(Q36651169)

English

Human ADPKD primary cyst epithelial cells with a novel, single codon deletion in the PKD1 gene exhibit defective ciliary polycystin localization and loss of flow-induced Ca2+ signaling.

scientific article published on 7 November 2006

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scholarly article

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21 December 2019

Human ADPKD primary cyst epithelial cells with a novel, single codon deletion in the PKD1 gene exhibit defective ciliary polycystin localization and loss of flow-induced Ca2+ signaling (English)

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21 December 2019

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21 December 2019

Robert Bacallao

7

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21 December 2019

Angela Wandinger-Ness

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object named as

Angela Wandinger-Ness

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21 December 2019

author name string

Sandro Rossetti

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21 December 2019

Lianwei Jiang

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21 December 2019

Peter C Harris

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21 December 2019

Ursa Brown-Glaberman

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21 December 2019

Seth L Alper

8

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21 December 2019

publication date

7 November 2006

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21 December 2019

American Journal of Physiology - Renal Physiology

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21 December 2019

292

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21 December 2019

3

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21 December 2019

F930-45

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21 December 2019

describes a project that uses

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11 June 2022

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based on heuristic

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The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

30 September 2017

Polycystin-2 traffics to cilia independently of polycystin-1 by using an N-terminal RVxP motif

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

30 September 2017

Polycystin-1, STAT6, and P100 function in a pathway that transduces ciliary mechanosensation and is activated in polycystic kidney disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

30 September 2017

Cilia and centrosomes: a unifying pathogenic concept for cystic kidney disease?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

30 September 2017

An incredible decade for the primary cilium: a look at a once-forgotten organelle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

30 September 2017

Polycystin 2 interacts with type I inositol 1,4,5-trisphosphate receptor to modulate intracellular Ca2+ signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

30 September 2017

Characterization of single channel currents from primary cilia of renal epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

30 September 2017

Mechanoregulation of intracellular Ca2+ concentration is attenuated in collecting duct of monocilium-impaired orpk mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

30 September 2017

Expression of polycystin-1 enhances endoplasmic reticulum calcium uptake and decreases capacitative calcium entry in ATP-stimulated MDCK cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

30 September 2017

Localization of transient receptor potential ion channels in primary and motile cilia of the female murine reproductive organs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

30 September 2017

Molecular pathogenesis of ADPKD: the polycystin complex gets complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

30 September 2017

A physiological view of the primary cilium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

30 September 2017

Membrane trafficking of angiotensin receptor type-1 and mechanochemical signal transduction in proximal tubule cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

30 September 2017

Bilayer-dependent inhibition of mechanosensitive channels by neuroactive peptide enantiomers.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

30 September 2017

A polycystin-1 multiprotein complex is disrupted in polycystic kidney disease cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

30 September 2017

Pkd2 haploinsufficiency alters intracellular calcium regulation in vascular smooth muscle cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

30 September 2017

Histopathological analysis of renal cystic epithelia in the Pkd2WS25/- mouse model of ADPKD.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

30 September 2017

Native polycystin 2 functions as a plasma membrane Ca2+-permeable cation channel in renal epithelia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

30 September 2017

Removal of the MDCK cell primary cilium abolishes flow sensing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

30 September 2017

Nephron number in patients with primary hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

30 September 2017

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

30 September 2017

Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

30 September 2017

The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

30 September 2017

Altered expression pattern of polycystin-2 in acute and chronic renal tubular diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

30 September 2017

Polycystin-2 localizes to kidney cilia and the ciliary level is elevated in orpk mice with polycystic kidney disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

30 September 2017

Identification, characterization, and localization of a novel kidney polycystin-1-polycystin-2 complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

30 September 2017

Cation channel regulation by COOH-terminal cytoplasmic tail of polycystin-1: mutational and functional analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

30 September 2017

Polycystin-2 is an intracellular calcium release channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

30 September 2017

Bending the MDCK cell primary cilium increases intracellular calcium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

30 September 2017

Polaris, a protein involved in left-right axis patterning, localizes to basal bodies and cilia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

30 September 2017

Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

30 September 2017

Mutation analysis of the entire PKD1 gene: genetic and diagnostic implications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

30 September 2017

The cytoplasmic C-terminal fragment of polycystin-1 regulates a Ca2+-permeable cation channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

30 September 2017

Shear stress-mediated NO production in inner medullary collecting duct cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

30 September 2017

Compromised cytoarchitecture and polarized trafficking in autosomal dominant polycystic kidney disease cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

30 September 2017

Identification and characterization of polycystin-2, the PKD2 gene product

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

30 September 2017

Coordinate expression of the autosomal dominant polycystic kidney disease proteins, polycystin-2 and polycystin-1, in normal and cystic tissue.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

