(Q39802948)

English

Liver Glucokinase(A456V) Induces Potent Hypoglycemia without Dyslipidemia through a Paradoxical Induction of the Catalytic Subunit of Glucose-6-Phosphatase

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scholarly article

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Europe PubMed Central

PMC publication ID

14 September 2017

Liver Glucokinase(A456V) Induces Potent Hypoglycemia without Dyslipidemia through a Paradoxical Induction of the Catalytic Subunit of Glucose-6-Phosphatase (English)

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

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1 reference

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inferred from title

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inferred from title

Anna Vidal-Alabró

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5

object named as

Ramon Bartrons

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

author name string

Anna Vidal-Alabró

1

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Alícia G Gómez-Valadés

2

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Andrés Méndez-Lucas

3

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Jordi Llorens

4

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Jordi Bermúdez

6

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Jose C Perales

7

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

publication date

13 December 2011

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

International journal of endocrinology

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

2011

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

707928

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

copyright license

Creative Commons Attribution 3.0 Unported

1 January 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

1 reference

April 2022 Public Data File from Crossref

Assessing the potential of glucokinase activators in diabetes therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3238378

22 September 2017

The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3238378

22 September 2017

The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3238378

22 September 2017

Biochemical basis of glucokinase activation and the regulation by glucokinase regulatory protein in naturally occurring mutations

1 reference

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22 September 2017

An allosteric activator of glucokinase impairs the interaction of glucokinase and glucokinase regulatory protein and regulates glucose metabolism

1 reference

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22 September 2017

Phosphoenolpyruvate carboxykinase and the critical role of cataplerosis in the control of hepatic metabolism

1 reference

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22 September 2017

Overcoming diabetes-induced hyperglycemia through inhibition of hepatic phosphoenolpyruvate carboxykinase (GTP) with RNAi.

1 reference

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22 September 2017

Small molecule glucokinase activators as novel anti-diabetic agents.

1 reference

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22 September 2017

Gene therapy for type 1 diabetes. New approaches.

1 reference

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22 September 2017

Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3238378

22 September 2017

Evidence that glucokinase regulatory protein is expressed and interacts with glucokinase in rat brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3238378

22 September 2017

Glucose sensing in pancreatic beta-cells: a model for the study of other glucose-regulated cells in gut, pancreas, and hypothalamus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3238378

22 September 2017

Overexpression of 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase in mouse liver lowers blood glucose by suppressing hepatic glucose production

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3238378

22 September 2017

Characterization of glucokinase regulatory protein-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3238378

22 September 2017

New lessons in the regulation of glucose metabolism taught by the glucose 6-phosphatase system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3238378

22 September 2017

Mice mutant for glucokinase regulatory protein exhibit decreased liver glucokinase: a sequestration mechanism in metabolic regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3238378

22 September 2017

Perturbation of fuel homeostasis caused by overexpression of the glucose-6-phosphatase catalytic subunit in liver of normal rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3238378

22 September 2017

Correction of diabetic alterations by glucokinase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3238378

22 September 2017

Analysis of upstream glucokinase promoter activity in transgenic mice and identification of glucokinase in rare neuroendocrine cells in the brain and gut.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3238378

22 September 2017

Efficient selection for high-expression transfectants with a novel eukaryotic vector

1 reference

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22 September 2017

The regulatory protein of liver glucokinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3238378

22 September 2017

Thiamine pyrophosphate-requiring enzymes are altered during pyrithiamine-induced thiamine deficiency in cultured human lymphoblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3238378

25 September 2017

The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3238378

15 June 2018

Glucokinase thermolability and hepatic regulatory protein binding are essential factors for predicting the blood glucose phenotype of missense mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3238378

15 June 2018

Silencing of episomal transgene expression by plasmid bacterial DNA elements in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3238378

15 June 2018

Glucokinase and glucokinase regulatory protein: mutual dependence for nuclear localization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3238378

15 June 2018

Arterial oxygen partial pressures reduce the insulin-dependent induction of the perivenously located glucokinase in rat hepatocyte cultures: mimicry of arterial oxygen pressures by H2O2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3238378

15 June 2018

Factors underlying significant underestimations of glucokinase activity in crude liver extracts: physiological implications of higher cellular activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3238378

15 June 2018

Glucokinase activation induces potent hypoglycemia without recruiting insulin and inhibits food intake in chicken

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3238378

20 August 2018

A glucose sensor role for glucokinase in anterior pituitary cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3238378

20 August 2018

A novel glucokinase activator modulates pancreatic islet and hepatocyte function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3238378

20 August 2018

Insulin-independent induction of sterol regulatory element-binding protein-1c expression in the livers of streptozotocin-treated mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3238378

20 August 2018

Stimulation of hepatocyte glucose metabolism by novel small molecule glucokinase activators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3238378

20 August 2018

A modest glucokinase overexpression in the liver promotes fed expression levels of glycolytic and lipogenic enzyme genes in the fasted state without altering SREBP-1c expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3238378

20 August 2018

Long-term overexpression of glucokinase in the liver of transgenic mice leads to insulin resistance.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3238378

20 August 2018

Allosteric activators of glucokinase: potential role in diabetes therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3238378

20 August 2018

Adenovirus-mediated expression of glucokinase in the liver as an adjuvant treatment for type 1 diabetes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3238378

20 August 2018

Linear DNAs concatemerize in vivo and result in sustained transgene expression in mouse liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3238378

20 August 2018

Overexpression of the P46 (T1) translocase component of the glucose-6-phosphatase complex in hepatocytes impairs glycogen accumulation via hydrolysis of glucose 1-phosphate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3238378

20 August 2018

Regulation of the glucose-6-phosphatase gene by glucose occurs by transcriptional and post-transcriptional mechanisms. Differential effect of glucose and xylitol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3238378

20 August 2018

Metabolic impact of glucokinase overexpression in liver: lowering of blood glucose in fed rats is accompanied by hyperlipidemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3238378

20 August 2018

Genetic heterogeneity in response to adenovirus gene therapy

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https://api.crossref.org/works/10.1155%2F2011%2F707928

21 January 2018

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1 reference

https://pubmed.ncbi.nlm.nih.gov/22194744

12 December 2020

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Carbon flux via the pentose phosphate pathway regulates the hepatic expression of the glucose-6-phosphatase and phosphoenolpyruvate carboxykinase genes in conscious rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/22194744

12 December 2020

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Effects of glucose metabolism on the regulation of genes of fatty acid synthesis and triglyceride secretion in the liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/22194744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose-6-phosphatase overexpression lowers glucose 6-phosphate and inhibits glycogen synthesis and glycolysis in hepatocytes without affecting glucokinase translocation. Evidence against feedback inhibition of glucokinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/22194744

12 December 2020

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Metabolic Impact of Adenovirus-mediated Overexpression of the Glucose-6-phosphatase Catalytic Subunit in Hepatocytes

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https://pubmed.ncbi.nlm.nih.gov/22194744

12 December 2020

based on heuristic

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1 reference

https://pubmed.ncbi.nlm.nih.gov/22194744

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A kinetic study of pyrophosphate: fructose-6-phosphate phosphotransferase from potato tubers. Application to a microassay of fructose 2,6-bisphosphate

1 reference

https://pubmed.ncbi.nlm.nih.gov/22194744

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Identifiers

10.1155/2011/707928

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

ResearchGate publication ID

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