(Q39802734)

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Impaired recruitment of the histone methyltransferase DOT1L contributes to the incomplete reactivation of tumor suppressor genes upon DNA demethylation

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scholarly article

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Europe PubMed Central

14 September 2017

Impaired recruitment of the histone methyltransferase DOT1L contributes to the incomplete reactivation of tumor suppressor genes upon DNA demethylation (English)

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Europe PubMed Central

14 September 2017

3

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Europe PubMed Central

14 September 2017

Esteban Ballestar

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E Ballestar

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F V Jacinto

1

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Europe PubMed Central

14 September 2017

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publication date

7 September 2009

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Europe PubMed Central

14 September 2017

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Europe PubMed Central

14 September 2017

28

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Europe PubMed Central

14 September 2017

47

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Europe PubMed Central

14 September 2017

4212-4224

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Europe PubMed Central

14 September 2017

https://scigraph.springernature.com/pub.10.1038/onc.2009.267

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Roles of the EZH2 histone methyltransferase in cancer epigenetics

1 reference

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GATA-4 and GATA-5 transcription factor genes and potential downstream antitumor target genes are epigenetically silenced in colorectal and gastric cancer

1 reference

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Methyl-CpG binding proteins identify novel sites of epigenetic inactivation in human cancer.

1 reference

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The complex language of chromatin regulation during transcription

1 reference

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Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

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Aberrant CpG-island methylation has non-random and tumour-type-specific patterns.

1 reference

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Epigenetics in cancer

1 reference

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Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain

1 reference

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Demethylating agents in myeloid malignancies

1 reference

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The epigenomics of cancer

1 reference

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Critical role of histone methylation in tumor suppressor gene silencing in colorectal cancer.

1 reference

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Chromatin modifications and their function

1 reference

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Proteins that bind methylated DNA and human cancer: reading the wrong words

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Silenced tumor suppressor genes reactivated by DNA demethylation do not return to a fully euchromatic chromatin state

1 reference

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Leukemogenic MLL fusion proteins bind across a broad region of the Hox a9 locus, promoting transcription and multiple histone modifications

1 reference

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Structure of the catalytic domain of human DOT1L, a non-SET domain nucleosomal histone methyltransferase

1 reference

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Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association

1 reference

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hDOT1L links histone methylation to leukemogenesis

1 reference

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Decitabine--bedside to bench

1 reference

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DNMT1 and DNMT3b cooperate to silence genes in human cancer cells

1 reference

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A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer

1 reference

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Cellular memory and the histone code

1 reference

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Dot1p modulates silencing in yeast by methylation of the nucleosome core

1 reference

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Combinatorial patterns of histone acetylations and methylations in the human genome

1 reference

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WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development

1 reference

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Epigenetic therapy of cancer: past, present and future

1 reference

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31 March 2020

Identifiers

10.1038/ONC.2009.267

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Europe PubMed Central

14 September 2017

1 reference

Europe PubMed Central

14 September 2017

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