(Q40084195)

English

Protein kinase C-beta inhibitor enzastaurin (LY317615.HCI) enhances radiation control of murine breast cancer in an orthotopic model of bone metastasis

scientific article published on 6 September 2007

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

Protein kinase C-beta inhibitor enzastaurin (LY317615.HCI) enhances radiation control of murine breast cancer in an orthotopic model of bone metastasis (English)

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

Faris Farassati

7

object named as

Faris Farassati

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

author name string

Arkadiusz Z Dudek

1

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

Pawel Zwolak

2

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

Piotr Jasinski

3

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

Kaoru Terai

4

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

Nathan J Gallus

5

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

Marna E Ericson

6

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

publication date

6 September 2007

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

Investigational New Drugs

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

26

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

13-24

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

https://scigraph.springernature.com/pub.10.1007/s10637-007-9079-y

0 references

The extended protein kinase C superfamily

1 reference

https://api.crossref.org/works/10.1007%2FS10637-007-9079-Y

21 January 2018

LY317615 decreases plasma VEGF levels in human tumor xenograft-bearing mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17805485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Simultaneous reduction in cancer pain, bone destruction, and tumor growth by selective inhibition of cyclooxygenase-2

1 reference

https://pubmed.ncbi.nlm.nih.gov/17805485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Origins of skeletal pain: sensory and sympathetic innervation of the mouse femur

1 reference

https://pubmed.ncbi.nlm.nih.gov/17805485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Advances in understanding bone cancer pain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17805485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Osteoprotegerin blocks bone cancer-induced skeletal destruction, skeletal pain and pain-related neurochemical reorganization of the spinal cord

1 reference

https://pubmed.ncbi.nlm.nih.gov/17805485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C alpha activates RAF-1 by direct phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17805485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I pharmacokinetic and pharmacodynamic study of the oral protein kinase C beta-inhibitor enzastaurin in combination with gemcitabine and cisplatin in patients with advanced cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/17805485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of angiogenesis-related genes and progression of human ovarian carcinomas in nude mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17805485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-NGF therapy profoundly reduces bone cancer pain and the accompanying increase in markers of peripheral and central sensitization

1 reference

https://pubmed.ncbi.nlm.nih.gov/17805485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A general strategy for isolation of endothelial cells from murine tissues. Characterization of two endothelial cell lines from the murine lung and subcutaneous sponge implants

1 reference

https://pubmed.ncbi.nlm.nih.gov/17805485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts

1 reference

https://pubmed.ncbi.nlm.nih.gov/17805485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The selective protein kinase C beta inhibitor enzastaurin induces apoptosis in cutaneous T-cell lymphoma cell lines through the AKT pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/17805485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation and transplantation of allogeneic pulmonary endothelium derived from GFP transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17805485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C betaII regulates Akt phosphorylation on Ser-473 in a cell type- and stimulus-specific fashion.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17805485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FGF-2 and TPA induce matrix metalloproteinase-9 secretion in MCF-7 cells through PKC activation of the Ras/ERK pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/17805485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C (PKC) betaII induces cell invasion through a Ras/Mek-, PKC iota/Rac 1-dependent signaling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/17805485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C-mediated regulation of the cell cycle

1 reference

https://pubmed.ncbi.nlm.nih.gov/17805485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Participation of protein kinase C beta in osteoclast differentiation and function

1 reference

https://pubmed.ncbi.nlm.nih.gov/17805485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C alpha expression in breast and ovarian cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/17805485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium-sensing receptor stimulates PTHrP release by pathways dependent on PKC, p38 MAPK, JNK, and ERK1/2 in H-500 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17805485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The parathyroid hormone-related protein receptor is expressed in breast cancer bone metastases and promotes autocrine proliferation in breast carcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17805485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enzastaurin (LY317615), a protein kinase Cbeta inhibitor, inhibits the AKT pathway and induces apoptosis in multiple myeloma cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/17805485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synergistic antiglioma activity of radiotherapy and enzastaurin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17805485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective inhibition of Ras, phosphoinositide 3 kinase, and Akt isoforms increases the radiosensitivity of human carcinoma cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/17805485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Osteoclastic acidification pathways during bone resorption

1 reference

https://pubmed.ncbi.nlm.nih.gov/17805485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An acid sensing ion channel (ASIC) localizes to small primary afferent neurons in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/17805485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I dose escalation and pharmacokinetic study of enzastaurin, an oral protein kinase C beta inhibitor, in patients with advanced cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/17805485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential regulation of glycogen synthase kinase-3 beta by protein kinase C isotypes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17805485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Macrophage colony stimulating factor increases bone resorption in dispersed osteoclast cultures by increasing osteoclast size

1 reference

https://pubmed.ncbi.nlm.nih.gov/17805485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radiation treatment decreases bone cancer pain, osteolysis and tumor size.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17805485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of the calcium receptor in human breast cancer--a potential new marker predicting the risk of bone metastases

1 reference

https://pubmed.ncbi.nlm.nih.gov/17805485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blockade of epidermal growth factor receptor signaling leads to inhibition of renal cell carcinoma growth in the bone of nude mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17805485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Conserved RAS/Mitogen-Activated Protein Kinase Pathway Regulates DNA Damage–Induced Cell Death Postirradiation in Radelegans

1 reference

https://pubmed.ncbi.nlm.nih.gov/17805485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S10637-007-9079-Y

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

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