(Q39719791)

English

EphA2 mutation in lung squamous cell carcinoma promotes increased cell survival, cell invasion, focal adhesions, and mammalian target of rapamycin activation

scientific article published on April 2010

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scholarly article

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Europe PubMed Central

PMC publication ID

14 September 2017

EphA2 mutation in lung squamous cell carcinoma promotes increased cell survival, cell invasion, focal adhesions, and mammalian target of rapamycin activation (English)

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Europe PubMed Central

PMC publication ID

14 September 2017

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Everett E Vokes

11

object named as

Everett E Vokes

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Europe PubMed Central

14 September 2017

PMC publication ID

12

object named as

Ravi Salgia

1 reference

Europe PubMed Central

14 September 2017

PMC publication ID

6

object named as

Rajani Kanteti

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

author name string

Leonardo Faoro

1

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Europe PubMed Central

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14 September 2017

Patrick A Singleton

2

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Europe PubMed Central

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14 September 2017

Gustavo M Cervantes

3

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Europe PubMed Central

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14 September 2017

Frances E Lennon

4

1 reference

Europe PubMed Central

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14 September 2017

Nicholas W Choong

5

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Europe PubMed Central

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14 September 2017

Benjamin D Ferguson

7

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Europe PubMed Central

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14 September 2017

Aliya N Husain

8

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14 September 2017

Maria S Tretiakova

9

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14 September 2017

Nithya Ramnath

10

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14 September 2017

language of work or name

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publication date

1 April 2010

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14 September 2017

number of pages

11

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Journal of Biological Chemistry

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14 September 2017

285

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14 September 2017

24

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Europe PubMed Central

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14 September 2017

18575-18585

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2881783/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Targeting the mTOR signaling network for cancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881783

14 September 2017

Protein kinase C beta in malignant pleural mesothelioma

1 reference

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Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial

1 reference

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14 September 2017

Rapamycin inhibits F-actin reorganization and phosphorylation of focal adhesion proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881783

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Cortactin in tumor invasiveness

1 reference

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Suppression of programmed cell death 4 (PDCD4) protein expression by BCR-ABL-regulated engagement of the mTOR/p70 S6 kinase pathway

1 reference

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Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma

1 reference

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Cancer statistics, 2007

1 reference

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EphA2 overexpression is associated with angiogenesis in ovarian cancer

1 reference

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Patterns of EphA2 protein expression in primary and metastatic pancreatic carcinoma and correlation with genetic status

1 reference

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14 September 2017

Eph receptor signalling casts a wide net on cell behaviour

1 reference

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The interplay between Src and integrins in normal and tumor biology

1 reference

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Global and regional estimates of cancer mortality and incidence by site: II. Results for the global burden of disease 2000

1 reference

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Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake

1 reference

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Oncogenic kinase signalling

1 reference

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14 September 2017

Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881783

14 September 2017

Complexes of focal adhesion kinase (FAK) and Crk-associated substrate (p130(Cas)) are elevated in cytoskeleton-associated fractions following adhesion and Src transformation. Requirements for Src kinase activity and FAK proline-rich motifs

1 reference

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The related adhesion focal tyrosine kinase is tyrosine-phosphorylated after beta1-integrin stimulation in B cells and binds to p130cas

1 reference

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Primary structure of human fibronectin: differential splicing may generate at least 10 polypeptides from a single gene

1 reference

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14 September 2017

Expression of the receptor tyrosine kinase EphA2 is increased in smokers and predicts poor survival in non-small cell lung cancer

1 reference

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14 September 2017

SRC promotes survival and invasion of lung cancers with epidermal growth factor receptor abnormalities and is a potential candidate for molecular-targeted therapy.

1 reference

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14 September 2017

Selective targeting and potent control of tumor growth using an EphA2/CD3-Bispecific single-chain antibody construct

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881783

14 September 2017

Activation of the EGFR gene target EphA2 inhibits epidermal growth factor-induced cancer cell motility

1 reference

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14 September 2017

Intraperitoneal delivery of liposomal siRNA for therapy of advanced ovarian cancer

1 reference

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14 September 2017

EphA2 as a novel molecular marker and target in glioblastoma multiforme

1 reference

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14 September 2017

Dasatinib (BMS-354825) tyrosine kinase inhibitor suppresses invasion and induces cell cycle arrest and apoptosis of head and neck squamous cell carcinoma and non-small cell lung cancer cells

1 reference

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Somatic mutations of the protein kinase gene family in human lung cancer

1 reference

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14 September 2017

EphA2 expression is associated with aggressive features in ovarian carcinoma

1 reference

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Survival in early-stage non-small cell lung cancer

1 reference

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EphrinA1-induced cytoskeletal re-organization requires FAK and p130(cas).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881783

25 September 2017

Silencing the receptor EphA2 suppresses the growth and haptotaxis of malignant mesothelioma cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881783

20 August 2018

A kinase-dependent role for EphA2 receptor in promoting tumor growth and metastasis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881783

20 August 2018

EphA2: a determinant of malignant cellular behavior and a potential therapeutic target in pancreatic adenocarcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881783

20 August 2018

Correlation of EPHA2 overexpression with high microvessel count in human primary colorectal cancer

1 reference

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20 August 2018

Expression of EphA2 and E-cadherin in colorectal cancer: correlation with cancer metastasis.

1 reference

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20 August 2018

High-level expression of EphA2 receptor tyrosine kinase in prostatic intraepithelial neoplasia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881783

20 August 2018

Predictive value of the EphA2 receptor tyrosine kinase in lung cancer recurrence and survival.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881783

20 August 2018

EphA2 overexpression causes tumorigenesis of mammary epithelial cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881783

20 August 2018

The ephrin-A1 ligand and its receptor, EphA2, are expressed during tumor neovascularization

1 reference

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20 August 2018

Prognosis and survival in resected lung carcinoma based on the new international staging system

1 reference

https://pubmed.ncbi.nlm.nih.gov/20360610

12 December 2020

based on heuristic

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Prognostic assessment of 2,361 patients who underwent pulmonary resection for non-small cell lung cancer, stage I, II, and IIIA

1 reference

https://pubmed.ncbi.nlm.nih.gov/20360610

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M109.075085

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

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