(Q39718673)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20369225%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

title

Differences between amyloid toxicity in alpha and beta cells in human and mouse islets and the role of caspase-3 (English)

1 reference

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30 January 2020

6

1 reference

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30 January 2020

author name string

E Law

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20369225%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

S Lu

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20369225%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

T J Kieffer

3

1 reference

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30 January 2020

G L Warnock

4

1 reference

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30 January 2020

Z Ao

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20369225%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

L Marzban

7

1 reference

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30 January 2020

publication date

6 April 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20369225%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

number of pages

13

1 reference

inferred from page(s)

published in

Diabetologia

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20369225%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

volume

53

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20369225%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

issue

7

1 reference

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30 January 2020

page(s)

1415-1427

1 reference

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Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide.

30 January 2020

cites work

1 reference

12 December 2020

Ultrastructural evidence that apoptosis is the mechanism by which human amylin evokes death in RINm5F pancreatic islet beta-cells.

1 reference

12 December 2020

Widespread amyloid deposition in transplanted human pancreatic islets

1 reference

12 December 2020

Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus

1 reference

12 December 2020

Protofibrillar islet amyloid polypeptide permeabilizes synthetic vesicles by a pore-like mechanism that may be relevant to type II diabetes

1 reference

12 December 2020

Oxidative stress is induced by islet amyloid formation and time-dependently mediates amyloid-induced beta cell apoptosis

1 reference

12 December 2020

Small interfering RNA-mediated suppression of proislet amyloid polypeptide expression inhibits islet amyloid formation and enhances survival of human islets in culture

1 reference

12 December 2020

Rapid deposition of amyloid in human islets transplanted into nude mice.

1 reference

12 December 2020

Spontaneous diabetes in hemizygous human amylin transgenic mice that developed neither islet amyloid nor peripheral insulin resistance

1 reference

12 December 2020

Amylin-induced cytotoxicity is associated with activation of caspase-3 and MAP kinases

1 reference

12 December 2020

Islet amyloid polypeptide: pinpointing amino acid residues linked to amyloid fibril formation

1 reference

12 December 2020

Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients

1 reference

12 December 2020

Human islet amyloid polypeptide oligomers disrupt cell coupling, induce apoptosis, and impair insulin secretion in isolated human islets.

1 reference

12 December 2020

Aberrant processing of human proislet amyloid polypeptide results in increased amyloid formation

1 reference

12 December 2020

Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

1 reference

12 December 2020

Intracellular amyloid-like deposits contain unprocessed pro-islet amyloid polypeptide (proIAPP) in beta cells of transgenic mice overexpressing the gene for human IAPP and transplanted human islets.

1 reference

12 December 2020

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

1 reference

12 December 2020

Caspase-3-dependent beta-cell apoptosis in the initiation of autoimmune diabetes mellitus.

1 reference

12 December 2020

Impaired NH2-terminal processing of human proislet amyloid polypeptide by the prohormone convertase PC2 leads to amyloid formation and cell death

1 reference

12 December 2020

Islet amyloid: a complication of islet dysfunction or an aetiological factor in Type 2 diabetes?

1 reference

12 December 2020

Amyloid formation results in recurrence of hyperglycaemia following transplantation of human IAPP transgenic mouse islets

1 reference

12 December 2020

Membrane damage by human islet amyloid polypeptide through fibril growth at the membrane

1 reference

12 December 2020

Glucose- and time-dependence of islet amyloid formation in vitro

1 reference

12 December 2020

Type 2 diabetes, insulin secretion and beta-cell mass

1 reference

12 December 2020

Fibrillogenic amylin evokes islet beta-cell apoptosis through linked activation of a caspase cascade and JNK1.

1 reference

12 December 2020

The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles.

1 reference

12 December 2020

Successful versus failed adaptation to high-fat diet-induced insulin resistance: the role of IAPP-induced beta-cell endoplasmic reticulum stress

1 reference

12 December 2020

Evidence of cosecretion of islet amyloid polypeptide and insulin by beta-cells

1 reference

12 December 2020

Apoptotic pathways: ten minutes to dead

1 reference

12 December 2020

Processing of pro-islet amyloid polypeptide in the constitutive and regulated secretory pathways of beta cells

1 reference

12 December 2020

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

1 reference

12 December 2020

Amyloid ion channels: a common structural link for protein-misfolding disease

1 reference

12 December 2020

Co-localization of islet amyloid polypeptide and insulin in the B cell secretory granules of the human pancreatic islets

1 reference

12 December 2020

Fas-associated death receptor signaling evoked by human amylin in islet beta-cells

1 reference

12 December 2020

Calcium elevation in mouse pancreatic beta cells evoked by extracellular human islet amyloid polypeptide involves activation of the mechanosensitive ion channel TRPV4.

1 reference

12 December 2020

High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated beta-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes

1 reference

12 December 2020

Islet amyloid polypeptide and type 2 diabetes

1 reference

12 December 2020

Localization of the basement membrane heparan sulfate proteoglycan in islet amyloid deposits in type II diabetes mellitus

1 reference

12 December 2020

Prolonged exposure of pancreatic beta cells to raised glucose concentrations results in increased cellular content of islet amyloid polypeptide precursors

1 reference

12 December 2020

Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis

1 reference

12 December 2020

Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells

1 reference

12 December 2020

Islet amyloid: a long-recognized but underappreciated pathological feature of type 2 diabetes

1 reference

12 December 2020

Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes

1 reference

12 December 2020

Regulation of CD95/APO-1/Fas-induced apoptosis by protein phosphatases

1 reference

12 December 2020

Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers

1 reference

12 December 2020

Identification of a heparin binding domain in the N-terminal cleavage site of pro-islet amyloid polypeptide. Implications for islet amyloid formation

1 reference

12 December 2020

The cellular response to protein misfolding in the endoplasmic reticulum.

1 reference

12 December 2020

Differences in amyloid deposition in islets of transgenic mice expressing human islet amyloid polypeptide versus human islets implanted into nude mice

1 reference

12 December 2020

Fine structure of islets of Langerhans in insular amyloidosis

1 reference

12 December 2020