(Q39781678)

14 September 2017

pH-dependent antitumor activity of proton pump inhibitors against human melanoma is mediated by inhibition of tumor acidity (English)

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14 September 2017

7

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14 September 2017

13

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15

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14 September 2017

Martina Borghi

4

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Rossella Canese

Rossella Canese

2

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Angelo De Milito

Angelo De Milito

1

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Stefano Fais

Stefano Fais

16

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Mario Santinami

Mario Santinami

12

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author name string

Maria Lucia Marino

3

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14 September 2017

Manuela Iero

5

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14 September 2017

Antonello Villa

6

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14 September 2017

Francesco Lozupone

8

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14 September 2017

Elisabetta Iessi

9

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14 September 2017

Mariantonia Logozzi

10

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14 September 2017

Pamela Della Mina

11

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14 September 2017

Franca Podo

14

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14 September 2017

language of work or name

English

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publication date

1 July 2010

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International Journal of Cancer

14 September 2017

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14 September 2017

127

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14 September 2017

1

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14 September 2017

207-219

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Meta-analysis of phase II cooperative group trials in metastatic stage IV melanoma to determine progression-free and overall survival benchmarks for future phase II trials

14 September 2017

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Cancer cell metabolism: Warburg and beyond

21 January 2018

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Tumor acidity, chemoresistance and proton pump inhibitors.

21 January 2018

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Targeting vacuolar H+-ATPases as a new strategy against cancer

21 January 2018

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Drug resistance and the solid tumor microenvironment

21 January 2018

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A microenvironmental model of carcinogenesis.

21 January 2018

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Studies of human tumors by MRS: a review

21 January 2018

1 reference

21 January 2018

Are cancer cells acidic?

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Clastogenicity of low pH to various cultured mammalian cells

21 January 2018

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Acidic pH enhances the invasive behavior of human melanoma cells

21 January 2018

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Effect of proton pump inhibitor pretreatment on resistance of solid tumors to cytotoxic drugs

21 January 2018

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Intracellular acidification triggered by mitochondrial-derived hydrogen peroxide is an effector mechanism for drug-induced apoptosis in tumor cells

21 January 2018

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The vacuolar (H+)-ATPases--nature's most versatile proton pumps

21 January 2018

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Vacuolar H+-ATPase in human breast cancer cells with distinct metastatic potential: distribution and functional activity

21 January 2018

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The growth and metastasis of human hepatocellular carcinoma xenografts are inhibited by small interfering RNA targeting to the subunit ATP6L of proton pump

21 January 2018

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Small interfering RNA targeting the subunit ATP6L of proton pump V-ATPase overcomes chemoresistance of breast cancer cells

21 January 2018

1 reference

Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology

21 January 2018

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Omeprazole and bafilomycin, two proton pump inhibitors: differentiation of their effects on gastric, kidney and bone H(+)-translocating ATPases

21 January 2018

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Proton pump inhibitors induce apoptosis of human B-cell tumors through a caspase-independent mechanism involving reactive oxygen species.

21 January 2018

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Selective induction of apoptosis with proton pump inhibitor in gastric cancer cells

21 January 2018

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An Overview of Proton Pump Inhibitors

21 January 2018

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Replacement of oral proton pump inhibitors with intravenous pantoprazole to effectively control gastric acid hypersecretion in patients with Zollinger-Ellison syndrome

21 January 2018

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Bafilomycin A1 induces apoptosis in the human pancreatic cancer cell line Capan-1.

21 January 2018

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Specific inhibitors of vacuolar type H(+)-ATPases induce apoptotic cell death.

21 January 2018

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Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate

21 January 2018

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BRAF alterations are associated with complex mutational profiles in malignant melanoma.

21 January 2018

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Guidelines on the recognition of pain, distress and discomfort in experimental animals and an hypothesis for assessment

21 January 2018

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Function of a subunit isoforms of the V-ATPase in pH homeostasis and in vitro invasion of MDA-MB231 human breast cancer cells

21 January 2018

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Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis

21 January 2018

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A role for intracellular pH in membrane IgM-mediated cell death of human B lymphomas

21 January 2018

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Effect of human natural killer and gammadelta T cells on the growth of human autologous melanoma xenografts in SCID mice

21 January 2018

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Proton pump inhibitors: an update of their clinical use and pharmacokinetics

21 January 2018

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Tumor cell metabolism: cancer's Achilles' heel

21 January 2018

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An acidic environment leads to p53 dependent induction of apoptosis in human adenoma and carcinoma cell lines: implications for clonal selection during colorectal carcinogenesis.

21 January 2018

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Cannibalism of live lymphocytes by human metastatic but not primary melanoma cells

21 January 2018

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Vacuolar H(+)-ATPase: functional mechanisms and potential as a target for cancer chemotherapy.

21 January 2018

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Na+/H+ exchanger-dependent intracellular alkalinization is an early event in malignant transformation and plays an essential role in the development of subsequent transformation-associated phenotypes.

21 January 2018

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Events in apoptosis. Acidification is downstream of protease activation and BCL-2 protection

21 January 2018

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Caspase-8-mediated intracellular acidification precedes mitochondrial dysfunction in somatostatin-induced apoptosis.

21 January 2018

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Recent progress in tumor pH targeting nanotechnology

21 January 2018

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Enhancement of chemotherapy by manipulation of tumour pH.

21 January 2018

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Bicarbonate increases tumor pH and inhibits spontaneous metastases

21 January 2018

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The role of acidity in solid tumour growth and invasion

21 January 2018

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Acute metabolic alkalosis enhances response of C3H mouse mammary tumors to the weak base mitoxantrone

21 January 2018

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Suppression of human solid tumor growth in mice by intratumor and systemic inoculation of histidine-rich and pH-dependent host defense-like lytic peptides

21 January 2018

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From basic research to the bedside: efficacy of topical treatment with pseudocatalase PC-KUS in 71 children with vitiligo.

21 January 2018

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Omeprazole inhibits IL-4 and IL-13 signaling signal transducer and activator of transcription 6 activation and reduces lung inflammation in murine asthma.

21 January 2018

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Proton pump inhibitors: actions and reactions.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/IJC.25009

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14 September 2017

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