30 September 2017

Distinct Ca2+- and cAMP-dependent anion conductances in the apical membrane of polarized T84 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

30 September 2017

Homo- and heterodimeric interactions between the gene products of PKD1 and PKD2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

30 September 2017

Polycystin: in vitro synthesis, in vivo tissue expression, and subcellular localization identifies a large membrane-associated protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

30 September 2017

PKD1 interacts with PKD2 through a probable coiled-coil domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

30 September 2017

Polycystin, the polycystic kidney disease 1 protein, is expressed by epithelial cells in fetal, adult, and polycystic kidney

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

30 September 2017

Overexpression of PKD1 causes polycystic kidney disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

28 June 2018

A mathematical model of the inner medullary collecting duct of the rat: pathways for Na and K transport.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

28 June 2018

Loss of primary cilia results in deregulated and unabated apical calcium entry in ARPKD collecting duct cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

20 September 2018

IP3-mediated Ca2+ increases do not involve the ryanodine receptor, but ryanodine receptor antagonists reduce IP3-mediated Ca2+ increases in guinea-pig colonic smooth muscle cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

20 September 2018

Axial flow modulates proximal tubule NHE3 and H-ATPase activities by changing microvillus bending moments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

20 September 2018

Functional ryanodine receptor expression is required for NAADP-mediated local Ca2+ signaling in T-lymphocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

20 September 2018

TRPC1 forms the stretch-activated cation channel in vertebrate cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

20 September 2018

The intrarenal renin-angiotensin system in autosomal dominant polycystic kidney disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

20 September 2018

2-aminoethoxydiphenyl borate activates and sensitizes the heat-gated ion channel TRPV3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

20 September 2018

Luminal flow induces eNOS activation and translocation in the rat thick ascending limb

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

20 September 2018

Cellular and subcellular localization of the ARPKD protein; fibrocystin is expressed on primary cilia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

20 September 2018

The isolated polycystin-1 cytoplasmic COOH terminus prolongs ATP-stimulated Cl- conductance through increased Ca2+ entry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

20 September 2018

Effect of flow and stretch on the [Ca2+]i response of principal and intercalated cells in cortical collecting duct

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

20 September 2018

Functional analysis of PKD1 transgenic lines reveals a direct role for polycystin-1 in mediating cell-cell adhesion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

20 September 2018

Trans-heterozygous Pkd1 and Pkd2 mutations modify expression of polycystic kidney disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

20 September 2018

Epithelial Na(+) channels are regulated by flow

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

20 September 2018

ADPKD: a human disease altering Golgi function and basolateral exocytosis in renal epithelia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

20 September 2018

A human PKD1 transgene generates functional polycystin-1 in mice and is associated with a cystic phenotype.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

20 September 2018

Microwaving for double indirect immunofluorescence with primary antibodies from the same species and for staining of mouse tissues with mouse monoclonal antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

20 September 2018

The proximal tubule phenotype and its disruption in acute renal failure and polycystic kidney disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

20 September 2018

Polycystin expression is temporally and spatially regulated during renal development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

20 September 2018

The molecular basis of focal cyst formation in human autosomal dominant polycystic kidney disease type I.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586432

20 September 2018

Effect of lipid modification on progression of coronary calcification

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00285.2006

21 January 2018

Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00285.2006

21 January 2018

Prevalence of abnormal urinary albumin excretion rate in hypertensive patients with impaired fasting glucose and its association with cardiovascular disease

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00285.2006

21 January 2018

Polaris, a protein disrupted in orpk mutant mice, is required for assembly of renal cilium

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00285.2006

21 January 2018

Loss of Polycystin-1 in Human Cyst-Lining Epithelia Leads to Ciliary Dysfunction

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00285.2006

21 January 2018

Late onset of renal and hepatic cysts in Pkd1-targeted heterozygotes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17090781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polycystin-1 expression in PKD1, early-onset PKD1, and TSC2/PKD1 cystic tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/17090781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium restores a normal proliferation phenotype in human polycystic kidney disease epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17090781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunological detection of polycystin-1 in human kidney

1 reference

https://pubmed.ncbi.nlm.nih.gov/17090781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A complete mutation screen of the ADPKD genes by DHPLC

1 reference

https://pubmed.ncbi.nlm.nih.gov/17090781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Delayed cystogenesis and increased ciliogenesis associated with the re-expression of polaris in Tg737 mutant mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17090781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ontogeny of flow-stimulated potassium secretion in rabbit cortical collecting duct: functional and molecular aspects

1 reference

https://pubmed.ncbi.nlm.nih.gov/17090781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1152/AJPRENAL.00285.2006

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17090781%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17090781%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17090781%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

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