a potential substrate of the TRiC chaperonin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.06.018

Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.06.018

Hypoxia-induced assembly of prolyl hydroxylase PHD3 into complexes: implications for its activity and susceptibility for degradation by the E3 ligase Siah2

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.06.018

SNEV is an evolutionarily conserved splicing factor whose oligomerization is necessary for spliceosome assembly

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.06.018

Structural and functional analysis of essential pre-mRNA splicing factor Prp19p

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.06.018

Induction of SM-20 in PC12 cells leads to increased cytochrome c levels, accumulation of cytochrome c in the cytosol, and caspase-dependent cell death

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.06.018

The PSO4 gene is responsible for an error-prone recombinational DNA repair pathway in Saccharomyces cerevisiae.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.06.018

Role of human Pso4 in mammalian DNA repair and association with terminal deoxynucleotidyl transferase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.06.018

The Prp19/Pso4 core complex undergoes ubiquitylation and structural alterations in response to DNA damage

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.06.018

The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.06.018

PHDs overactivation during chronic hypoxia "desensitizes" HIFalpha and protects cells from necrosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.06.018

PLRG1 is an essential regulator of cell proliferation and apoptosis during vertebrate development and tissue homeostasis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.06.018

Early embryonic lethality of mice lacking the essential protein SNEV

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.06.018

Identification of mouse Prp19p as a lipid droplet-associated protein and its possible involvement in the biogenesis of lipid droplets

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.06.018

10.1016/J.YEXCR.2010.06.018

7 January 2021

Identifiers

DOI

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14 September 2017

1 reference