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Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload.
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1 reference
stated in
Europe PubMed Central
PubMed ID
19824072
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19824072%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 February 2020
title
Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
19824072
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19824072%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 February 2020
author
Daniel F. Wallace
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
19824072
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19824072%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 February 2020
David M. Frazer
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4
1 reference
stated in
Europe PubMed Central
PubMed ID
19824072
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19824072%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 February 2020
Gregory J Anderson
series ordinal
5
1 reference
stated in
Europe PubMed Central
PubMed ID
19824072
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19824072%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 February 2020
Nathan V Subramaniam
series ordinal
6
1 reference
stated in
Europe PubMed Central
PubMed ID
19824072
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19824072%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 February 2020
Lesa Summerville
series ordinal
2
object named as
Lesa Summerville
1 reference
stated in
Europe PubMed Central
PubMed ID
19824072
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19824072%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 February 2020
Emily M Crampton
series ordinal
3
object named as
Emily M Crampton
1 reference
stated in
Europe PubMed Central
PubMed ID
19824072
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19824072%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 February 2020
language of work or name
English
0 references
publication date
1 December 2009
1 reference
stated in
Europe PubMed Central
PubMed ID
19824072
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19824072%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 February 2020
published in
Hepatology
1 reference
stated in
Europe PubMed Central
PubMed ID
19824072
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19824072%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 February 2020
volume
50
1 reference
stated in
Europe PubMed Central
PubMed ID
19824072
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19824072%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 February 2020
issue
6
1 reference
stated in
Europe PubMed Central
PubMed ID
19824072
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19824072%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 February 2020
page(s)
1992-2000
1 reference
stated in
Europe PubMed Central
PubMed ID
19824072
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19824072%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 February 2020
cites work
Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23198
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23198
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23198
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23198
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23198
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Early onset hereditary hemochromatosis resulting from a novel TFR2 gene nonsense mutation (R105X) in two siblings of north French descent
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23198
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
New TFR2 mutations in young Italian patients with hemochromatosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23198
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23198
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hepcidin is decreased in TFR2 hemochromatosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23198
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of hepcidin is down-regulated in TfR2 mutant mice manifesting a phenotype of hereditary hemochromatosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23198
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23198
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hfe acts in hepatocytes to prevent hemochromatosis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23198
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Targeted disruption of the hepatic transferrin receptor 2 gene in mice leads to iron overload.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23198
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Juvenile hemochromatosis associated with pathogenic mutations of adult hemochromatosis genes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23198
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inactivation of the murine Transferrin Receptor 2 gene using the Cre recombinase: loxP system.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23198
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: increased duodenal expression of the iron transporter DMT1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23198
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Prohepcidin localises to the Golgi compartment and secretory pathway in hepatocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23198
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of transferrin receptor 2 protein levels by transferrin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23198
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Strain and gender modulate hepatic hepcidin 1 and 2 mRNA expression in mice.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23198
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mouse strain differences determine severity of iron accumulation in Hfe knockout model of hereditary hemochromatosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23198
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Decreased liver hepcidin expression in the Hfe knockout mouse
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23198
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Iron stores modulate hepatic hepcidin expression by an HFE-independent pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23198
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Distinct requirements for Hfe in basal and induced hepcidin levels in iron overload and inflammation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23198
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Blunted hepcidin response to oral iron challenge in HFE-related hemochromatosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23198
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
STAT3 is required for IL-6-gp130-dependent activation of hepcidin in vivo.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23198
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23198
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TfR2 localizes in lipid raft domains and is released in exosomes to activate signal transduction along the MAPK pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23198
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23198
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Association of the transferrin receptor in human placenta with HFE, the protein defective in hereditary hemochromatosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23198
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23198
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Cytoplasmic domain of transferrin receptor 2 dictates its stability and response to holo-transferrin in Hep3B cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23198
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23198
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23198
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23198
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23198
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cross-talk between the mitogen activated protein kinase and bone morphogenetic protein/hemojuvelin pathways is required for the induction of hepcidin by holotransferrin in primary mouse hepatocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23198
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1002/HEP.23198
1 reference
stated in
Europe PubMed Central
PubMed ID
19824072
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19824072%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 February 2020
PubMed ID
19824072
1 reference
stated in
Europe PubMed Central
PubMed ID
19824072
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19824072%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 February 2020
ResearchGate publication ID
26889708
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