(Q39716133)

14 September 2017

title

p53- and p21-dependent premature APC/C-Cdh1 activation in G2 is part of the long-term response to genotoxic stress (English)

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14 September 2017

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L Wiebusch

1

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14 September 2017

C Hagemeier

series ordinal

2

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14 September 2017

language of work or name

English

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publication date

12 April 2010

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14 September 2017

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14 September 2017

volume

29

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14 September 2017

issue

24

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14 September 2017

page(s)

3477-3489

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https://scigraph.springernature.com/pub.10.1038/onc.2010.99

14 September 2017

exact match

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cites work

p53-dependent apoptosis or growth arrest induced by different forms of radiation in U2OS cells: p21WAF1/CIP1 repression in UV induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

APC/C(Cdc20) controls the ubiquitin-mediated degradation of p21 in prometaphase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

DNA damage induced p53 downregulates Cdc20 by direct binding to its promoter causing chromatin remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

DNA damage signalling guards against activated oncogenes and tumour progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

Permanent cell cycle exit in G2 phase after DNA damage in normal human fibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

The nucleolar phosphatase Cdc14B is dispensable for chromosome segregation and mitotic exit in human cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

CDK inhibitors: cell cycle regulators and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

Requirement for p53 and p21 to sustain G2 arrest after DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

Growth stimulation leads to cellular senescence when the cell cycle is blocked

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

Emi1 is needed to couple DNA replication with mitosis but does not regulate activation of the mitotic APC/C

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

p53-Dependent regulation of Cdc6 protein stability controls cellular proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

p21Cip1/WAF1 mediates cyclin B1 degradation in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

An oncogene-induced DNA damage model for cancer development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

microRNAs join the p53 network--another piece in the tumour-suppression puzzle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

p53 enters the microRNA world

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

p130/p107/p105Rb-dependent transcriptional repression during DNA-damage-induced cell-cycle exit at G2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

The multiple battles fought by anti-apoptotic p21.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

ATP-dependent activation of p21WAF1/CIP1-associated Cdk2 by Cdc6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

CDC20, a potential cancer therapeutic target, is negatively regulated by p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

Regulation of the anaphase-promoting complex by the COP9 signalosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

Synchronization in the cell cycle by inhibitors of DNA replication induces histone H2AX phosphorylation: an indication of DNA damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

DNA damage triggers p21WAF1-dependent Emi1 down-regulation that maintains G2 arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

Cdh1-anaphase-promoting complex targets Skp2 for destruction in transforming growth factor beta-induced growth inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

p21/CDKN1A mediates negative regulation of transcription by p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

The APC/C inhibitor, Emi1, is essential for prevention of rereplication

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

Replication stress, defective S-phase checkpoint and increased death in Plk2-deficient human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

Stabilization of p53 and transactivation of its target genes in response to replication blockade

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

The anaphase promoting complex/cyclosome: a machine designed to destroy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

Genetic determinants of p53-induced apoptosis and growth arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

Phosphorylation of Skp2 regulated by CDK2 and Cdc14B protects it from degradation by APC(Cdh1) in G1 phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

Senescence, apoptosis and therapy--cutting the lifelines of cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

Identification of cell cycle regulatory genes as principal targets of p53-mediated transcriptional repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

DNA damage-induced downregulation of Cdc25C is mediated by p53 via two independent mechanisms: one involves direct binding to the cdc25C promoter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

Activation of Cdh1-dependent APC is required for G1 cell cycle arrest and DNA damage-induced G2 checkpoint in vertebrate cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

The unique N terminus of the UbcH10 E2 enzyme controls the threshold for APC activation and enhances checkpoint regulation of the APC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

Ubiquitination of p21Cip1/WAF1 by SCFSkp2: substrate requirement and ubiquitination site selection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

The emerging role of APC/CCdh1 in controlling differentiation, genomic stability and tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

The transcriptional targets of p53 in apoptosis control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21(CIP1/WAF1) and cyclin D proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

Polo-like kinase-1 is a target of the DNA damage checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

Myc suppression of the p21 Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.99

21 January 2018

Identifiers

DOI

10.1038/ONC.2010.99

1 reference

Dimensions Publication ID

14 September 2017

1036286393

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1 reference