(Q39696733)

English

Q39, a quinoxaline 1,4-Di-N-oxide derivative, inhibits hypoxia-inducible factor-1α expression and the Akt/mTOR/4E-BP1 signaling pathway in human hepatoma cells

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scholarly article

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Europe PubMed Central

PubMed publication ID

14 September 2017

Q39, a quinoxaline 1,4-Di-N-oxide derivative, inhibits hypoxia-inducible factor-1α expression and the Akt/mTOR/4E-BP1 signaling pathway in human hepatoma cells (English)

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

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hepatocellular carcinoma

1 reference

based on heuristic

inferred from title

author name string

Qinjie Weng

1

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

Jun Zhang

2

1 reference

Europe PubMed Central

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14 September 2017

Ji Cao

3

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Europe PubMed Central

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14 September 2017

Qing Xia

4

1 reference

Europe PubMed Central

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14 September 2017

Duoduo Wang

5

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Europe PubMed Central

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14 September 2017

Yongzhou Hu

6

1 reference

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14 September 2017

Rong Sheng

7

1 reference

Europe PubMed Central

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14 September 2017

Honghai Wu

8

1 reference

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14 September 2017

Difeng Zhu

9

1 reference

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14 September 2017

Hong Zhu

10

1 reference

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14 September 2017

Qiaojun He

11

1 reference

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14 September 2017

Bo Yang

12

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14 September 2017

publication date

5 June 2010

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14 September 2017

Investigational New Drugs

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14 September 2017

29

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14 September 2017

6

1 reference

Europe PubMed Central

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14 September 2017

1177-1187

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

https://scigraph.springernature.com/pub.10.1007/s10637-010-9462-y

0 references

Q39, a novel synthetic Quinoxaline 1,4-Di-N-oxide compound with anti-cancer activity in hypoxia

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9462-Y

21 January 2018

HIF-1 and tumor progression: pathophysiology and therapeutics

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9462-Y

21 January 2018

Regulation of angiogenesis by hypoxia: role of the HIF system

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9462-Y

21 January 2018

PI3K/PTEN/AKT signaling regulates prostate tumor angiogenesis

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9462-Y

21 January 2018

Vascular endothelial growth factor-mediated autocrine stimulation of prostate tumor cells coincides with progression to a malignant phenotype

1 reference

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21 January 2018

Benzo[a]pyrene-3,6-dione inhibited VEGF expression through inducing HIF-1alpha degradation

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9462-Y

21 January 2018

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9462-Y

21 January 2018

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9462-Y

21 January 2018

HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9462-Y

21 January 2018

Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9462-Y

21 January 2018

Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9462-Y

21 January 2018

Phosphorylation of the eukaryotic translation initiation factor eIF4E contributes to its transformation and mRNA transport activities

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9462-Y

21 January 2018

Hypoxia inducible factor-1: a novel target for cancer therapy

1 reference

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21 January 2018

Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways.

1 reference

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21 January 2018

Inhibition of mitochondrial respiration by the anticancer agent 2-methoxyestradiol.

1 reference

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21 January 2018

Bioreductive drugs: from concept to clinic

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9462-Y

21 January 2018

Overexpression of VEGF and angiopoietin 2: a key to high vascularity of hepatocellular carcinoma?

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9462-Y

21 January 2018

Kallikrein-binding protein suppresses growth of hepatocellular carcinoma by anti-angiogenic activity

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9462-Y

21 January 2018

A quassinoid 6alpha-tigloyloxychaparrinone inhibits hypoxia-inducible factor-1 pathway by inhibition of eukaryotic translation initiation factor 4E phosphorylation

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9462-Y

21 January 2018

MFTZ-1 reduces constitutive and inducible HIF-1α accumulation and VEGF secretion independent of its topoisomerase II inhibition.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20524035

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia inducible factor-1alpha as a cancer drug target

1 reference

https://pubmed.ncbi.nlm.nih.gov/20524035

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antiangiogenic hypoxic cytotoxin TX-402 inhibits hypoxia-inducible factor 1 signaling pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20524035

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A potential autocrine role for vascular endothelial growth factor in prostate cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20524035

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics

1 reference

https://pubmed.ncbi.nlm.nih.gov/20524035

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pseudolaric acid B inhibits angiogenesis and reduces hypoxia-inducible factor 1alpha by promoting proteasome-mediated degradation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20524035

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Significance of vascular endothelial growth factor mRNA expression in invasion and metastasis of hepatocellular carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/20524035

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative correlation of serum levels and tumor expression of vascular endothelial growth factor in patients with hepatocellular carcinoma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20524035

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and cytotoxic activity of 3-phenyl-2-thio-quinoxaline 1,4-dioxide derivatives in hypoxia and in normoxia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20524035

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chrysin inhibits expression of hypoxia-inducible factor-1 through reducing hypoxia-inducible factor-1 stability and inhibiting its protein synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20524035

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vascular endothelial growth factor tightly regulates in vivo development of murine hepatocellular carcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20524035

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S10637-010-9462-Y

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

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