(Q39695436)

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Novel monocyclam derivatives as HIV entry inhibitors: Design, synthesis, anti-HIV evaluation, and their interaction with the CXCR4 co-receptor.

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scholarly article

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5 February 2020

Novel monocyclam derivatives as HIV entry inhibitors: Design, synthesis, anti-HIV evaluation, and their interaction with the CXCR4 co-receptor (English)

1 reference

Europe PubMed Central

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5 February 2020

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Violeta I Pérez-Nueno

2

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5 February 2020

5

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5 February 2020

José I Borrell

6

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5 February 2020

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5 February 2020

Bonaventura Clotet Sala

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object named as

Bonaventura Clotet

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5 February 2020

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Sofia Pettersson

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5 February 2020

Maria Pau Mena

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5 February 2020

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1 August 2010

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5 February 2020

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5 February 2020

5

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5 February 2020

1272-1281

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5 February 2020

8

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5 February 2020

HIV entry inhibitors.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000124

7 January 2021

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HIV-1 integrase: a target for new AIDS chemotherapeutics

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Recent advances in understanding the molecular mechanisms of HIV-1 entry and fusion: revisiting current targets and considering new options for therapeutic intervention

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7 January 2021

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Current status and challenges of antiretroviral research and therapy

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7 January 2021

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Emerging anti-HIV drugs

1 reference

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7 January 2021

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The bicyclams, a new class of potent human immunodeficiency virus inhibitors, block viral entry after binding

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000124

7 January 2021

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Bicyclams, a class of potent anti-HIV agents, are targeted at the HIV coreceptor fusin/CXCR-4.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000124

7 January 2021

based on heuristic

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Activity of different bicyclam derivatives against human immunodeficiency virus depends on their interaction with the CXCR4 chemokine receptor

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000124

7 January 2021

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AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000124

7 January 2021

based on heuristic

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Inhibition of human immunodeficiency virus replication by a dual CCR5/CXCR4 antagonist

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000124

7 January 2021

based on heuristic

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Multiple-dose escalation study of the safety, pharmacokinetics, and biologic activity of oral AMD070, a selective CXCR4 receptor inhibitor, in human subjects

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000124

7 January 2021

based on heuristic

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Molecular mechanism of action of monocyclam versus bicyclam non-peptide antagonists in the CXCR4 chemokine receptor

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000124

7 January 2021

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Discovery of novel non-cyclam polynitrogenated CXCR4 coreceptor inhibitors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000124

7 January 2021

based on heuristic

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Discovery of novel HIV entry inhibitors for the CXCR4 receptor by prospective virtual screening.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000124

7 January 2021

based on heuristic

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Design and synthesis of zinc-selective chelators for extracellular applications

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000124

7 January 2021

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Molecular interactions of cyclam and bicyclam non-peptide antagonists with the CXCR4 chemokine receptor

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000124

7 January 2021

based on heuristic

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A point mutation that confers constitutive activity to CXCR4 reveals that T140 is an inverse agonist and that AMD3100 and ALX40-4C are weak partial agonists

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000124

7 January 2021

based on heuristic

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Identification of residues of CXCR4 critical for human immunodeficiency virus coreceptor and chemokine receptor activities

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000124

7 January 2021

based on heuristic

inferred from DOI database lookup

AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000124

7 January 2021

based on heuristic

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Mutation of Asp(171) and Asp(262) of the chemokine receptor CXCR4 impairs its coreceptor function for human immunodeficiency virus-1 entry and abrogates the antagonistic activity of AMD3100.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000124

7 January 2021

based on heuristic

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Mutations at the CXCR4 interaction sites for AMD3100 influence anti-CXCR4 antibody binding and HIV-1 entry

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000124

7 January 2021

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Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000124

7 January 2021

based on heuristic

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Molecular mechanism of AMD3100 antagonism in the CXCR4 receptor: transfer of binding site to the CXCR3 receptor

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000124

7 January 2021

based on heuristic

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Comparison of the potential multiple binding modes of bicyclam, monocylam, and noncyclam small-molecule CXC chemokine receptor 4 inhibitors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000124

7 January 2021

based on heuristic

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Comparative protein modelling by satisfaction of spatial restraints

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000124

7 January 2021

based on heuristic

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Small-molecule antagonists of CCR5 and CXCR4: a promising new class of anti-HIV-1 drugs

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000124

7 January 2021

based on heuristic

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Comparison of ligand-based and receptor-based virtual screening of HIV entry inhibitors for the CXCR4 and CCR5 receptors using 3D ligand shape matching and ligand-receptor docking

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000124

7 January 2021

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Iterative partial equalization of orbital electronegativity—a rapid access to atomic charges

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000124

7 January 2021

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Protein-based virtual screening of chemical databases. 1. Evaluation of different docking/scoring combinations.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000124

7 January 2021

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Comparative analysis of putative agonist-binding modes in the human A1 adenosine receptor

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000124

7 January 2021

based on heuristic

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Molecular dynamics simulations on SDF-1alpha: binding with CXCR4 receptor

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000124

7 January 2021

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Development and testing of a general amber force field

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7 January 2021

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A point-charge force field for molecular mechanics simulations of proteins based on condensed-phase quantum mechanical calculations

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7 January 2021

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Numerical integration of the cartesian equations of motion of a system with constraints: molecular dynamics of n-alkanes

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7 January 2021

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HIV-1 escape to CCR5 coreceptor antagonism through selection of CXCR4-using variants in vitro

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000124

7 January 2021

based on heuristic

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Anti-HIV activity and resistance profile of the CXC chemokine receptor 4 antagonist POL3026.

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7 January 2021

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Cell adhesion through alphaV-containing integrins is required for efficient HIV-1 infection in macrophages

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7 January 2021

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Synthesis and structure-activity relationships of azamacrocyclic C-X-C chemokine receptor 4 antagonists: analogues containing a single azamacrocyclic ring are potent inhibitors of T-cell tropic (X4) HIV-1 replication

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Comparative evaluation of 11 scoring functions for molecular docking

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