(Q39742473)

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An integrative genomic approach in oesophageal cells identifies TRB3 as a bile acid responsive gene, downregulated in Barrett's oesophagus, which regulates NF-kappaB activation and cytokine levels.

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20139130%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

An integrative genomic approach in oesophageal cells identifies TRB3 as a bile acid responsive gene, downregulated in Barrett's oesophagus, which regulates NF-kappaB activation and cytokine levels (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20139130%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

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John V Reynolds

5

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17 January 2020

Sinéad M. Smith

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17 January 2020

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17 January 2020

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Shane P Duggan

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17 January 2020

Fiona M Behan

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17 January 2020

Murat Kirca

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17 January 2020

Dermot Kelleher

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17 January 2020

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publication date

5 February 2010

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17 January 2020

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17 January 2020

31

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17 January 2020

936-945

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17 January 2020

5

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17 January 2020

describes a project that uses

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Proinflammatory cytokine and nuclear factor kappa-B expression along the inflammation-metaplasia-dysplasia-adenocarcinoma sequence in the esophagus

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ036

21 January 2018

Increased expression and secretion of interleukin-6 in patients with Barrett's esophagus.

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ036

21 January 2018

Gastroesophageal reflux disease-associated esophagitis induces endogenous cytokine production leading to motor abnormalities

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ036

21 January 2018

A COX-2 inhibitor prevents the esophageal inflammation-metaplasia-adenocarcinoma sequence in rats

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ036

21 January 2018

Duodenal reflux induces cyclooxygenase-2 in the esophageal mucosa of rats: evidence for involvement of bile acids

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ036

21 January 2018

Deoxycholic acid causes DNA damage in colonic cells with subsequent induction of caspases, COX-2 promoter activity and the transcription factors NF-kB and AP-1.

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ036

21 January 2018

Promoting effect of bile acids on colon carcinogenesis after intrarectal instillation of N-methyl-N'-nitro-N-nitrosoguanidine in rats.

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ036

21 January 2018

Bile acid deoxycholate induces differential subcellular localisation of the PKC isoenzymes beta 1, epsilon and delta in colonic epithelial cells in a sodium butyrate insensitive manner

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ036

21 January 2018

The bile acid deoxycholic acid (DCA) at neutral pH activates NF-kappaB and induces IL-8 expression in oesophageal cells in vitro

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ036

21 January 2018

Activation of the interleukin-6/STAT3 antiapoptotic pathway in esophageal cells by bile acids and low pH: relevance to barrett's esophagus.

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ036

21 January 2018

Transcriptional profiling suggests that Barrett's metaplasia is an early intermediate stage in esophageal adenocarcinogenesis.

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ036

21 January 2018

Low pH induces co-ordinate regulation of gene expression in oesophageal cells.

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ036

21 January 2018

In vitro acid exposure has a differential effect on apoptotic and proliferative pathways in a Barrett's adenocarcinoma cell line

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ036

21 January 2018

Bile acids as carcinogens in human gastrointestinal cancers

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ036

21 January 2018

Bile Acid Regulation of C/EBPβ, CREB, and c-Jun Function, via the Extracellular Signal-Regulated Kinase and c-Jun NH2-Terminal Kinase Pathways, Modulates the Apoptotic Response of Hepatocytes

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ036

21 January 2018

Bile acids induce cyclooxygenase-2 expression via the epidermal growth factor receptor in a human cholangiocarcinoma cell line

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ036

21 January 2018

COX-2 induction by unconjugated bile acids involves reactive oxygen species-mediated signalling pathways in Barrett's oesophagus and oesophageal adenocarcinoma

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ036

21 January 2018

Bile acids in combination with low pH induce oxidative stress and oxidative DNA damage: relevance to the pathogenesis of Barrett's oesophagus

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ036

21 January 2018

SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ036

21 January 2018

TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ036

21 January 2018

TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ036

21 January 2018

SINK Is a p65-interacting Negative Regulator of NF-κB-dependent Transcription

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ036

21 January 2018

Human tribbles, a protein family controlling mitogen-activated protein kinase cascades

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ036

21 January 2018

Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis.

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ036

21 January 2018

NF-kappaB activation in esophageal adenocarcinoma: relationship to Barrett's metaplasia, survival, and response to neoadjuvant chemoradiotherapy

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ036

21 January 2018

Activated nuclear factor-kappa B and cytokine profiles in the esophagus parallel tumor regression following neoadjuvant chemoradiotherapy

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ036

21 January 2018

Identifiers

10.1093/CARCIN/BGQ036

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20139130%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20139130%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

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