(Q39714953)

14 September 2017

title

Identification of tri- and tetracyclic pyrimidinediones as sirtuin inhibitors (English)

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9

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11

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Angela Nebbioso

7

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Dante Rotili

Dante Rotili

1

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Lucia Altucci

Lucia Altucci

13

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Antonello Mai

Antonello Mai

14

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Vincenzo Carafa

Vincenzo Carafa

3

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Domenico Tarantino

2

Domenico Tarantino

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14 September 2017

4

Ester Lara

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8

Jörg Schemies

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10

Aleksey G Kazantsev

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12

Mario F Fraga

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14 September 2017

Sarah Meade

5

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Giorgia Botta

6

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14 September 2017

publication date

1 May 2010

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14 September 2017

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14 September 2017

volume

5

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14 September 2017

issue

5

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14 September 2017

page(s)

674-677

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The Sir 2 family of protein deacetylases

14 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000030

Sirtuins in mammals: insights into their biological function

21 January 2018

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https://api.crossref.org/works/10.1002%2FCMDC.201000030

Biological and potential therapeutic roles of sirtuin deacetylases

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https://api.crossref.org/works/10.1002%2FCMDC.201000030

The Sirtuin family: therapeutic targets to treat diseases of aging

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https://api.crossref.org/works/10.1002%2FCMDC.201000030

Sirtuins--novel therapeutic targets to treat age-associated diseases

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https://api.crossref.org/works/10.1002%2FCMDC.201000030

SIRTUIN 1: regulating the regulator

21 January 2018

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https://api.crossref.org/works/10.1002%2FCMDC.201000030

SIRT1 and neuronal diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000030

Therapeutic role of sirtuins in neurodegenerative disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000030

Histone deacetylase inhibitors and neurodegenerative disorders: holding the promise

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000030

Sirtuins: critical regulators at the crossroads between cancer and aging

21 January 2018

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https://api.crossref.org/works/10.1002%2FCMDC.201000030

Cross-talk between aging and cancer: the epigenetic language

21 January 2018

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https://api.crossref.org/works/10.1002%2FCMDC.201000030

Negative regulation of the deacetylase SIRT1 by DBC1

21 January 2018

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https://api.crossref.org/works/10.1002%2FCMDC.201000030

Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes

21 January 2018

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Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator.

21 January 2018

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Downregulation of Sirt1 by antisense oligonucleotides induces apoptosis and enhances radiation sensitization in A549 lung cancer cells

21 January 2018

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Cancer-specific functions of SIRT1 enable human epithelial cancer cell growth and survival.

21 January 2018

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Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect.

21 January 2018

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Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides

21 January 2018

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Small-molecule inhibitors of histone acetyltransferase activity: identification and biological properties

21 January 2018

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epigenetic multiple ligands: mixed histone/protein methyltransferase, acetyltransferase, and class III deacetylase (sirtuin) inhibitors.

21 January 2018

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https://api.crossref.org/works/10.1002%2FCMDC.201000030

Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000030

Study of 1,4-dihydropyridine structural scaffold: discovery of novel sirtuin activators and inhibitors

21 January 2018

1 reference

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Thiobarbiturates as sirtuin inhibitors: virtual screening, free-energy calculations, and biological testing

21 January 2018

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Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening

21 January 2018

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https://api.crossref.org/works/10.1002%2FCMDC.201000030

Novel cambinol analogs as sirtuin inhibitors: synthesis, biological evaluation, and rationalization of activity.

21 January 2018

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Identification of a small molecule inhibitor of Sir2p

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000030

Structure-activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000030

SIRT1 regulates HIV transcription via Tat deacetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000030

Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000030

Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000030

A review of Sirt1 and Sirt1 modulators in cardiovascular and metabolic diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000030

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1002/CMDC.201000030

1 reference

14 September 2017

1 reference