(Q39806420)

14 September 2017

The deubiquitinase A20 mediates feedback inhibition of interleukin-17 receptor signaling (English)

1 reference

14 September 2017

0 references

Abhishek V Garg

1

1 reference

14 September 2017

Mushtaq Ahmed

2

1 reference

14 September 2017

Abbe N Vallejo

3

1 reference

14 September 2017

Averil Ma

4

1 reference

14 September 2017

Sarah L Gaffen

5

1 reference

14 September 2017

language of work or name

1 reference

4 June 2013

1 reference

14 September 2017

1 reference

14 September 2017

6

1 reference

14 September 2017

278

1 reference

14 September 2017

ra44

1 reference

describes a project that uses

14 September 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4028484/fullTextXML

inferred from PubMed Central ID database lookup

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Deubiquitinases regulate the activity of caspase-1 and interleukin-1β secretion via assembly of the inflammasome

22 September 2017

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A20: linking a complex regulator of ubiquitylation to immunity and human disease

22 September 2017

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Negative regulation of IL-17-mediated signaling and inflammation by the ubiquitin-specific protease USP25

22 September 2017

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22 September 2017

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22 September 2017

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22 September 2017

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22 September 2017

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22 September 2017

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22 September 2017

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Persistent stimulation with interleukin-17 desensitizes cells through SCFβ-TrCP-mediated degradation of Act1.

22 September 2017

1 reference

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Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis.

22 September 2017

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Recent advances in the IL-17 cytokine family

22 September 2017

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Return to homeostasis: downregulation of NF-κB responses

22 September 2017

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IL-17 receptor signaling and T helper 17-mediated autoimmune demyelinating disease

22 September 2017

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Functional specialization of interleukin-17 family members

22 September 2017

1 reference

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IL-17-induced NF-kappaB activation via CIKS/Act1: physiologic significance and signaling mechanisms

22 September 2017

1 reference

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Fate mapping of IL-17-producing T cells in inflammatory responses

22 September 2017

1 reference

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Ubiquitin makes its mark on immune regulation

22 September 2017

1 reference

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Ubiquitin binding to A20 ZnF4 is required for modulation of NF-κB signaling

22 September 2017

1 reference

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Modulation of experimental autoimmune encephalomyelitis through TRAF3-mediated suppression of interleukin 17 receptor signaling

22 September 2017

1 reference

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IL-17 family member cytokines: regulation and function in innate immunity.

22 September 2017

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Effects of AIN457, a Fully Human Antibody to Interleukin-17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis

22 September 2017

1 reference

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SEF/IL-17R (SEFIR) is not enough: an extended SEFIR domain is required for il-17RA-mediated signal transduction

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028484

Inborn errors of mucocutaneous immunity to Candida albicans in humans: a role for IL-17 cytokines?

22 September 2017

1 reference

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Expression, biological activities and mechanisms of action of A20 (TNFAIP3).

22 September 2017

1 reference

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Innate IL-17-producing cells: the sentinels of the immune system

22 September 2017

1 reference

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IL-17RC is required for immune signaling via an extended SEF/IL-17R signaling domain in the cytoplasmic tail

22 September 2017

1 reference

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Toll-like receptor signaling: a potential link among rheumatoid arthritis, systemic lupus, and atherosclerosis

22 September 2017

1 reference

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Diversity in post-transcriptional control of neutrophil chemoattractant cytokine gene expression

22 September 2017

1 reference

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Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease

22 September 2017

1 reference

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Unraveling the genetics of autoimmunity

22 September 2017

1 reference

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Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes

22 September 2017

1 reference

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LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I randomized, double-blind, placebo-controlled, proof-of-concept study

22 September 2017

1 reference

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IL-17 regulates CXCL1 mRNA stability via an AUUUA/tristetraprolin-independent sequence

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028484

Act1, a U-box E3 ubiquitin ligase for IL-17 signaling.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028484

The functional plasticity of T cell subsets

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028484

The role of interleukin-17 in the pathogenesis of rheumatoid arthritis

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028484

Structure and signalling in the IL-17 receptor family

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028484

Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028484

TNFalpha-induced macrophage death via caspase-dependent and independent pathways

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028484

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028484

Cytokines that regulate autoimmunity

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028484

The human IL-17F/IL-17A heterodimeric cytokine signals through the IL-17RA/IL-17RC receptor complex

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028484

Molecular antagonism and plasticity of regulatory and inflammatory T cell programs

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028484

Deubiquitylation and regulation of the immune response

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028484

Advances in understanding the anti-inflammatory properties of IL-27.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028484

The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028484

Negative regulation of Th17 responses

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028484

Structure-function relationships in the IL-17 receptor: implications for signal transduction and therapy

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028484

Act1 modulates autoimmunity through its dual functions in CD40L/BAFF and IL-17 signaling

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028484

A role for the cytoplasmic adaptor protein Act1 in mediating IL-17 signaling.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028484

Cytokines in the pathogenesis of rheumatoid arthritis

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028484

Distinct functional motifs within the IL-17 receptor regulate signal transduction and target gene expression

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028484

Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028484

IL-17 family cytokines and the expanding diversity of effector T cell lineages

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028484

IL-25 regulates Th17 function in autoimmune inflammation

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028484

A genome-wide association study identifies IL23R as an inflammatory bowel disease gene

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028484

Identification of common transcriptional regulatory elements in interleukin-17 target genes

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028484

Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028484

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028484

Cytokines link osteoblasts and inflammation: microarray analysis of interleukin-17- and TNF-alpha-induced genes in bone cells

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028484

The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028484

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028484

Functional Cooperation between Interleukin-17 and Tumor Necrosis Factor-α Is Mediated by CCAAT/Enhancer-binding Protein Family Members

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028484

The STIR-domain superfamily in signal transduction, development and immunity

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028484

Interleukin-17 in rheumatoid arthritis: if T cells were to contribute to inflammation and destruction through synergy

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028484

Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappaB activation and protein-protein interactions

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028484

Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028484

CIKS, a connection to Ikappa B kinase and stress-activated protein kinase

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028484

Requirement of tumor necrosis factor receptor-associated factor (TRAF)6 in interleukin 17 signal transduction

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028484

The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028484

Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028484

The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028484

Transcriptional activation of the tumor necrosis factor alpha-inducible zinc finger protein, A20, is mediated by kappa B elements

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028484

IL-17 receptor signaling inhibits C/EBPbeta by sequential phosphorylation of the regulatory 2 domain

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028484

Identification of an interleukin 17F/17A heterodimer in activated human CD4+ T cells

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028484

A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028484

The adaptor Act1 is required for interleukin 17-dependent signaling associated with autoimmune and inflammatory disease.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028484

Act1 adaptor protein is an immediate and essential signaling component of interleukin-17 receptor

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028484

Objective assessment of cancer genes for drug discovery

20 August 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003699

Anti–Interleukin-17 Monoclonal Antibody Ixekizumab in Chronic Plaque Psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003699

Brodalumab, an Anti–Interleukin-17–Receptor Antibody for Psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003699

Destructive role of myeloid differentiation factor 88 and protective role of TRIF in interleukin-17-dependent arthritis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003699

Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23737552

12 December 2020

inferred from PubMed ID database lookup

A novel heterodimeric cytokine consisting of IL-17 and IL-17F regulates inflammatory responses

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23737552

12 December 2020

inferred from PubMed ID database lookup

The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23737552

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1126/SCISIGNAL.2003699

1 reference

14 September 2017

1 reference

14 September 2017

PubMed publication ID

23737552

1 reference