(Q39726471)

20237263

14 September 2017

title

Loss of HRD1-mediated protein degradation causes amyloid precursor protein accumulation and amyloid-beta generation (English)

1 reference

14 September 2017

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6632277&resulttype=core&format=json

15 May 2020

author name string

Hiroshi Koike

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6632277&resulttype=core&format=json

15 May 2020

Ryo Saito

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6632277&resulttype=core&format=json

15 May 2020

Yoshihisa Kitamura

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6632277&resulttype=core&format=json

15 May 2020

Yasunobu Okuma

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6632277&resulttype=core&format=json

15 May 2020

Yasuyuki Nomura

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6632277&resulttype=core&format=json

15 May 2020

language of work or name

English

0 references

publication date

1 March 2010

1 reference

20237263

14 September 2017

published in

Journal of Neuroscience

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6632277&resulttype=core&format=json

15 May 2020

volume

30

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6632277&resulttype=core&format=json

15 May 2020

issue

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6632277&resulttype=core&format=json

15 May 2020

page(s)

3924-3932

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6632277&resulttype=core&format=json

Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response

15 May 2020

cites work

1 reference

12 December 2020

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

1 reference

12 December 2020

Aggresomes, inclusion bodies and protein aggregation

1 reference

12 December 2020

Alzheimer's disease: genes, proteins, and therapy

1 reference

12 December 2020

An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

1 reference

12 December 2020

Retro-translocation of proteins from the endoplasmic reticulum into the cytosol

1 reference

12 December 2020

A novel mechanism for the regulation of amyloid precursor protein metabolism

1 reference

12 December 2020

Human HRD1 protects against ER stress-induced apoptosis through ER-associated degradation

1 reference

12 December 2020

A novel mammalian endoplasmic reticulum ubiquitin ligase homologous to the yeast Hrd1

1 reference

12 December 2020

Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy

1 reference

12 December 2020

Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum

1 reference

12 December 2020

ER signaling in unfolded protein response

1 reference

12 December 2020

The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress

1 reference

12 December 2020

Amyloid beta induces neuronal cell death through ROS-mediated ASK1 activation

1 reference

12 December 2020

The role of cerebral amyloid beta accumulation in common forms of Alzheimer disease

1 reference

12 December 2020

The mammalian unfolded protein response

1 reference

12 December 2020

The ubiquitin-domain protein HERP forms a complex with components of the endoplasmic reticulum associated degradation pathway

1 reference

12 December 2020

ER stress and neurodegenerative diseases

1 reference

12 December 2020

S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration

1 reference

12 December 2020

Intracellular pathways of folded and misfolded amyloid precursor protein degradation.

1 reference

12 December 2020

Cellular tolerance of prion protein PrP in yeast involves proteolysis and the unfolded protein response

1 reference

12 December 2020

Have you HRD? Understanding ERAD is DOAble!

1 reference

12 December 2020

A luminal surveillance complex that selects misfolded glycoproteins for ER-associated degradation

1 reference

12 December 2020

Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins

1 reference

12 December 2020

Beta-amyloid precursor protein is a direct cleavage target of HtrA2 serine protease. Implications for the physiological function of HtrA2 in the mitochondria.

1 reference

12 December 2020

A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin

1 reference

12 December 2020

Ubiquitin ligase Hrd1 enhances the degradation and suppresses the toxicity of polyglutamine-expanded huntingtin

1 reference

12 December 2020

Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'

1 reference

12 December 2020

Signal integration in the endoplasmic reticulum unfolded protein response

1 reference

12 December 2020

HtrA2 regulates beta-amyloid precursor protein (APP) metabolism through endoplasmic reticulum-associated degradation.

1 reference

12 December 2020

A different pathway in the endoplasmic reticulum stress-induced expression of human HRD1 and SEL1 genes

1 reference

12 December 2020

Immunohistochemical localization of a ubiquitin ligase HRD1 in murine brain.

1 reference

12 December 2020

Novel functions of ubiquitin ligase HRD1 with transmembrane and proline-rich domains.

1 reference

12 December 2020

Amyloid precursor protein trafficking, processing, and function

1 reference

12 December 2020

gamma-secretase cleavage is distinct from endoplasmic reticulum degradation of the transmembrane domain of the amyloid precursor protein

1 reference

12 December 2020

Ubiquitin and the control of protein fate in the secretory and endocytic pathways

1 reference

12 December 2020

10.1523/JNEUROSCI.2422-09.2010

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6632277&resulttype=core&format=json

15 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6632277&resulttype=core&format=json

15 May 2020

20237263

1 reference