(Q40063308)

English

A novel quinoline, MT477: suppresses cell signaling through Ras molecular pathway, inhibits PKC activity, and demonstrates in vivo anti-tumor activity against human carcinoma cell lines

scientific article published on 24 October 2007

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scholarly article

1 reference

Europe PubMed Central

17 September 2017

A novel quinoline, MT477: suppresses cell signaling through Ras molecular pathway, inhibits PKC activity, and demonstrates in vivo anti-tumor activity against human carcinoma cell lines (English)

1 reference

Europe PubMed Central

17 September 2017

author name string

Piotr Jasinski

1

1 reference

Europe PubMed Central

17 September 2017

Brandon Welsh

2

1 reference

Europe PubMed Central

17 September 2017

Jorge Galvez

3

1 reference

Europe PubMed Central

17 September 2017

David Land

4

1 reference

Europe PubMed Central

17 September 2017

Pawel Zwolak

5

1 reference

Europe PubMed Central

17 September 2017

Lori Ghandi

6

1 reference

Europe PubMed Central

17 September 2017

Kaoru Terai

7

1 reference

Europe PubMed Central

17 September 2017

Arkadiusz Z Dudek

8

1 reference

Europe PubMed Central

17 September 2017

publication date

24 October 2007

1 reference

Europe PubMed Central

17 September 2017

Investigational New Drugs

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Europe PubMed Central

17 September 2017

26

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Europe PubMed Central

17 September 2017

3

1 reference

Europe PubMed Central

17 September 2017

223-232

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Europe PubMed Central

17 September 2017

https://scigraph.springernature.com/pub.10.1007/s10637-007-9096-x

0 references

K-ras gene mutation enhances motility of immortalized airway cells and lung adenocarcinoma cells via Akt activation: possible contribution to non-invasive expansion of lung adenocarcinoma.

1 reference

https://api.crossref.org/works/10.1007%2FS10637-007-9096-X

21 January 2018

Fra-1 induces morphological transformation and increases in vitro invasiveness and motility of epithelioid adenocarcinoma cells

1 reference

https://api.crossref.org/works/10.1007%2FS10637-007-9096-X

21 January 2018

Cell death: the significance of apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17957339

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C lies on the signaling pathway for vascular endothelial growth factor-mediated tumor development and angiogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17957339

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel target cell for c-fos-induced oncogenesis: development of chondrogenic tumours in embryonic stem cell chimeras

1 reference

https://pubmed.ncbi.nlm.nih.gov/17957339

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SIGNAL TRANSDUCTION: Prelude to an Anniversary for the RAS Oncogene

1 reference

https://pubmed.ncbi.nlm.nih.gov/17957339

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of c-fos expression in benign and malignant musculoskeletal lesions

1 reference

https://pubmed.ncbi.nlm.nih.gov/17957339

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of DNA strand breaks associated with apoptosis during treatment of leukemias.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17957339

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C alpha activates RAF-1 by direct phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17957339

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radioresistance of K-Ras mutated human tumor cells is mediated through EGFR-dependent activation of PI3K-AKT pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/17957339

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signal transduction through MAP kinase cascades

1 reference

https://pubmed.ncbi.nlm.nih.gov/17957339

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Topological approach to drug design

1 reference

https://pubmed.ncbi.nlm.nih.gov/17957339

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of ERK during DNA damage-induced apoptosis involves protein kinase Cdelta

1 reference

https://pubmed.ncbi.nlm.nih.gov/17957339

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Central role of protein kinase Cepsilon in constitutive activation of ERK1/2 and Rac1 in the malignant cells of hairy cell leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17957339

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Somatic activation of the K-ras oncogene causes early onset lung cancer in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17957339

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FGF-2 and TPA induce matrix metalloproteinase-9 secretion in MCF-7 cells through PKC activation of the Ras/ERK pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/17957339

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arsenic trioxide triggers a regulated form of caspase-independent necrotic cell death via the mitochondrial death pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/17957339

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C (PKC) betaII induces cell invasion through a Ras/Mek-, PKC iota/Rac 1-dependent signaling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/17957339

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Understanding Ras: 'it ain't over 'til it's over'.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17957339

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of the ERK signaling cascade in protein kinase C-mediated cell cycle arrest in intestinal epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17957339

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential signalling of purinoceptors in HeLa cells through the extracellular signal-regulated kinase and protein kinase C pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/17957339

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An essential role for Rac in Ras transformation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17957339

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C inhibitors as novel anticancer drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/17957339

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of markers of normal differentiation in human colon carcinoma cells by the v-rasH oncogene.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17957339

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of glucose-regulated protein 78 by chronic hypoxia in human gastric tumor cells through a protein kinase C-epsilon/ERK/AP-1 signaling cascade

1 reference

https://pubmed.ncbi.nlm.nih.gov/17957339

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C alpha expression in breast and ovarian cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/17957339

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting RAS signalling pathways in cancer therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/17957339

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Atypical protein kinase C iota is an oncogene in human non-small cell lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/17957339

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of a Protein Kinase that Phosphorylates Serine 189 of the Mitogen-activated Protein Kinase Homolog ERK3

1 reference

https://pubmed.ncbi.nlm.nih.gov/17957339

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of extracellular signal-regulated kinases (ERKs) defines the first phase of 1,25-dihydroxyvitamin D3-induced differentiation of HL60 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17957339

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential regulation of glycogen synthase kinase-3 beta by protein kinase C isotypes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17957339

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calmodulin prevents activation of Ras by PKC in 3T3 fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/17957339

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting protein kinase C: new therapeutic opportunities against high-grade malignant gliomas?

1 reference

https://pubmed.ncbi.nlm.nih.gov/17957339

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of gene expression profiles that predict the aggressive behavior of breast cancer cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17957339

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of PKC-beta or cyclin D2 predicts for inferior survival in diffuse large B-cell lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/17957339

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase Calpha and protein kinase Cdelta play opposite roles in the proliferation and apoptosis of glioma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17957339

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/17957339

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cell cycle related differences in susceptibility of HL-60 cells to apoptosis induced by various antitumor agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/17957339

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated protein kinase C betaII is an early promotive event in colon carcinogenesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17957339

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C-beta inhibitor enzastaurin (LY317615.HCI) enhances radiation control of murine breast cancer in an orthotopic model of bone metastasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17957339

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S10637-007-9096-X

1 reference

Europe PubMed Central

17 September 2017

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0 references

1 reference

Europe PubMed Central

17 September 2017

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