(Q37310199)

19 August 2017

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title

Apoptotic signaling by c-MYC. (English)

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19 August 2017

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B Hoffman

1

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PubMed ID

18955973

19 August 2017

D A Liebermann

series ordinal

2

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PubMed ID

18955973

19 August 2017

language of work or name

English

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publication date

1 October 2008

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19 August 2017

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19 August 2017

27

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19 August 2017

50

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19 August 2017

6462-6472

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https://scigraph.springernature.com/pub.10.1038/onc.2008.312

19 August 2017

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cites work

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

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Transgenic models of lymphoid neoplasia and development of a pan-hematopoietic vector

21 January 2018

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Deregulated c-Myc prematurely recruits both Type I and II CD95/Fas apoptotic pathways associated with terminal myeloid differentiation

21 January 2018

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Myc-Max-Mad: a transcription factor network controlling cell cycle progression, differentiation and death

21 January 2018

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A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex

21 January 2018

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Myc suppresses induction of the growth arrest genes gadd34, gadd45, and gadd153 by DNA-damaging agents

21 January 2018

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Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.312

The Max network gone mad.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.312

FoxO transcription factors suppress Myc-driven lymphomagenesis via direct activation of Arf.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.312

Expression of Fas ligand in activated T cells is regulated by c-Myc

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.312

c-Myc and caspase-2 are involved in activating Bax during cytotoxic drug-induced apoptosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.312

Mismatched nucleotides as the lesions responsible for radiosensitization with gemcitabine: a new paradigm for antimetabolite radiosensitizers

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.312

Induction of cell cycle progression and acceleration of apoptosis are two separable functions of c-Myc: transrepression correlates with acceleration of apoptosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.312

The c-myc apoptotic response is not intrinsic to blocking terminal myeloid differentiation

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.312

The c-Myc target gene network

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.312

The great MYC escape in tumorigenesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.312

Specific requirement for Bax, not Bak, in Myc-induced apoptosis and tumor suppression in vivo

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.312

Bim is a suppressor of Myc-induced mouse B cell leukemia

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.312

Bcl-2 is an apoptotic target suppressed by both c-Myc and E2F-1.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.312

Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.312

Apoptosis triggered by Myc-induced suppression of Bcl-X(L) or Bcl-2 is bypassed during lymphomagenesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.312

The role of c-myc in cell growth

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.312

Induction of apoptosis in fibroblasts by c-myc protein

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.312

Transient excess of MYC activity can elicit genomic instability and tumorigenesis

21 January 2018

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RIP1, a kinase on the crossroads of a cell's decision to live or die

21 January 2018

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Mechanisms of c-myc-mediated transcriptional repression of growth arrest genes

21 January 2018

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Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.312

Mediation of c-Myc-induced apoptosis by p53.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.312

p53-Dependent transcriptional repression of c-myc is required for G1 cell cycle arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

The proto-oncogene c-myc in hematopoietic development and leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

The MAX-interacting transcription factor network

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

c-Myc induces cytochrome c release in Rat1 fibroblasts by increasing outer mitochondrial membrane permeability in a Bid-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

c-Myc overexpression sensitizes Bim-mediated Bax activation for apoptosis induced by histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) through regulating Bcl-2/Bcl-xL expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

c-Myc functionally cooperates with Bax to induce apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

A 'non-canonical' DNA-binding element mediates the response of the Fas-ligand promoter to c-Myc.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

Endogenous bcl-2 is not required for the development of Emu-myc-induced B-cell lymphoma

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.312

Induction of TNF-sensitive cellular phenotype by c-Myc involves p53 and impaired NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

Myc goes global: new tricks for an old oncogene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

Interleukin-6 contributes to Mcl-1 up-regulation and TRAIL resistance via an Akt-signaling pathway in cholangiocarcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

NFkappaB activation by Fas is mediated through FADD, caspase-8, and RIP and is inhibited by FLIP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

Caspases 3 and 7: key mediators of mitochondrial events of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

Myeloid differentiation (MyD)/growth arrest DNA damage (GADD) genes in tumor suppression, immunity and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

Respiratory syncytial virus inhibits granulocyte apoptosis through a phosphatidylinositol 3-kinase and NF-kappaB-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

The world according to MYC. Conference on MYC and the transcriptional control of proliferation and oncogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

Function and regulation of the transcription factors of the Myc/Max/Mad network

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

c-Myc Augments Gamma Irradiation-Induced Apoptosis by Suppressing Bcl-XL

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

Akt is a downstream target of NF-kappa B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

The Oscar-worthy role of Myc in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

The RIP kinases: crucial integrators of cellular stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

c-Myc primed mitochondria determine cellular sensitivity to TRAIL-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

c-Myc blazing a trail of death: coupling of the mitochondrial and death receptor apoptosis pathways by c-Myc

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

Tumor cell-selective regulation of NOXA by c-MYC in response to proteasome inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

Myc pathways provoking cell suicide and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

The myc oncogene: MarvelouslY Complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

Functional analysis of the N-terminal domain of the Myc oncoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

Targeting of Miz-1 is essential for Myc-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

BCL2 is a downstream effector of MIZ-1 essential for blocking c-MYC-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

ARF and ATM/ATR cooperate in p53-mediated apoptosis upon oncogenic stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

ATM promotes apoptosis and suppresses tumorigenesis in response to Myc.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

Direct repression of FLIP expression by c-myc is a major determinant of TRAIL sensitivity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

Reduction of TRAIL-induced Mcl-1 and cIAP2 by c-Myc or sorafenib sensitizes resistant human cancer cells to TRAIL-induced death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

Hepatocyte growth factor induces Mcl-1 in primary human hepatocytes and inhibits CD95-mediated apoptosis via Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

Phosphatidylinositol 3-kinase/Akt signaling mediates interleukin-6 protection against p53-induced apoptosis in M1 myeloid leukemic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

Switching from life to death: the Miz-ing link between Myc and p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

Synthetic lethal targeting of MYC by activation of the DR5 death receptor pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

Myc suppression of the p21 Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

CELL BIOLOGY: Double Knockout Blow for Caspases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

p53-independent apoptosis associated with c-Myc-mediated block in myeloid cell differentiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

p14ARF directly interacts with Myc through the Myc BoxII domain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

The antiapoptotic effect of IL-6 autocrine loop in a cellular model of advanced prostate cancer is mediated by Mcl-1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

Microarray analysis of p53-dependent gene expression in response to hypoxia and DNA damage

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

Inhibition of neutrophil apoptosis by TLR agonists in whole blood: involvement of the phosphoinositide 3-kinase/Akt and NF-kappaB signaling pathways, leading to increased levels of Mcl-1, A1, and phosphorylated Bad

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

The proto-oncogene c-myc and apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

Requirement for the CD95 receptor-ligand pathway in c-Myc-induced apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

Regulation of Myc function by ARF: checkpoint for Myc-induced oncogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.312

31 March 2020

Identifiers

DOI

10.1038/ONC.2008.312

1 reference

19 August 2017

1 reference

PubMed ID

18955973