(Q39691943)

14 September 2017

L-3-n-butylphthalide improves cognitive impairment and reduces amyloid-beta in a transgenic model of Alzheimer's disease (English)

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14 September 2017

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cognitive dysfunction

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Ying Peng

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6634596&resulttype=core&format=json

15 May 2020

Jing Sun

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6634596&resulttype=core&format=json

15 May 2020

Stephanie Hon

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6634596&resulttype=core&format=json

15 May 2020

Alyssa N Nylander

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6634596&resulttype=core&format=json

15 May 2020

Weiming Xia

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6634596&resulttype=core&format=json

15 May 2020

Yipu Feng

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6634596&resulttype=core&format=json

15 May 2020

Xiaoliang Wang

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6634596&resulttype=core&format=json

15 May 2020

Cynthia A Lemere

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6634596&resulttype=core&format=json

15 May 2020

language of work or name

English

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publication date

1 June 2010

1 reference

14 September 2017

Journal of Neuroscience

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6634596&resulttype=core&format=json

15 May 2020

volume

30

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6634596&resulttype=core&format=json

15 May 2020

issue

24

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6634596&resulttype=core&format=json

15 May 2020

page(s)

8180-8189

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6634596&resulttype=core&format=json

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

15 May 2020

cites work

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12 December 2020

Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network

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12 December 2020

An overview of methods for assessment of free radical activity in biology

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12 December 2020

Regulation of APP cleavage by alpha-, beta- and gamma-secretases

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12 December 2020

A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer's disease

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12 December 2020

Alzheimer's disease: genes, proteins, and therapy

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12 December 2020

Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer's disease.

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12 December 2020

Inhibitory effects of chiral 3-n-butylphthalide on inflammation following focal ischemic brain injury in rats.

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12 December 2020

Constitutive shedding of the amyloid precursor protein ectodomain is up-regulated by tumour necrosis factor-alpha converting enzyme

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12 December 2020

Oxidative damage is the earliest event in Alzheimer disease

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12 December 2020

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

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12 December 2020

Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo

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12 December 2020

Beta-secretase cleavage at amino acid residue 34 in the amyloid beta peptide is dependent upon gamma-secretase activity

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12 December 2020

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

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12 December 2020

Effects of chiral 3-n-butylphthalide on apoptosis induced by transient focal cerebral ischemia in rats.

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12 December 2020

Effects of NBP on ATPase and anti-oxidant enzymes activities and lipid peroxidation in transient focal cerebral ischemic rats

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12 December 2020

Amyloid beta-peptide is produced by cultured cells during normal metabolism

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12 December 2020

Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors

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12 December 2020

Production of the Alzheimer amyloid beta protein by normal proteolytic processing

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12 December 2020

ADAMs family members as amyloid precursor protein alpha-secretases

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12 December 2020

Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease.

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12 December 2020

Stimulation of beta-amyloid precursor protein alpha-processing by phorbol ester involves calcium and calpain activation

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12 December 2020

Antiplatelet and antithrombotic activity of L-3-n-butylphthalide in rats

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12 December 2020

Therapeutic effects of PKC activators in Alzheimer's disease transgenic mice

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12 December 2020

Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice

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12 December 2020

Lipopolysaccharide stimulates the secretion of the amyloid precursor protein via a protein kinase C-mediated pathway.

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12 December 2020

Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice

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12 December 2020

Inflammation and neurodegenerative diseases

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12 December 2020

A specific amyloid-beta protein assembly in the brain impairs memory

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12 December 2020

Effects of huperzine A on amyloid precursor protein processing and beta-amyloid generation in human embryonic kidney 293 APP Swedish mutant cells

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12 December 2020

Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing

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12 December 2020

l-3-n-Butylphthalide improves cognitive impairment induced by chronic cerebral hypoperfusion in rats

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12 December 2020

Production, purification and functional validation of human secreted amyloid precursor proteins for use as neuropharmacological reagents

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12 December 2020

Huperzine A regulates amyloid precursor protein processing via protein kinase C and mitogen-activated protein kinase pathways in neuroblastoma SK-N-SH cells over-expressing wild type human amyloid precursor protein 695.

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12 December 2020

l-3-n-Butylphthalide ameliorates beta-amyloid-induced neuronal toxicity in cultured neuronal cells

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12 December 2020

Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease.

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12 December 2020

Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model.

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12 December 2020

Complement C3 deficiency leads to accelerated amyloid beta plaque deposition and neurodegeneration and modulation of the microglia/macrophage phenotype in amyloid precursor protein transgenic mice

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12 December 2020

Neuroprotective secreted amyloid precursor protein acts by disrupting amyloid precursor protein dimers

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12 December 2020

L-3-n-butylphthalide improves cognitive impairment induced by intracerebroventricular infusion of amyloid-beta peptide in rats

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12 December 2020

Cleavage of amyloid beta peptide during constitutive processing of its precursor

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12 December 2020

Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease.

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12 December 2020

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

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12 December 2020

Developments of a water-maze procedure for studying spatial learning in the rat

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12 December 2020

Processing of the beta-amyloid precursor protein and its regulation in Alzheimer's disease

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12 December 2020

Conventional protein kinase C (PKC)-alpha and novel PKC epsilon, but not -delta, increase the secretion of an N-terminal fragment of Alzheimer's disease amyloid precursor protein from PKC cDNA transfected 3Y1 fibroblasts

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12 December 2020

Secreted forms of beta-amyloid precursor protein protect against ischemic brain injury

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12 December 2020

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein.

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12 December 2020

Normal and abnormal biology of the beta-amyloid precursor protein

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12 December 2020

Activation of protein kinase C inhibits cellular production of the amyloid beta-protein

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12 December 2020

Selective ectodomain phosphorylation and regulated cleavage of beta-amyloid precursor protein

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12 December 2020

Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide

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12 December 2020

Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease

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12 December 2020

Phorbol esters affect multiple steps in beta-amyloid precursor protein trafficking and amyloid beta-protein production

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12 December 2020

Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives

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12 December 2020

Amyloid precursor protein potentiates the neurotrophic activity of NGF.

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12 December 2020

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

1 reference

12 December 2020

10.1523/JNEUROSCI.0340-10.2010

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6634596&resulttype=core&format=json

15 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6634596&resulttype=core&format=json

15 May 2020

1 reference