(Q39695658)

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Targeting the receptor tyrosine kinase RET sensitizes breast cancer cells to tamoxifen treatment and reveals a role for RET in endocrine resistance.

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5 February 2020

Targeting the receptor tyrosine kinase RET sensitizes breast cancer cells to tamoxifen treatment and reveals a role for RET in endocrine resistance (English)

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5 February 2020

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5 February 2020

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5 February 2020

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I Plaza-Menacho

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5 February 2020

D Robertson

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5 February 2020

S Drury

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5 February 2020

M Dowsett

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5 February 2020

L-A Martin

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7 June 2010

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5 February 2020

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5 February 2020

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5 February 2020

4648-4657

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5 February 2020

https://scigraph.springernature.com/pub.10.1038/onc.2010.209

0 references

pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.209

21 January 2018

p90 ribosomal S6 kinase and p70 ribosomal S6 kinase link phosphorylation of the eukaryotic chaperonin containing TCP-1 to growth factor, insulin, and nutrient signaling

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.209

31 March 2020

Estrogen receptor alpha in human breast cancer: occurrence and significance

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.209

31 March 2020

Endocrine-responsive breast cancer and strategies for combating resistance

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.209

31 March 2020

Treatment of human epidermal growth factor receptor 2-overexpressing breast cancer xenografts with multiagent HER-targeted therapy

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.209

31 March 2020

Crosstalk between the estrogen receptor and the HER tyrosine kinase receptor family: molecular mechanism and clinical implications for endocrine therapy resistance

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.209

31 March 2020

Estrogen-dependent, tamoxifen-resistant tumorigenic growth of MCF-7 cells transfected with HER2/neu

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.209

31 March 2020

Estrogen receptor-alpha hinge-region lysines 302 and 303 regulate receptor degradation by the proteasome

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.209

31 March 2020

The Ret receptor tyrosine kinase pathway functionally interacts with the ERalpha pathway in breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.209

31 March 2020

Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.209

31 March 2020

Rapamycin inhibits proliferation of estrogen-receptor-positive breast cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.209

31 March 2020

Activation of mitogen-activated protein kinase in estrogen receptor alpha-positive breast cancer cells in vitro induces an in vivo molecular phenotype of estrogen receptor alpha-negative human breast tumors

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.209

31 March 2020

Inhibition of mTOR activity restores tamoxifen response in breast cancer cells with aberrant Akt Activity.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.209

31 March 2020

Benefit from adjuvant tamoxifen therapy in primary breast cancer patients according oestrogen receptor, progesterone receptor, EGF receptor and HER2 status

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.209

31 March 2020

A role for glial cell derived neurotrophic factor induced expression by inflammatory cytokines and RET/GFR alpha 1 receptor up-regulation in breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.209

31 March 2020

Profiling of estrogen up- and down-regulated gene expression in human breast cancer cells: insights into gene networks and pathways underlying estrogenic control of proliferation and cell phenotype

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.209

31 March 2020

Phosphorylation of ERK1/2 mitogen-activated protein kinase is associated with poor response to anti-hormonal therapy and decreased patient survival in clinical breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.209

31 March 2020

Oestrogen-receptor-mediated transcription and the influence of co-factors and chromatin state.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.209

31 March 2020

Molecular changes in tamoxifen-resistant breast cancer: relationship between estrogen receptor, HER-2, and p38 mitogen-activated protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.209

31 March 2020

Endocrinology and hormone therapy in breast cancer: aromatase inhibitors versus antioestrogens

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.209

31 March 2020

Identification of CDK10 as an important determinant of resistance to endocrine therapy for breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.209

31 March 2020

Estradiol-induced phosphorylation of serine 118 in the estrogen receptor is independent of p42/p44 mitogen-activated protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.209

31 March 2020

Enhancing the efficacy of hormonal agents with selected targeted agents

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.209

31 March 2020

Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.209

31 March 2020

Estrogen receptor-alpha phosphorylation at serine-118 and tamoxifen response in breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.209

31 March 2020

Lapatinib restores hormone sensitivity with differential effects on estrogen receptor signaling in cell models of human epidermal growth factor receptor 2-negative breast cancer with acquired endocrine resistance

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.209

31 March 2020

Whole-genome cartography of estrogen receptor alpha binding sites

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.209

31 March 2020

Enhanced estrogen receptor (ER) alpha, ERBB2, and MAPK signal transduction pathways operate during the adaptation of MCF-7 cells to long term estrogen deprivation

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.209

31 March 2020

Tamoxifen resistance in breast tumors is driven by growth factor receptor signaling with repression of classic estrogen receptor genomic function

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.209

31 March 2020

Resistance to endocrine therapy in breast cancer: exploiting estrogen receptor/growth factor signaling crosstalk

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.209

31 March 2020

Biological determinants of endocrine resistance in breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.209

31 March 2020

Modulation of epidermal growth factor receptor in endocrine-resistant, oestrogen receptor-positive breast cancer.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.209

31 March 2020

Involvement of steroid hormone and growth factor cross-talk in endocrine response in breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.209

31 March 2020

ERBB2 influences the subcellular localization of the estrogen receptor in tamoxifen-resistant MCF-7 cells leading to the activation of AKT and RPS6KA2.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.209

31 March 2020

Activation of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patients

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.209

31 March 2020

RET-familial medullary thyroid carcinoma mutants Y791F and S891A activate a Src/JAK/STAT3 pathway, independent of glial cell line-derived neurotrophic factor.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.209

31 March 2020

Sorafenib functions to potently suppress RET tyrosine kinase activity by direct enzymatic inhibition and promoting RET lysosomal degradation independent of proteasomal targeting.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.209

31 March 2020

Ras/ERK1/2-mediated STAT3 Ser727 phosphorylation by familial medullary thyroid carcinoma-associated RET mutants induces full activation of STAT3 and is required for c-fos promoter activation, cell mitogenicity, and transformation.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.209

31 March 2020

Distribution and significance of nerve growth factor receptor (NGFR/p75NTR) in normal, benign and malignant breast tissue

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.209

31 March 2020

Potentiation of human estrogen receptor alpha transcriptional activation through phosphorylation of serines 104 and 106 by the cyclin A-CDK2 complex

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.209

31 March 2020

RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.209

31 March 2020

Stopping treatment can reverse acquired resistance to letrozole

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.209

31 March 2020

Caveolin 1 is overexpressed and amplified in a subset of basal-like and metaplastic breast carcinomas: a morphologic, ultrastructural, immunohistochemical, and in situ hybridization analysis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.209

31 March 2020

The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.209

31 March 2020

Mechanisms of tamoxifen resistance: increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.209

31 March 2020

Low phosphorylation of estrogen receptor alpha (ERalpha) serine 118 and high phosphorylation of ERalpha serine 167 improve survival in ER-positive breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.209

31 March 2020

S6 kinase 1 regulates estrogen receptor alpha in control of breast cancer cell proliferation

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.209

31 March 2020

Activation of the MAPK pathway enhances sensitivity of MCF-7 breast cancer cells to the mitogenic effect of estradiol

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.209

31 March 2020

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