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English
Transferrin receptor 2 is crucial for iron sensing in human hepatocytes.
scientific article published on 24 June 2010
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scholarly article
1 reference
stated in
Europe PubMed Central
PMC publication ID
2950680
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20576915%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
title
Transferrin receptor 2 is crucial for iron sensing in human hepatocytes
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
2950680
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20576915%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
author
Anil Dhawan
series ordinal
4
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Europe PubMed Central
PMC publication ID
2950680
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20576915%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
Sebastien Farnaud
series ordinal
5
1 reference
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Europe PubMed Central
PMC publication ID
2950680
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20576915%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
Paul Sharp
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7
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Europe PubMed Central
PMC publication ID
2950680
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20576915%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
author name string
Chiara Rapisarda
series ordinal
1
1 reference
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Europe PubMed Central
PMC publication ID
2950680
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20576915%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
Juliana Puppi
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
2950680
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20576915%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
Robin D Hughes
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMC publication ID
2950680
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20576915%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
Robert W Evans
series ordinal
6
1 reference
stated in
Europe PubMed Central
PMC publication ID
2950680
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20576915%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
publication date
24 June 2010
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Europe PubMed Central
PMC publication ID
2950680
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20576915%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
published in
American Journal of Physiology - Gastrointestinal and Liver Physiology
1 reference
stated in
Europe PubMed Central
PMC publication ID
2950680
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20576915%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
volume
299
1 reference
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Europe PubMed Central
PMC publication ID
2950680
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20576915%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
issue
3
1 reference
stated in
Europe PubMed Central
PMC publication ID
2950680
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20576915%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
page(s)
G778-83
1 reference
stated in
Europe PubMed Central
PMC publication ID
2950680
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20576915%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
cites work
Hepatocyte-targeted HFE and TFR2 control hepcidin expression in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950680
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14 September 2017
Cross-talk between the mitogen activated protein kinase and bone morphogenetic protein/hemojuvelin pathways is required for the induction of hepcidin by holotransferrin in primary mouse hepatocytes
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950680
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14 September 2017
Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950680
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14 September 2017
Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950680
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14 September 2017
Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950680
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14 September 2017
Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing
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PubMed Central
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Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload
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14 September 2017
Delayed hepcidin response explains the lag period in iron absorption following a stimulus to increase erythropoiesis.
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PubMed Central
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Regulation of transferrin receptor 2 protein levels by transferrin
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950680
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14 September 2017
IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950680
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14 September 2017
Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis
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PubMed Central
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14 September 2017
Expression of hepcidin in hereditary hemochromatosis: evidence for a regulation in response to the serum transferrin saturation and to non-transferrin-bound iron
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PubMed Central
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14 September 2017
Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950680
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14 September 2017
Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950680
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14 September 2017
The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950680
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14 September 2017
A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950680
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14 September 2017
Hepcidin, a urinary antimicrobial peptide synthesized in the liver
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950680
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14 September 2017
LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950680
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14 September 2017
Huh-7: a human "hemochromatotic" cell line.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950680
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14 September 2017
The role of transferrin receptor 1 and 2 in transferrin-bound iron uptake in human hepatoma cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950680
retrieved
14 September 2017
The Cytoplasmic domain of transferrin receptor 2 dictates its stability and response to holo-transferrin in Hep3B cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950680
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14 September 2017
Diferric transferrin regulates transferrin receptor 2 protein stability
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950680
retrieved
14 September 2017
C/EBPalpha regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism. Cross-talk between C/EBP pathway and iron metabolism
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950680
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15 June 2018
Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950680
retrieved
20 August 2018
Hepcidin is decreased in TFR2 hemochromatosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950680
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20 August 2018
Human Hepatocyte Isolation and Relationship of Cell Viability to Early Graft Function
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950680
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20 August 2018
Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950680
retrieved
20 August 2018
Blunted hepcidin response to oral iron challenge in HFE-related hemochromatosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950680
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1 October 2018
Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20576915
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Decreased liver hepcidin expression in the Hfe knockout mouse
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20576915
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The effects of cryopreservation on human hepatocytes obtained from different sources of liver tissue
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20576915
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1152/AJPGI.00157.2010
1 reference
stated in
Europe PubMed Central
PMC publication ID
2950680
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20576915%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
PMC publication ID
2950680
1 reference
stated in
Europe PubMed Central
PMC publication ID
2950680
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20576915%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
PubMed publication ID
20576915
1 reference
stated in
Europe PubMed Central
PMC publication ID
2950680
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20576915%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
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