(Q39778453)

English

Preclinical evaluation of linear HPMA-doxorubicin conjugates with pH-sensitive drug release: efficacy, safety, and immunomodulating activity in murine model

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

Preclinical evaluation of linear HPMA-doxorubicin conjugates with pH-sensitive drug release: efficacy, safety, and immunomodulating activity in murine model (English)

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

1 reference

based on heuristic

inferred from title

8

object named as

Karel Ulbrich

0 references

3

object named as

Tomas Etrych

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

Blanka Říhová

9

object named as

Blanka Rihova

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

author name string

Milada Sirova

1

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

Tomas Mrkvan

2

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

Petr Chytil

4

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

Pavel Rossmann

5

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

Marketa Ibrahimova

6

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

Lubomir Kovar

7

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

Karel Ulbrich

8

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

publication date

6 November 2009

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

Pharmaceutical Research

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

27

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Europe PubMed Central

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14 September 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

200-208

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

Drug-polymer conjugates containing acid-cleavable bonds

1 reference

https://api.crossref.org/works/10.1007%2FS11095-009-9999-7

21 January 2018

Modification of host antitumor defense mechanisms in mice by progressively growing tumor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19894105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Doxorubicin bound to a HPMA copolymer carrier through hydrazone bond is effective also in a cancer cell line with a limited content of lysosomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19894105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytostatic and immunomobilizing activities of polymer-bound drugs: experimental and first clinical data

1 reference

https://pubmed.ncbi.nlm.nih.gov/19894105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I clinical and pharmacokinetic study of PK1 [N-(2-hydroxypropyl)methacrylamide copolymer doxorubicin]: first member of a new class of chemotherapeutic agents-drug-polymer conjugates. Cancer Research Campaign Phase I/II Committee

1 reference

https://pubmed.ncbi.nlm.nih.gov/19894105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs

1 reference

https://pubmed.ncbi.nlm.nih.gov/19894105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acid pH in tumors and its potential for therapeutic exploitation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19894105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biocompatibility of N-(2-hydroxypropyl) methacrylamide copolymers containing adriamycin. Immunogenicity, and effect on haematopoietic stem cells in bone marrow in vivo and mouse splenocytes and human peripheral blood lymphocytes in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/19894105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antibody-targeted polymer-doxorubicin conjugates with pH-controlled activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19894105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19894105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Water soluble polymers in tumor targeted delivery

1 reference

https://pubmed.ncbi.nlm.nih.gov/19894105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunomodulating activities of soluble synthetic polymer-bound drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/19894105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antibody-directed affinity therapy applied to the immune system: in vivo effectiveness and limited toxicity of daunomycin conjugated to HPMA copolymers and targeting antibody

1 reference

https://pubmed.ncbi.nlm.nih.gov/19894105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tyrosinamide residues enhance pinocytic capture of N-(2-hydroxypropyl)methacrylamide copolymers

1 reference

https://pubmed.ncbi.nlm.nih.gov/19894105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytotoxicity and immunostimulation: double attack on cancer cells with polymeric therapeutics

1 reference

https://pubmed.ncbi.nlm.nih.gov/19894105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New HPMA copolymers containing doxorubicin bound via pH-sensitive linkage: synthesis and preliminary in vitro and in vivo biological properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/19894105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overcoming immunoescape mechanisms of BCL1 leukemia and induction of CD8+ T-cell-mediated BCL1-specific resistance in mice cured by targeted polymer-bound doxorubicin

1 reference

https://pubmed.ncbi.nlm.nih.gov/19894105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calreticulin exposure dictates the immunogenicity of cancer cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/19894105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemotherapy based on HPMA copolymer conjugates with pH-controlled release of doxorubicin triggers anti-tumor immunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19894105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HPMA copolymer platinates as novel antitumour agents: in vitro properties, pharmacokinetics and antitumour activity in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/19894105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of a carcinogen-induced murine B lymphocyte cell line of C3H/eB origin

1 reference

https://pubmed.ncbi.nlm.nih.gov/19894105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellularly biorecognizable derivatives of 5-fluorouracil. Implications for site-specific delivery in the human condition

1 reference

https://pubmed.ncbi.nlm.nih.gov/19894105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HPMA copolymers containing doxorubicin bound by a proteolytically or hydrolytically cleavable bond: comparison of biological properties in vitro.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19894105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The same drug but a different mechanism of action: comparison of free doxorubicin with two different N-(2-hydroxypropyl)methacrylamide copolymer-bound doxorubicin conjugates in EL-4 cancer cell line

1 reference

https://pubmed.ncbi.nlm.nih.gov/19894105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cumulative and irreversible cardiac mitochondrial dysfunction induced by doxorubicin

1 reference

https://pubmed.ncbi.nlm.nih.gov/19894105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acquired and specific immunological mechanisms co-responsible for efficacy of polymer-bound drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/19894105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Doxorubicin-induced cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19894105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New hydrazone derivatives of adriamycin and their immunoconjugates--a correlation between acid stability and cytotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19894105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunogenic cancer cell death: a key-lock paradigm

1 reference

https://pubmed.ncbi.nlm.nih.gov/19894105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HPMA based macromolecular therapeutics: internalization, intracellular pathway and cell death depend on the character of covalent bond between the drug and the peptidic spacer and also on spacer composition

1 reference

https://pubmed.ncbi.nlm.nih.gov/19894105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of systemic antitumour resistance with targeted polymers

1 reference

https://pubmed.ncbi.nlm.nih.gov/19894105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conjugates of doxorubicin with graft HPMA copolymers for passive tumor targeting

1 reference

https://pubmed.ncbi.nlm.nih.gov/19894105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cis-aconityl spacer between daunomycin and macromolecular carriers: A model of pH-sensitive linkage releasing drug from a lysosomotropic conjugate

1 reference

https://pubmed.ncbi.nlm.nih.gov/19894105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HPMA copolymers with pH-controlled release of doxorubicin: in vitro cytotoxicity and in vivo antitumor activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19894105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment with HPMA copolymer-based doxorubicin conjugate containing human immunoglobulin induces long-lasting systemic anti-tumour immunity in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19894105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug-HPMA-HuIg conjugates effective against human solid cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19894105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of molecular weight (Mw) of N-(2-hydroxypropyl)methacrylamide copolymers on body distribution and rate of excretion after subcutaneous, intraperitoneal, and intravenous administration to rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19894105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preclinical evaluation of the cardiotoxicity of PK2: a novel HPMA copolymer-doxorubicin-galactosamine conjugate antitumour agent

1 reference

https://pubmed.ncbi.nlm.nih.gov/19894105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polymeric drugs based on conjugates of synthetic and natural macromolecules. I. Synthesis and physico-chemical characterisation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19894105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polymer conjugates as anticancer nanomedicines

1 reference

https://pubmed.ncbi.nlm.nih.gov/19894105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficacy of the chemotherapeutic action of HPMA copolymer-bound doxorubicin in a solid tumor model of ovarian carcinoma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19894105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polymeric anticancer drugs with pH-controlled activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19894105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic drug targeting: phase I evaluation of polymer-bound doxorubicin

1 reference

https://pubmed.ncbi.nlm.nih.gov/19894105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced cardiotoxicity of doxorubicin given in the form of N-(2-hydroxypropyl)methacrylamide conjugates: and experimental study in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/19894105

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S11095-009-9999-7

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

release_rwukfmz6jjaubpndimzhk3ucgi

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

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