(Q39780931)

English

Loss of function of the influenza A virus NS1 protein promotes apoptosis but this is not due to a failure to activate phosphatidylinositol 3-kinase (PI3K).

scientific article published on 31 October 2009

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scholarly article

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Europe PubMed Central

PubMed publication ID

14 September 2017

Loss of function of the influenza A virus NS1 protein promotes apoptosis but this is not due to a failure to activate phosphatidylinositol 3-kinase (PI3K). (English)

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

author name string

David Jackson

1

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Europe PubMed Central

PubMed publication ID

14 September 2017

Marian J Killip

2

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

Caroline S Galloway

3

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

Rupert J Russell

4

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Europe PubMed Central

PubMed publication ID

14 September 2017

Richard E Randall

5

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Europe PubMed Central

PubMed publication ID

14 September 2017

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publication date

31 October 2009

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Europe PubMed Central

PubMed publication ID

14 September 2017

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Europe PubMed Central

PubMed publication ID

14 September 2017

396

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Europe PubMed Central

PubMed publication ID

14 September 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

94-105

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

Degradation of STAT1 and STAT2 by the V proteins of simian virus 5 and human parainfluenza virus type 2, respectively: consequences for virus replication in the presence of alpha/beta and gamma interferons

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Host defense, viruses and apoptosis

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Biophysical characterization of the complex between double-stranded RNA and the N-terminal domain of the NS1 protein from influenza A virus: evidence for a novel RNA-binding mode

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Specificity and mechanism of action of some commonly used protein kinase inhibitors

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Influenza A virus NS1 protein activates the PI3K/Akt pathway to mediate antiapoptotic signaling responses

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Programmed cell death (apoptosis) in human monocytes infected by influenza A virus

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Influenza virus NS1 protein inhibits pre-mRNA splicing and blocks mRNA nucleocytoplasmic transport

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Virus clearance through apoptosis-dependent phagocytosis of influenza A virus-infected cells by macrophages

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TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity

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Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I

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Exploring the specificity of the PI3K family inhibitor LY294002.

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The influenza A virus PB1-F2 protein targets the inner mitochondrial membrane via a predicted basic amphipathic helix that disrupts mitochondrial function

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7 January 2021

NS1 protein of influenza A virus inhibits the function of intracytoplasmic pathogen sensor, RIG-I

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7 January 2021

Influenza A virus NS1 protein binds p85beta and activates phosphatidylinositol-3-kinase signaling

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7 January 2021

Binding of influenza A virus NS1 protein to the inter-SH2 domain of p85 suggests a novel mechanism for phosphoinositide 3-kinase activation

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7 January 2021

The multifunctional NS1 protein of influenza A viruses

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Opposite effects of wortmannin and 2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride on toll-like receptor-mediated nitric oxide production: negative regulation of nuclear factor-{kappa}B by phosphoinositide 3-kinase

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7 January 2021

Replication of influenza A and B viruses in human diploid cells

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The NPro Product of Bovine Viral Diarrhea Virus Inhibits DNA Binding by Interferon Regulatory Factor 3 and Targets It for Proteasomal Degradation

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Importance of mRNA secondary structural elements for the expression of influenza virus genes

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A novel function of eIF2alpha kinases as inducers of the phosphoinositide-3 kinase signaling pathway

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LY294002 inhibits LPS-induced NO production through a inhibition of NF-kappaB activation: independent mechanism of phosphatidylinositol 3-kinase

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7 January 2021

Multiple anti-interferon actions of the influenza A virus NS1 protein

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Physiological significance of apoptosis in animal virus infection

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7 January 2021

LY303511 (2-piperazinyl-8-phenyl-4H-1-benzopyran-4-one) acts via phosphatidylinositol 3-kinase-independent pathways to inhibit cell proliferation via mammalian target of rapamycin (mTOR)- and non-mTOR-dependent mechanisms

1 reference

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7 January 2021

Influenza a virus polymerase is an integral component of the CPSF30-NS1A protein complex in infected cells

1 reference

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7 January 2021

Avian influenza virus A/HK/483/97(H5N1) NS1 protein induces apoptosis in human airway epithelial cells.

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Binding of the influenza A virus NS1 protein to PKR mediates the inhibition of its activation by either PACT or double-stranded RNA.

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AKT/PKB signaling: navigating downstream

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Inhibition of retinoic acid-inducible gene I-mediated induction of beta interferon by the NS1 protein of influenza A virus

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The primary function of RNA binding by the influenza A virus NS1 protein in infected cells: Inhibiting the 2'-5' oligo (A) synthetase/RNase L pathway

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10.1016/J.VIROL.2009.10.004

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Europe PubMed Central

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14 September 2017

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14 September 2017

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