(Q39714708)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20392944%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

title

Cdk5 suppresses the neuronal cell cycle by disrupting the E2F1-DP1 complex (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20392944%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

author

Gabriella D'Arcangelo

5

1 reference

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31 January 2020

author name string

Jie Zhang

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20392944%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Huifang Li

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20392944%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Odessa Yabut

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20392944%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Haley Fitzpatrick

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20392944%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Karl Herrup

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20392944%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

language of work or name

English

0 references

publication date

1 April 2010

1 reference

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31 January 2020

published in

Journal of Neuroscience

1 reference

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31 January 2020

volume

30

1 reference

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31 January 2020

issue

15

1 reference

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31 January 2020

page(s)

5219-5228

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20392944%20AND%20SRC:MED&resulttype=core&format=json

Deregulation of HDAC1 by p25/Cdk5 in neurotoxicity

31 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862267

Hyperphosphorylation of microtubule-associated protein tau: a promising therapeutic target for Alzheimer disease

14 September 2017

1 reference

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Nuclear localization of Cdk5 is a key determinant in the postmitotic state of neurons

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862267

Alternative roles for Cdk5 in learning and synaptic plasticity

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862267

The roles of cyclin-dependent kinase 5 in dendrite and synapse development

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862267

Cell cycle regulation in the postmitotic neuron: oxymoron or new biology?

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862267

The role of CDK5/P25 formation/inhibition in neurodegeneration

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862267

Visualization of molecular interactions by fluorescence complementation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862267

Cyclin-dependent kinase 5 is essential for neuronal cell cycle arrest and differentiation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862267

Identification and characterization of novel isoforms of human DP-1: DP-1{alpha} regulates the transcriptional activity of E2F1 as well as cell cycle progression in a dominant-negative manner

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862267

A Jekyll and Hyde kinase: roles for Cdk5 in brain development and disease

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862267

Simultaneous visualization of multiple protein interactions in living cells using multicolor fluorescence complementation analysis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862267

Cdk5-Mediated Inhibition of the Protective Effects of Transcription Factor MEF2 in Neurotoxicity-Induced Apoptosis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862267

Visualization of interactions among bZIP and Rel family proteins in living cells using bimolecular fluorescence complementation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862267

Sibling rivalry in the E2F family

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862267

E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862267

The protein SET binds the neuronal Cdk5 activator p35nck5a and modulates Cdk5/p35nck5a activity

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862267

Structure and regulation of the CDK5-p25(nck5a) complex

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862267

Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862267

Cyclin A is destroyed in prometaphase and can delay chromosome alignment and anaphase

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862267

E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862267

Genetic evidence for the interactions of cyclin D1 and p27(Kip1) in mice

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862267

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862267

Cyclin-dependent kinase 5-deficient mice demonstrate novel developmental arrest in cerebral cortex

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862267

Cyclin-dependent kinases: engines, clocks, and microprocessors

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862267

Cyclin D2 interacts with cdk-5 and modulates cellular cdk-5/p35 activity

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862267

Cyclin-dependent kinase 5 is associated with apoptotic cell death during development and tissue remodeling

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862267

The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862267

Distinct roles for cyclin-dependent kinases in cell cycle control

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862267

Functional synergy between DP-1 and E2F-1 in the cell cycle-regulating transcription factor DRTF1/E2F.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862267

p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862267

Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862267

Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862267

A family of human cdc2-related protein kinases

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862267

Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862267

D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862267

Cyclin D1 induction of cellular migration requires p27(KIP1).

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862267

Retinoic acid promotes ubiquitination and proteolysis of cyclin D1 during induced tumor cell differentiation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862267

Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's disease.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862267

Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862267

Suppression of mutant Huntingtin aggregate formation by Cdk5/p35 through the effect on microtubule stability.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862267

Mouse development and cell proliferation in the absence of D-cyclins.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862267

Degradation of p27(Kip1) at the G(0)-G(1) transition mediated by a Skp2-independent ubiquitination pathway

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862267

p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment

20 August 2018

1 reference

12 December 2020

Efficient gene transfer into the embryonic mouse brain using in vivo electroporation

1 reference

12 December 2020

Role of serine 10 phosphorylation in p27 stabilization revealed by analysis of p27 knock-in mice harboring a serine 10 mutation

1 reference

12 December 2020

Ectopic cell cycle events link human Alzheimer's disease and amyloid precursor protein transgenic mouse models

1 reference

12 December 2020

Identification of nuclear import mechanisms for the neuronal Cdk5 activator

1 reference

12 December 2020

Cyclin D2 translocates p27 out of the nucleus and promotes its degradation at the G0-G1 transition

1 reference

12 December 2020

E2F1 works as a cell cycle suppressor in mature neurons

1 reference

12 December 2020

The brain-specific activator p35 allows Cdk5 to escape inhibition by p27Kip1 in neurons.

1 reference

12 December 2020

E2F-1 functions in mice to promote apoptosis and suppress proliferation

1 reference

12 December 2020

The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity

1 reference

12 December 2020

10.1523/JNEUROSCI.5628-09.2010

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20392944%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20392944%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

PubMed publication ID

20392944

1 reference