(Q39749640)

14 September 2017

title

Synthesis and biological evaluation of selective CXCR4 antagonists containing alkene dipeptide isosteres (English)

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14 September 2017

9

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14 September 2017

10

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14 September 2017

Eiichi Kodama

8

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Nobutaka Fujii

series ordinal

11

object named as

Nobutaka Fujii

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7

Takeshi Naito

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6

Hiroaki Ohno

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5

Noriko Tanahara

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14 September 2017

1

Tetsuo Narumi

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14 September 2017

Ryoko Hayashi

2

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14 September 2017

Kenji Tomita

series ordinal

3

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Kazuya Kobayashi

series ordinal

4

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14 September 2017

publication date

4 December 2009

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Organic and Biomolecular Chemistry

14 September 2017

published in

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14 September 2017

volume

8

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14 September 2017

issue

3

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14 September 2017

page(s)

616-621

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Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1

14 September 2017

cites work

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Pharmacophore identification of a specific CXCR4 inhibitor, T140, leads to development of effective anti-HIV agents with very high selectivity indexes

21 January 2018

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Conformational study of a highly specific CXCR4 inhibitor, T140, disclosing the close proximity of its intrinsic pharmacophores associated with strong anti-HIV activity

21 January 2018

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Molecular-size reduction of a potent CXCR4-chemokine antagonist using orthogonal combination of conformation- and sequence-based libraries

21 January 2018

1 reference

Structure-activity relationship studies on CXCR4 antagonists having cyclic pentapeptide scaffolds

21 January 2018

1 reference

Structure-activity relationship study of CXCR4 antagonists bearing the cyclic pentapeptide scaffold: identification of the new pharmacophore

21 January 2018

1 reference

Structure-activity relationship study on artificial CXCR4 ligands possessing the cyclic pentapeptide scaffold: the exploration of amino acid residues of pentapeptides by substitutions of several aromatic amino acids

21 January 2018

1 reference

Identification of novel low molecular weight CXCR4 antagonists by structural tuning of cyclic tetrapeptide scaffolds.

21 January 2018

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Structure-activity relationships of cyclic peptide-based chemokine receptor CXCR4 antagonists: disclosing the importance of side-chain and backbone functionalities

21 January 2018

1 reference

Stereoselective synthesis of [L-Arg-L/D-3-(2-naphthyl)alanine]-type (E)-alkene dipeptide isosteres and its application to the synthesis and biological evaluation of pseudopeptide analogues of the CXCR4 antagonist FC131.

21 January 2018

1 reference

Stereoselective synthesis of a set of two functionalized (E)-alkene dipeptide isosteres of L-amino acid-L-Glu and L-amino acid-D-Glu

21 January 2018

1 reference

Synthesis of the pro-gly dipeptide alkene isostere using olefin cross-metathesis

21 January 2018

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SmI2-mediated reduction of gamma,gamma-difluoro-alpha,beta-enoates with application to the synthesis of functionalized (Z)-fluoroalkene-type dipeptide isosteres

21 January 2018

1 reference

A novel one-pot reaction involving organocopper-mediated reduction/transmetalation/asymmetric alkylation, leading to the diastereoselective synthesis of functionalized (Z)-fluoroalkene dipeptide isosteres

21 January 2018

1 reference

Facile Synthesis of Fluoroalkenes by Palladium-Catalyzed Reductive Defluorination of Allylicgem-Difluorides

21 January 2018

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Diastereoselective synthesis of highly functionalized fluoroalkene dipeptide isosteres and its application to Fmoc-based solid-phase synthesis of a cyclic pentapeptide mimetic

21 January 2018

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Peptide bond mimicry by (E)-alkene and (Z)-fluoroalkene peptide isosteres: synthesis and bioevaluation of alpha-helical anti-HIV peptide analogues

21 January 2018

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Diastereoselective synthesis of new psi[(E)-CH=CMe]- and psi[(Z)-CH=CMe]-type alkene dipeptide isosteres by organocopper reagents and application to conformationally restricted cyclic RGD peptidomimetics.

21 January 2018

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Application of tri- and tetrasubstituted alkene dipeptide mimetics to conformational studies of cyclic RGD peptides

21 January 2018

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Trisubstituted (E)-alkene dipeptide isosteres as beta-turn promoters in the gramicidin S cyclodecapeptide scaffold

21 January 2018

1 reference

The effect of a trans-locked Gly-Pro alkene isostere on collagen triple helix stability

21 January 2018

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Amino acid-based synthesis of trifluoromethylalkene dipeptide isosteres by alcohol-assisted nucleophilic trifluoromethylation and organozinc-copper-mediated S(N)2' alkylation.

21 January 2018

1 reference

Chiral dipeptide mimics possessing a fluoroolefin moiety: a relevant tool for conformational and medicinal studies.

21 January 2018

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Synthesis and application of fluorescein- and biotin-labeled molecular probes for the chemokine receptor CXCR4.

21 January 2018

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4'-Ethynyl nucleoside analogs: potent inhibitors of multidrug-resistant human immunodeficiency virus variants in vitro

21 January 2018

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Altered drug sensitivity, fitness, and evolution of human immunodeficiency virus type 1 with pol gene mutations conferring multi-dideoxynucleoside resistance

21 January 2018

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Peptide Bond Isosteres: Ester or (E)-Alkene in the Backbone of the Collagen Triple Helix

21 January 2018

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Fluoro-Olefins as Peptidomimetic Inhibitors of Dipeptidyl Peptidases

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1039/B917236J

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14 September 2017

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