(Q39793002)

14 September 2017

title

PKC-alpha inhibitor MT477 slows tumor growth with minimal toxicity in in vivo model of non-Ras-mutated cancer via induction of apoptosis (English)

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14 September 2017

Piotr Jasinski

1

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14 September 2017

Pawel Zwolak

2

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14 September 2017

Kaoru Terai

3

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14 September 2017

Daniel Borja-Cacho

4

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14 September 2017

Arkadiusz Z Dudek

5

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14 September 2017

publication date

1 October 2009

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Investigational New Drugs

14 September 2017

published in

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14 September 2017

volume

29

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14 September 2017

issue

1

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14 September 2017

page(s)

33-40

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https://scigraph.springernature.com/pub.10.1007/s10637-009-9330-9

14 September 2017

exact match

0 references

cites work

The extended protein kinase C superfamily

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS10637-009-9330-9

Protein kinase C-alpha overexpression stimulates Akt activity and suppresses apoptosis induced by interleukin 3 withdrawal

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1 reference

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Enzastaurin renders MCF-7 breast cancer cells sensitive to radiation through reversal of radiation-induced activation of protein kinase C.

1 reference

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Suppression of lung cancer tumor growth in a nude mouse model by the Ras inhibitor salirasib (farnesylthiosalicylic acid).

1 reference

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A Ras inhibitor tilts the balance between Rac and Rho and blocks phosphatidylinositol 3-kinase-dependent glioblastoma cell migration

1 reference

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Protein kinase C: a target for anticancer drugs?

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12 December 2020

Protein kinase C activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf.

1 reference

12 December 2020

Protein kinase C alpha activates RAF-1 by direct phosphorylation

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12 December 2020

Topological approach to drug design

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12 December 2020

Reorganization of actin cytoskeleton by the phosphoinositide metabolite glycerophosphoinositol 4-phosphate

1 reference

12 December 2020

Protein kinase C-alpha: a novel target for the therapy of androgen-independent prostate cancer? (Review-hypothesis)

1 reference

12 December 2020

A novel quinoline, MT477: suppresses cell signaling through Ras molecular pathway, inhibits PKC activity, and demonstrates in vivo anti-tumor activity against human carcinoma cell lines

1 reference

12 December 2020

Antiangiogenic and antitumor effects of a protein kinase Cbeta inhibitor in human breast cancer and ovarian cancer xenografts

1 reference

12 December 2020

Toll-like receptor 3 triggers apoptosis of human prostate cancer cells through a PKC-alpha-dependent mechanism.

1 reference

12 December 2020

Regulation of protein kinase B/Akt activity and Ser473 phosphorylation by protein kinase Calpha in endothelial cells

1 reference

12 December 2020

Protein kinase C alpha expression in breast and ovarian cancer

1 reference

12 December 2020

Estrogen and resveratrol regulate Rac and Cdc42 signaling to the actin cytoskeleton of metastatic breast cancer cells

1 reference

12 December 2020

The Rho kinase inhibitor fasudil inhibits tumor progression in human and rat tumor models

1 reference

12 December 2020

Signaling cascades in radiation-induced apoptosis: roles of protein kinase C in the apoptosis regulation.

1 reference

12 December 2020

Novel Ras pathway inhibitor induces apoptosis and growth inhibition of K-ras-mutated cancer cells in vitro and in vivo

1 reference

12 December 2020

Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS.

1 reference

12 December 2020

Effects of regulatory domains of specific isoforms of protein kinase C on growth control and apoptosis in MCF-7 breast cancer cells

1 reference

12 December 2020

Effect of protein kinase C alpha, caspase-3, and survivin on apoptosis of oral cancer cells induced by staurosporine

1 reference

12 December 2020

Bisubstrate inhibitors of farnesyltransferase: a novel class of specific inhibitors of ras transformed cells.

1 reference

12 December 2020

Growth inhibition of ras-dependent tumors in nude mice by a potent ras-dislodging antagonist

1 reference

12 December 2020

10.1007/S10637-009-9330-9

Identifiers

DOI

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14 September 2017

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