(Q74243929)

English

c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability

scientific article published on 01 May 2002

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scholarly article

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Europe PubMed Central

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9 November 2019

c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability (English)

1 reference

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9 November 2019

reactive oxygen species

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author name string

Omid Vafa

1

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9 November 2019

Mark Wade

2

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9 November 2019

Suzanne Kern

3

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9 November 2019

Michelle Beeche

4

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9 November 2019

Tej K Pandita

5

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9 November 2019

Garret M Hampton

6

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9 November 2019

Geoffrey M Wahl

7

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9 November 2019

publication date

1 May 2002

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9 November 2019

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9 November 2019

9

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9 November 2019

1031-1044

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9 November 2019

5

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9 November 2019

p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts

1 reference

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7 January 2021

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A p53-dependent S-phase checkpoint helps to protect cells from DNA damage in response to starvation for pyrimidine nucleotides

1 reference

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7 January 2021

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Cyclin E and c-Myc promote cell proliferation in the presence of p16INK4a and of hypophosphorylated retinoblastoma family proteins.

1 reference

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7 January 2021

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Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

1 reference

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7 January 2021

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p14ARF links the tumour suppressors RB and p53.

1 reference

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7 January 2021

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Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome

1 reference

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7 January 2021

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Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900520-8

7 January 2021

based on heuristic

inferred from DOI database lookup

c-Myc target genes involved in cell growth, apoptosis, and metabolism

1 reference

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7 January 2021

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The human Ha-ras oncogene induces genomic instability in murine fibroblasts within one cell cycle

1 reference

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7 January 2021

based on heuristic

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DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900520-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Primary cells suppress oncogene-dependent apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900520-8

7 January 2021

based on heuristic

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Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900520-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Cluster analysis and display of genome-wide expression patterns

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Definition of a consensus binding site for p53

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900520-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Induction of apoptosis in fibroblasts by c-myc protein

1 reference

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7 January 2021

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Disruption of redox homeostasis in the transforming growth factor-alpha/c-myc transgenic mouse model of accelerated hepatocarcinogenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900520-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Transient excess of MYC activity can elicit genomic instability and tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900520-8

7 January 2021

based on heuristic

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The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900520-8

7 January 2021

based on heuristic

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Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900520-8

7 January 2021

based on heuristic

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Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900520-8

7 January 2021

based on heuristic

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Genetic background alters the spectrum of tumors that develop in p53-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900520-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Mediation of c-Myc-induced apoptosis by p53.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900520-8

7 January 2021

based on heuristic

inferred from DOI database lookup

14-3-3sigma is a p53-regulated inhibitor of G2/M progression

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900520-8

7 January 2021

based on heuristic

inferred from DOI database lookup

p53 mutations in human cancers

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900520-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Expression of the p48 xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repair

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900520-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900520-8

7 January 2021

based on heuristic

inferred from DOI database lookup

A transactivation-deficient mouse model provides insights into Trp53 regulation and function

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900520-8

7 January 2021

based on heuristic

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Mammalian Cell Fusion : Induction of Premature Chromosome Condensation in Interphase Nuclei

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900520-8

7 January 2021

based on heuristic

inferred from DOI database lookup

c-Myc-induced sensitization to apoptosis is mediated through cytochrome c release

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900520-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900520-8

7 January 2021

based on heuristic

inferred from DOI database lookup

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900520-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of p53 as a sequence-specific DNA-binding protein

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900520-8

7 January 2021

based on heuristic

inferred from DOI database lookup

p53: puzzle and paradigm

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900520-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900520-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900520-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Myc represses transcription of the growth arrest gene gas1

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900520-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of topoisomerase II-mediated excision of chromosomal DNA loops during oxidative stress.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900520-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Endonuclease G is an apoptotic DNase when released from mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900520-8

7 January 2021

based on heuristic

inferred from DOI database lookup

A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900520-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900520-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Genomic instability in MycER-activated Rat1A-MycER cells

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900520-8

7 January 2021

based on heuristic

inferred from DOI database lookup

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

1 reference

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7 January 2021

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Inhibition of Ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the Bcl-2 homologue Bak

1 reference

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7 January 2021

based on heuristic

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Selective modification of glutathione metabolism

1 reference

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7 January 2021

based on heuristic

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In situ visualization of DNA double-strand break repair in human fibroblasts

1 reference

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7 January 2021

based on heuristic

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The clonal evolution of tumor cell populations

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Gene-target recognition among members of the myc superfamily and implications for oncogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900520-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Production of hydrogen peroxide by transforming growth factor-beta 1 and its involvement in induction of egr-1 in mouse osteoblastic cells

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900520-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Ornithine decarboxylase is a mediator of c-Myc-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900520-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Effect of chromosome size on aberration levels caused by gamma radiation as detected by fluorescence in situ hybridization

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900520-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Gene amplification in a p53-deficient cell line requires cell cycle progression under conditions that generate DNA breakage

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900520-8

7 January 2021

based on heuristic

inferred from DOI database lookup

A model for p53-induced apoptosis

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Inefficient growth arrest in response to dNTP starvation stimulates gene amplification through bridge-breakage-fusion cycles

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900520-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900520-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900520-8

7 January 2021

based on heuristic

inferred from DOI database lookup

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

ATM: a mediator of multiple responses to genotoxic stress

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

A subset of p53-deficient embryos exhibit exencephaly

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900520-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Overexpression of c-Myc alters G(1)/S arrest following ionizing radiation

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900520-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Tumor surveillance via the ARF-p53 pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900520-8

7 January 2021

based on heuristic

inferred from DOI database lookup

The ARF/p53 pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900520-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900520-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Human CENP-A contains a histone H3 related histone fold domain that is required for targeting to the centromere

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Transgenic mouse models in carcinogenesis research and testing

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The evolution of diverse biological responses to DNA damage: insights from yeast and p53.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900520-8

7 January 2021

based on heuristic

inferred from DOI database lookup

The yield of DNA double-strand breaks produced intracellularly by ionizing radiation: a review

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Analysis of gene expression profiles in normal and neoplastic ovarian tissue samples identifies candidate molecular markers of epithelial ovarian cancer

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Genome-wide expression monitoring in Saccharomyces cerevisiae

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900520-8

7 January 2021

based on heuristic

inferred from DOI database lookup

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900520-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900520-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S1097-2765(02)00520-8

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9 November 2019

1 reference

Europe PubMed Central

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9 November 2019

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