(Q39791603)

14 September 2017

title

Modeling the effect of the RB tumor suppressor on disease progression: dependence on oncogene network and cellular context (English)

1 reference

14 September 2017

J L Dean

1

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14 September 2017

A K McClendon

series ordinal

2

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14 September 2017

K R Stengel

series ordinal

3

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14 September 2017

E S Knudsen

series ordinal

4

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14 September 2017

language of work or name

English

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publication date

5 October 2009

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14 September 2017

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14 September 2017

volume

29

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14 September 2017

issue

1

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14 September 2017

page(s)

68-80

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https://scigraph.springernature.com/pub.10.1038/onc.2009.313

14 September 2017

exact match

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cites work

Ras links growth factor signaling to the cell cycle machinery via regulation of cyclin D1 and the Cdk inhibitor p27KIP1.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.313

Deregulation of p27 by oncogenic signaling and its prognostic significance in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.313

Ras induces elevation of E2F-1 mRNA levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.313

Hitting their targets: an emerging picture of E2F and cell cycle control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.313

E2F-associated chromatin modifiers and cell cycle control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.313

Cellular mechanisms of tumour suppression by the retinoblastoma gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.313

Pocket proteins and cell cycle control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.313

Ras proteins in the control of the cell cycle and cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.313

Surprising dependency for retinoblastoma protein in ras-mediated tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.313

The regulation of E2F by pRB-family proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.313

Induction of apoptosis in fibroblasts by c-myc protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.313

21 January 2018

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.313

Mediation of c-Myc-induced apoptosis by p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.313

The retinoblastoma gene Rb and its family member p130 suppress lung adenocarcinoma induced by oncogenic K-Ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.313

Apoptotic signaling by c-MYC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.313

Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.313

Life and death decisions by the E2F transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.313

E2F-1 transcriptional activity is a critical determinant of Mdm2 antagonist-induced apoptosis in human tumor cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.313

Tailoring to RB: tumour suppressor status and therapeutic response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.313

p107 acts as a tumor suppressor in pRb-deficient epidermis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.313

Inactivation of the retinoblastoma susceptibility gene in human breast cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.313

A role for Myc in facilitating transcription activation by E2F1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.313

Ras transformation results in an elevated level of cyclin D1 and acceleration of G1 progression in NIH 3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.313

Murine bilateral retinoblastoma exhibiting rapid-onset, metastatic progression and N-myc gene amplification

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.313

Human fibroblasts require the Rb family of tumor suppressors, but not p53, for PML-induced senescence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.313

Loss of the retinoblastoma tumor suppressor: differential action on transcriptional programs related to cell cycle control and immune function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.313

p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.313

The Rb/E2F pathway and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.313

Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.313

Mechanisms of apoptosis by c-Myc

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.313

PI3K induced actin filament remodeling through Akt and p70S6K1: implication of essential role in cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.313

Susceptibility of pRb-deficient epidermis to chemical skin carcinogenesis is dependent on the p107 allele dosage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.313

Distinct roles for RB loss on cell cycle control, cisplatin response, and immortalization in Schwann cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.313

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.313

Rb Regulates DNA damage response and cellular senescence through E2F-dependent suppression of N-ras isoprenylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.313

Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.313

RB status governs differential sensitivity to cytotoxic and molecularly-targeted therapeutic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.313

Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.313

The retinoblastoma protein and cell cycle control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.313

The retinoblastoma protein is required for Ras-induced oncogenic transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.313

Senescence of human fibroblasts induced by oncogenic Raf.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.313

Transformation by RAS oncogene decreases the width of substrate-spread fibroblasts but not their length

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.313

Unexpected roles for pRb in mouse skin carcinogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.313

Retinoblastoma deficiency increases chemosensitivity in lung cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.313

31 March 2020

Identifiers

DOI

10.1038/ONC.2009.313

1 reference

Dimensions Publication ID

14 September 2017

1000704047

0 references

1 reference