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The exocyst gene Sec10 regulates renal epithelial monolayer homeostasis and apoptotic sensitivity.
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Europe PubMed Central
PMC publication ID
4525081
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26040895%20AND%20SRC:MED&resulttype=core&format=json
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16 February 2020
title
The exocyst gene Sec10 regulates renal epithelial monolayer homeostasis and apoptotic sensitivity
(English)
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PMC publication ID
4525081
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16 February 2020
main subject
apoptotic process
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Exocyst complex component 5
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GOA release 2020-03-11
author
Noemi Polgar
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1
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4525081
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16 February 2020
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Amanda J Lee
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2
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4525081
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16 February 2020
Vanessa H Lui
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3
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4525081
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16 February 2020
Josephine A Napoli
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4
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4525081
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16 February 2020
Ben Fogelgren
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5
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4525081
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16 February 2020
publication date
3 June 2015
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16 February 2020
published in
American Journal of Physiology - Cell Physiology
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4525081
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16 February 2020
volume
309
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16 February 2020
issue
3
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4525081
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16 February 2020
page(s)
C190-201
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4525081
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16 February 2020
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Urothelial Defects from Targeted Inactivation of Exocyst Sec10 in Mice Cause Ureteropelvic Junction Obstructions
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Bringing balance by force: live cell extrusion controls epithelial cell numbers
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Phosphoinositide signaling regulates the exocyst complex and polarized integrin trafficking in directionally migrating cells
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The exocyst complex in exocytosis and cell migration
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The tumor suppressor adenomatous polyposis coli controls the direction in which a cell extrudes from an epithelium
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The exocyst protein Sec10 interacts with Polycystin-2 and knockdown causes PKD-phenotypes
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Thiazolidinediones inhibit MDCK cyst growth through disrupting oriented cell division and apicobasal polarity
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Apoptotic regulation of epithelial cellular extrusion
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Ciliopathies: an expanding disease spectrum
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A molecular network for de novo generation of the apical surface and lumen
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The Function of Two Rho Family GTPases Is Determined by Distinct Patterns of Cell Surface Localization
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15 June 2018
Exocyst Sec10 protects epithelial barrier integrity and enhances recovery following oxidative stress, by activation of the MAPK pathway
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P115 RhoGEF and microtubules decide the direction apoptotic cells extrude from an epithelium
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15 June 2018
The exocyst protein Sec10 is necessary for primary ciliogenesis and cystogenesis in vitro
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15 June 2018
Membrane association and functional regulation of Sec3 by phospholipids and Cdc42
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Exocyst requirement for endocytic traffic directed toward the apical and basolateral poles of polarized MDCK cells
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Human ADPKD primary cyst epithelial cells with a novel, single codon deletion in the PKD1 gene exhibit defective ciliary polycystin localization and loss of flow-induced Ca2+ signaling.
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Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization
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The exocyst localizes to the primary cilium in MDCK cells
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ARF6 controls post-endocytic recycling through its downstream exocyst complex effector
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15 June 2018
Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination
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15 June 2018
Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease
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Cdc42 interacts with the exocyst and regulates polarized secretion.
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15 June 2018
Exocyst is involved in cystogenesis and tubulogenesis and acts by modulating synthesis and delivery of basolateral plasma membrane and secretory proteins
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15 June 2018
Ksp-cadherin gene promoter. I. Characterization and renal epithelial cell-specific activity
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15 June 2018
Sec6/8 complex is recruited to cell-cell contacts and specifies transport vesicle delivery to the basal-lateral membrane in epithelial cells
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15 June 2018
The perennial organelle: assembly and disassembly of the primary cilium
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17 June 2018
Cell-polarity dynamics controls the mechanism of lumen formation in epithelial morphogenesis
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17 June 2018
Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia.
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17 June 2018
Primary cilia and signaling pathways in mammalian development, health and disease.
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20 August 2018
Morphological and biochemical analysis of Rac1 in three-dimensional epithelial cell cultures.
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20 August 2018
Epithelial-specific Cre/lox recombination in the developing kidney and genitourinary tract.
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20 August 2018
A minimal Ksp-cadherin promoter linked to a green fluorescent protein reporter gene exhibits tissue-specific expression in the developing kidney and genitourinary tract.
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20 August 2018
An epithelial cell destined for apoptosis signals its neighbors to extrude it by an actin- and myosin-dependent mechanism
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20 August 2018
Ksp-cadherin gene promoter. II. Kidney-specific activity in transgenic mice.
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20 August 2018
Kidney-Specific Gene Targeting
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21 January 2018
Identifiers
DOI
10.1152/AJPCELL.00011.2015
1 reference
stated in
Europe PubMed Central
PMC publication ID
4525081
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26040895%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 February 2020
PMC publication ID
4525081
1 reference
stated in
Europe PubMed Central
PMC publication ID
4525081
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26040895%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 February 2020
PubMed publication ID
26040895
1 reference
stated in
Europe PubMed Central
PMC publication ID
4525081
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26040895%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 February 2020
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